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首页> 外文期刊>Environmental Pollution >Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish
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Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish

机译：聚苯乙烯微塑料在成年斑马鱼的肠道中诱发微生物群失调和炎症

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摘要

Microplastic (MP) are environmental pollutants and have the potential to cause varying degrees of aquatic toxicity. In this study, the effects on gut microbiota of adult male zebrafish exposed for 14 days to 100 and 1000 mu g/L of two sizes of polystyrene MP were evaluated. Both 0.5 and 50 mu m-diameter spherical polystyrene MP increased the volume of mucus in the gut at a concentration of 1000 a (about 1.456 x 10(10) particles/L for 0.5 mu m and 1.456 x 10(4) particles/L for 50 mu m). At the phylum level, the abundance of Bacteroidetes and Proteobacteria decreased significantly and the abundance of Firmicutes increased significantly in the gut after 14-day exposure to 1000 mu g/L of both sizes of polystyrene MP. In addition, high throughput sequencing of the 16S rRNA gene V3-V4 region revealed a significant change in the richness and diversity of microbiota in the gut of polystyrene MP-exposed zebrafish. A more in depth analysis, at the genus level, revealed that a total of 29 gut microbes identified by operational taxonomic unit (OTU) analysis were significantly changed in both 0.5 and 50 mu m-diameter polystyrene MP-treated groups. Moreover, it was observed that 0.5 mu m polystyrene MP not only increased mRNA levels of IL1 alpha, IL1 beta and IFN but also their protein levels in the gut, indicating that inflammation occurred after polystyrene MP exposure. Our findings suggest that polystyrene MP could induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. (C) 2017 Elsevier Ltd. All rights reserved.
机译：微塑料（MP）是环境污染物，有可能引起不同程度的水生毒性。在这项研究中，评估了暴露于100和1000μg / L两种尺寸的聚苯乙烯MP 14天的成年雄性斑马鱼对肠道菌群的影响。直径为0.5和50μm的球形聚苯乙烯MP在浓度为1000 a（0.5μm和1.456 x 10（4）颗粒/ L的浓度为1000 a（约1.456 x 10（10）颗粒/ L）时增加了肠液中的粘液体积。 50微米）。在门区域，暴露于两种大小的聚苯乙烯MP 1000μg/ L 14天后，肠道中的拟杆菌和变形杆菌的丰度显着降低，而纤毛虫的丰度显着提高。此外，对16S rRNA基因V3-V4区的高通量测序显示，暴露于聚苯乙烯MP的斑马鱼肠道中微生物群的丰富度和多样性发生了显着变化。在属水平上进行的更深入的分析显示，通过操作分类单位（OTU）分析鉴定出的总共29种肠道微生物在直径为0.5和50微米的聚苯乙烯MP处理组中均发生了显着变化。此外，观察到0.5μm的聚苯乙烯MP不仅增加了IL1α，IL1β和IFN的mRNA水平，而且增加了它们在肠中的蛋白质水平，表明在暴露于聚苯乙烯MP后发炎。我们的发现表明，聚苯乙烯MP可以诱导成年斑马鱼肠道中的微生物群失调和炎症。 （C）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2018年第4期|322-329|共8页
  • 作者

    Jin Yuanxiang; Xia Jizhou; Pan Zihong; Yang Jiajing; Wang Wenchao; Fu Zhengwei;

  • 作者单位

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Polystyrene microplastic; Microbiota dysbiosis; Inflammation; Gut; Zebrafish;

    机译：聚苯乙烯微塑料;微生物群失调;炎症;肠;斑马鱼;

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