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Joint toxic effects of triazophos and imidacloprid on zebrafish (Danio rerio)

机译：三唑磷和吡虫啉对斑马鱼的联合毒性作用

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摘要

Pesticide contamination is more often found as a mixture of different pesticides in water bodies rather than individual compounds. However, regulatory risk evaluation is mostly based on the effects of individual pesticides. In the present study, we aimed to investigate the individual and joint toxicities of triazophos (TRI) and imidacloprid (IMI) to the zebrafish (Danio rerio) using acute indices and various sublethal endpoints. Results from 96-h semi-static test indicated that the LC50 values of TRI to D. rerio at multiple life stages (embryonic, larval, juvenile and adult stages) ranged from 0.49 (0.36-0.71) to 4.99 (2.06-6.81) mg a.i. L-1, which were higher than those of IMI ranging from 26.39 (19.04-38.01) to 128.9 (68.47-173.6) mg a.i. L-1. Pesticide mixtures of TRI and IMI displayed synergistic response to zebrafish embryos. Activities of carboxylesterase (CarE) and catalase (CAT) were significantly changed in most of the individual and joint exposures of pesticides compared with the control group. The expressions of 26 genes related to oxidative stress, cellular apoptosis, immune system, hypothalamic-pituitary-thyroid and hypothalamic-pituitary-gonadal axis at the mRNA level revealed that zebrafish embryos were affected by the individual or joint pesticides, and greater changes in the expressions of six genes (Mn-sod, CXCL-CIC, Diol, Dio2, tsh and vtg1) were observed when exposed to joint pesticides compared with their individual pesticides. Taken together, the synergistic effects indicated that it was highly important to incorporate joint toxicity studies, especially at low concentrations, when assessing the risk of pesticides. (C) 2018 Elsevier Ltd. All rights reserved.
机译：农药污染更常见于水体中不同农药的混合物，而不是单个化合物。但是，监管风险评估主要基于单个农药的作用。在本研究中，我们旨在使用急性指数和各种亚致死终点研究三唑磷（TRI）和吡虫啉（IMI）对斑马鱼（Danio rerio）的个体和联合毒性。 96小时半静态测试的结果表明，在多个生命阶段（胚胎，幼虫，少年和成年阶段），TRI到D. rerio的LC50值范围为0.49（0.36-0.71）至4.99（2.06-6.81）mg i L-1高于IMI，范围从26.39（19.04-38.01）到128.9（68.47-173.6）mg a.i. L-1。 TRI和IMI的农药混合物显示出对斑马鱼胚胎的协同反应。与对照组相比，大多数个体和联合农药接触中的羧酸酯酶（CarE）和过氧化氢酶（CAT）的活性均发生了显着变化。在mRNA水平上与氧化应激，细胞凋亡，免疫系统，下丘脑-垂体-甲状腺和下丘脑-垂体-性腺轴相关的26个基因的表达表明，斑马鱼的胚胎受单个或联合农药的影响，并且其变化更大。当与联合农药接触时，观察到六个基因（Mn-sod，CXCL-CIC，Diol，Dio2，tsh和vtg1）的表达与其单个农药相比。综上所述，协同作用表明，在评估农药风险时，尤其是在低浓度时，进行联合毒性研究非常重要。 （C）2018 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental pollution》 |2018年第4期|470-481|共12页
  • 作者

    Wu Shenggan; Li Xinfang; Liu Xinju; Yang Guiling; An Xuehua; Wang Qiang; Wang Yanhua;

  • 作者单位

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

    Zhejiang Acad Agr Sci, State Key Lab Breeding Base Zhejiang Sustainable, Key Lab Pesticide Residue Detect, Minist Agr,Inst Qual & Stand Agroprod,Lab Hangzho, Hangzhou 310021, Zhejiang, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Synergistic effect; Enzyme activity; Gene expression; Aquatic ecotoxicology;

    机译：协同作用酶活性基因表达水生生态毒理学;

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