Partitioning of hexachlorobenzene between human milk and blood lipid

Murinova Lubica Palkovicova; Wimmerova Sona; Lancz Kinga; Patayova Henrieta; Kostiakova Vladimira; Richterova Denisa; Govarts Eva; Jusko Todd A.; Trnovec Tomas

首页> 外文期刊>Environmental Pollution >Partitioning of hexachlorobenzene between human milk and blood lipid

【24h】

Partitioning of hexachlorobenzene between human milk and blood lipid

机译：六氯苯在人乳和血脂之间的分配

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In epidemiological studies on the toxic effects of prenatal exposure to hexachlorobenzene (HCB), researchers report HCB concentrations, either as wet-weight or per lipid weight basis, in matrices like breast milk, and maternal and cord blood. Conversion of exposures across matrices is needed for comparisons of concentrations and dose effect across cohorts. Using data from a birth cohort study in eastern Slovakia, we derived the maternal blood to cord blood HCB concentration ratio utilizing measured concentrations in 1027 paired maternal and cord blood samples, on a per-lipid basis. In addition to data from the Slovak study, the maternal milk to maternal serum ratio was summarized from 23 published studies on partitioning of HCB between human milk lipid and blood lipid. We identified two distinct groups of milk:blood ratios, those <= 0.45 and those >= 0.85. We assumed that using partition ratios <= 0.45 will underestimate HCB exposure estimates. Taking into account this precautionary measure, we suggest a conversion ratio of 1.21, which is the median of the 16 ratios identified in our literature review. We consider our estimate as conservative and providing appropriate safety in risk analysis. (C) 2017 Elsevier Ltd. All rights reserved.

机译：在关于产前暴露于六氯苯（HCB）的毒性影响的流行病学研究中，研究人员报告了母乳，母体和脐带血等基质中的HCB浓度（以湿重或每脂重计）。需要比较跨矩阵的暴露量，以比较跨队列的浓度和剂量效应。使用来自斯洛伐克东部的一个出生队列研究的数据，我们基于每个血脂，利用1027对成对的母体和脐带血样本中的测量浓度，得出了母血与脐带血HCB浓度比。除了来自斯洛伐克研究的数据外，还从23篇有关HCB在人乳脂和血脂之间分配的公开研究中总结了母乳与母体血清比率。我们确定了两组牛奶：血液比率，分别为<= 0.45和> = 0.85。我们假设使用小于等于0.45的分配比率会低估HCB暴露估算。考虑到这种预防措施，我们建议转换率为1.21，这是我们文献综述中确定的16个比率的中位数。我们认为我们的估计是保守的，并在风险分析中提供适当的安全性。（C）2017 Elsevier Ltd.保留所有权利。

著录项

来源
《Environmental Pollution》 |2017年第10期|994-999|共6页
作者
Murinova Lubica Palkovicova; Wimmerova Sona; Lancz Kinga; Patayova Henrieta; Kostiakova Vladimira; Richterova Denisa; Govarts Eva; Jusko Todd A.; Trnovec Tomas;
展开▼
作者单位

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

VITO NV, Unit Environm Risk & Hlth, Boeretang 200, B-2400 Mol, Belgium;

Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, 265 Crittenden Blvd,CU 420644, Rochester, NY 14642 USA|Univ Rochester, Sch Med & Dent, Dept Environm Med, 265 Crittenden Blvd,CU 420644, Rochester, NY 14642 USA;

Slovak Med Univ, Fac Publ Hlth, Dept Environm Med, Limbova 12, Bratislava 83303, Slovakia;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
Concentration conversion; Hexachlorobenzene; Breast milk; Cord blood; Lipids; Partitioning;

机译：浓度换算;六氯苯;母乳;脐带血;脂质;分配;

相似文献

外文文献
中文文献
专利

1. Rapid communication: partitioning of persistent lipophilic compounds, including dioxins, between human milk lipid and blood lipid: an initial assessment. [J] . Aylward LL, Hays SM, LaKind JS, Journal of toxicology and environmental health, Part A . 2003,第1期

机译：快速沟通：在人乳脂和血脂之间分配持久性亲脂性化合物（包括二恶英）：初步评估。
2. Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk [J] . Hsiao-Ling Huang, Lu-Te Chuang, Hsi-Hsin Li, Lipids in Health Disease . 2013,第3期

机译：金门地区台湾妇女的孕产妇和新生儿血浆磷脂和乳脂中的二十二碳六烯酸：孕产妇血液，新生儿血液和母乳中的脂肪酸成分
3. Contribution of protein binding, Lipid partitioning, and asymmetrical transport to drug transfer into milk in mouse versus human [J] . ItoN., ItoK., KoshimichiH., Pharmaceutical research . 2013,第9期

机译：小鼠与人类中蛋白质结合，脂质分配和不对称转运对药物向牛奶中转移的贡献
4. The Pre-Germinated Brown Rice Regulated in Human with Abnormal Blood Lipids and Sugar [C] . Hung Chien Lung 14th ICC cereal and bread congress and forum on fats amp; oils : Science and technology innovation for healthy cereals amp; oils : book of abstracts . 2012

机译：预发芽糙米在人血脂和糖异常中的调控
5. Effects of solubilized cellulose (a viscous dietary fiber) on serum lipids, blood pressure, glucose tolerance, insulin and cholecystokinin metabolism in hypercholesterolemic humans. [D] . Geleva, Daniela. 2001

机译：增溶纤维素（一种粘性膳食纤维）对高胆固醇血症人的血脂，血压，葡萄糖耐量，胰岛素和胆囊收缩素代谢的影响。
6. Partitioning of hexachlorobenzene between human milk and blood lipid [O] . Ľubica Palkovičová Murínová, Soňa Wimmerová, Kinga Lancz, -1

机译：六氯苯在人乳和血脂之间的分配
7. Partitioning of hexachlorobenzene between human milk and blood lipid [O] . Ľubica Palkovičová Murínová, Soňa Wimmerová, Kinga Lancz, 2017

机译：人乳和血脂之间的六氯苯分区
8. WHO Coordinated Proficiency Study for the Determination of PolychlorinatedBiphenyls, Dibenzodioxins and Dibenzofurans in Human Milk and Blood, Cow's Milk and Fish. Results of the Participation of RIVM-LOC in the III+ d Round [R] . de Jong, A. P. J. M., Marsman, J. A., den Hartog, R. S., 1994

机译：世界卫生组织协调熟练研究测定人乳和血液，牛奶和鱼类中的多氯联苯，二苯并二恶英和二苯并呋喃。 RIVm-LOC参与III + d轮的结果

Partitioning of hexachlorobenzene between human milk and blood lipid

摘要

著录项

相似文献

相关主题

期刊订阅