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A review of the pharmaceutical exposome in aquatic fauna

机译：水生动物中药物暴露的综述

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摘要

Pharmaceuticals have been considered 'contaminants of emerging concern' for more than 20 years. In that time, many laboratory studies have sought to identify hazard and assess risk in the aquatic environment, whilst field studies have searched for targeted candidates and occurrence trends using advanced analytical techniques. However, a lack of a systematic approach to the detection and quantification of pharmaceuticals has provided a fragmented literature of serendipitous approaches. Evaluation of the extent of the risk for the plethora of human and veterinary pharmaceuticals available requires the reliable measurement of trace levels of contaminants across different environmental compartments (water, sediment, biota-of which biota has been largely neglected). The focus on pharmaceutical concentrations in surface waters and other exposure media have therefore limited both the characterisation of the exposome in aquatic wildlife and the understanding of cause and effect relationships. Here, we compile the current analytical approaches and available occurrence and accumulation data in biota to review the current state of research in the field. Our analysis provides evidence in support of the 'Matthew Effect' and raises critical questions about the use of targeted analyte lists for biomonitoring. We provide six recommendations to stimulate and improve future research avenues. (C) 2018 The Authors. Published by Elsevier Ltd.
机译：二十多年来，人们一直将药物视为“新出现的污染物”。那时，许多实验室研究都试图识别水生环境中的危害并评估其风险，而现场研究则使用高级分析技术来寻找目标候选物和发生趋势。然而，缺乏用于药物检测和定量的系统方法提供了偶然方法的零散文献。评估大量可用的人类和兽用药物的风险程度要求可靠地测量跨不同环境区室（水，沉积物，生物区系的生物群，其中大部分生物群已被忽略）的痕量污染物。因此，对地表水和其他接触介质中药物浓度的关注既限制了水生野生生物中暴露体的表征，也限制了对因果关系的理解。在这里，我们汇编了当前的分析方法以及生物区系中可用的发生和积累数据，以回顾该领域的研究现状。我们的分析提供了支持“马修效应”的证据，并提出了有关使用目标分析物清单进行生物监测的关键问题。我们提供了六项建议，以刺激和改善未来的研究途径。 （C）2018作者。由Elsevier Ltd.发布

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  • 来源
    《Environmental Pollution》 |2018年第8期|129-146|共18页
  • 作者

    Miller Thomas H.; Bury Nicolas R.; Owen Stewart F.; MacRae James I.; Barron Leon P.;

  • 作者单位

    Kings Coll London, Fac Life Sci & Med, Analyt & Environm Sci Div, 150 Stamford St, London SE1 9NH, England;

    Univ Suffolk, Fac Sci Hlth & Technol, James Hehir Bldg,Univ Ave, Ipswich IP3 0FS, Suffolk, England;

    AstraZeneca, Global Environm, Alderley Pk, Macclesfield SK10 4TF, Cheshire, England;

    Francis Crick Inst, Metabol Lab, 1 Midland Rd, London NW1 1AT, England;

    Kings Coll London, Fac Life Sci & Med, Analyt & Environm Sci Div, 150 Stamford St, London SE1 9NH, England;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Occurrence; Pharmaceuticals; Fish; Bioconcentration; Invertebrates;

    机译：发生;药物;鱼;生物浓缩;无脊椎动物;

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