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首页> 外文期刊>Environmental Pollution >Oxidative status in relation to metal pollution and calcium availability in pied flycatcher nestlings - A calcium manipulation experiment
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Oxidative status in relation to metal pollution and calcium availability in pied flycatcher nestlings - A calcium manipulation experiment

机译：捕蝇器幼雏中与金属污染和钙有效性相关的氧化态-钙操纵实验

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摘要

Metal exposure can produce oxidative stress by disrupting the prooxidant/antioxidant balance. It has been suggested that calcium (Ca) may provide protection against metal toxicity in the organism. The objective of this study is to explore the effects of Ca availability and metal pollution on oxidative stress biomarkers in pied flycatcher (Ficedula hypoleuca) nestlings. For this purpose, we performed a Ca supplementation experiment with birds inhabiting a Ca-poor and metal-polluted area in SW Finland. An array of oxidative stress biomarkers (GSH, GSH:GSSG ratio, GPx, GST, CAT, SOD, lipid peroxidation and protein carbonylation) was measured in red blood cells. The effects of antioxidant molecules and oxidative damage on nestling size, growth, fledging success and fledgling number were evaluated. We observed an up-regulation of GST activity and increased protein carbonyl content in the polluted zone, probably related to a combination of higher metal exposure and reduced food quantity and quality in this area. As expected, birds from the unpolluted zone showed higher GSH:GSSG ratio but, unexpectedly, also showed signs of higher lipid peroxidation (not statistically significant, p = 0.056), both responses likely being related with the lower Ca availability. Our study suggests that different measures of oxidative damage are affected by different factors: while damage to proteins was the target of metal exposure/food limitation, poor Ca availability may enhance damage to lipids in growing birds. The intercorrelations found between Ca in plasma, metal exposure and the different oxidative stress biomarkers show that the antioxidant defense is finely regulated to cope with increased oxidative challenges. Finally, our results suggest that the antioxidant status during early development, conditioned by environmental pollution and Ca availability, is one factor affecting nestling survival and fledgling number. (C) 2017 Elsevier Ltd. All rights reserved.
机译：金属暴露会破坏原氧化剂/抗氧化剂的平衡，从而产生氧化应激。已经提出钙（Ca）可以提供针对生物中的金属毒性的保护。这项研究的目的是探讨Ca有效性和金属污染对斑fly（Ficedula hypoleuca）幼鸟氧化应激生物标志物的影响。为此，我们对居住在芬兰西南部缺钙和金属污染地区的鸟类进行了补钙实验。在红细胞中测量了一系列氧化应激生物标记物（GSH，GSH：GSSG比，GPx，GST，CAT，SOD，脂质过氧化和蛋白质羰基化）。评估了抗氧化剂分子和氧化损伤对雏鸟大小，生长，成雏成功和成雏数目的影响。我们观察到了GST活性的上调和污染区蛋白质羰基含量的增加，这可能与该地区较高的金属暴露量和减少的食物数量和质量相关。正如预期的那样，来自未污染区的鸟类显示出较高的GSH：GSSG比，但出乎意料的是，还显示出脂质过氧化作用更高的迹象（无统计学意义，p = 0.056），这两种反应都可能与较低的Ca利用率有关。我们的研究表明，不同程度的氧化损伤措施受不同因素影响：虽然蛋白质的破坏是金属暴露/食物限制的目标，但钙的利用率差可能会增加生长中禽类对脂质的破坏。在血浆中的Ca，金属暴露和不同的氧化应激生物标记之间发现相互关系，表明抗氧化剂的防御能力得到了很好的调节，以应对日益增加的氧化挑战。最后，我们的结果表明，早期发育中的抗氧化剂状态受环境污染和Ca可用性的影响，是影响雏鸟生存和雏鸟数量的因素之一。 （C）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2017年第10期|448-458|共11页
  • 作者

    Espin Silvia; Ruiz Sandra; Sanchez-Virosta Pablo; Lilley Thomas; Eeva Tapio;

  • 作者单位

    Univ Turku, Dept Biol, Turku 20014, Finland|Univ Murcia, Dept Sociosanitary Sci, Area Toxicol, Campus Espinardo, E-30100 Murcia, Spain;

    Univ Turku, Dept Biol, Turku 20014, Finland;

    Univ Turku, Dept Biol, Turku 20014, Finland|Univ Murcia, Dept Sociosanitary Sci, Area Toxicol, Campus Espinardo, E-30100 Murcia, Spain;

    Univ Turku, Dept Biol, Turku 20014, Finland|Univ Liverpool, Inst Integrat Biol, Evolut Ecol & Behav, Biosci Bldg,Crown St, Liverpool L69 7ZB, Merseyside, England;

    Univ Turku, Dept Biol, Turku 20014, Finland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Antioxidant defense; Oxidative stress; Calcium; Fledging success; Passerine;

    机译：抗氧化防御;氧化应激;钙;羽化成功;雀碱;

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