...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Pollution >Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances affects leukocyte telomere length in female newborns
【24h】

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances affects leukocyte telomere length in female newborns

机译：产前暴露于全氟烷基和多氟烷基物质会影响女性新生儿白细胞端粒的长度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Evidence has shown that leukocyte telomere length (LTL) at birth is related to the susceptibility to various diseases in later life and the setting of newborn LTL is influenced by the intrauterine environment. Perfluoroalkyl and polyfluoroalkyl substances (PFAS5), as a kind of persistent organic pollutants, are commonly used in commercial and domestic applications and are capable of crossing the maternal fetal barrier during pregnancy. We hypothesized that intrauterine exposure to PFAS5 may affect fetal LTL by increasing oxidative stress. To verify this hypothesis, LTL, concentrations of PFAS5 and reactive oxygen species (ROS) were measured in umbilical cord blood of 581 newborns from a prospective cohort. Our results showed that there were interactions between PFOS/PFDA and sex on LTL and ROS. The LTL was significantly shorter (0.926 +/- 0.053 vs 0.945 +/- 0.054, P=.023 for PFOS; 0.919 +/- 0.063 vs 0.940 +/- 0.059, P=.011 for PFDA) and the ROS levels were extremely higher (252.9 +/- 60.5 [M] vs 233.5 +/- 53.6 [M], P=.031 for PFOS; 255.2 +/- 62.9 [M] vs 232.9 +/- 58.3 [M], P=.011 for PFDA) in the female newborns whose PFOS or PFDA concentrations fell in the upmost quartile compared with those in the lowest quartile after adjusting for potential confounders. ROS levels were inversely associated with LTL in female newborns (beta= -1.42 x 10(-4), P=.022). 13% of the effect of PFOS on female LTL was mediated through ROS approximately by the mediation analyses. However, in male newborns, no relationships among PFASs, ROS and LTL were observed. Our findings suggest a "programming" role of PFASs on fetal telomere biology system in females in intrauterine stage. (C) 2018 Elsevier Ltd. All rights reserved.
机译：有证据表明，出生时白细胞端粒长度（LTL）与以后生活中对各种疾病的易感性有关，而新生儿LTL的形成受宫内环境的影响。全氟烷基和多氟烷基物质（PFAS5）作为一种持久性有机污染物，常用于商业和家庭应用中，并且能够在怀孕期间突破母体的胎儿屏障。我们假设宫内暴露于PFAS5可能通过增加氧化应激影响胎儿LTL。为了验证这一假设，在前瞻性队列的581例新生儿的脐带血中测量了LTL，PFAS5的浓度和活性氧（ROS）。我们的结果表明，PFOS / PFDA与性，LTL和ROS之间存在相互作用。 LTL明显更短（PFOS为0.926 +/- 0.053 vs.0.945 +/- 0.054，P = .023; PFDA为0.919 +/- 0.063 vs 0.940 +/- 0.059，P = .011），并且ROS水平非常高更高（252.9 +/- 60.5 [M]与233.5 +/- 53.6 [M]，对于PFOS为P = .031; 255.2 +/- 62.9 [M]与232.9 +/- 58.3 [M]，对于POS为.011校正潜在混杂因素后，PFOS或PFDA浓度下降的女性新生儿在最高四分位数与最低四分位数相比。在女性新生儿中，ROS水平与LTL呈负相关（β= -1.42 x 10（-4），P = .022）。全氟辛烷磺酸对雌性LTL的影响的13％大约是通过中介分析通过ROS介导的。但是，在男性新生儿中，未观察到PFAS，ROS和LTL之间的关系。我们的研究结果表明，PFAS在子宫内的女性胎儿端粒生物学系统中具有“编程”作用。 （C）2018 Elsevier Ltd.保留所有权利。

著录项

  • 来源
    《Environmental Pollution》 |2018年第4期|446-452|共7页
  • 作者

    Liu Han; Chen Qian; Lei Lei; Zhou Wei; Huang Lisu; Zhang Jun; Chen Dan;

  • 作者单位

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Minist Educ, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Minist Educ, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

    Tongji Univ, Sch Med, East Hosp, Dept Obstet & Gynecol, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Minist Educ, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Pediat Dept, Shanghai, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Minist Educ, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

    Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Minist Educ, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Perfluoroalkyl and polyfluoroalkyl substances; Leukocyte telomere length; Cord blood; Reactive oxygen species;

    机译：全氟烷基和多氟烷基物质;白细胞端粒长度;脐血;活性氧;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号