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首页> 外文期刊>Environmental research >Urban particulate matter induces the expression of receptors for early and late adhesion molecules on human monocytes
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Urban particulate matter induces the expression of receptors for early and late adhesion molecules on human monocytes

机译：城市微粒物质诱导人类单核细胞上早期和晚期粘附分子受体的表达

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摘要

Exposure to urban particulate matter (PM) is correlated with increases in the emergence of health services due to adverse events and deaths and is mainly related to cardiorespiratory complications. The translocation of particles from the lung into circulation has been proposed as a factor that may trigger systemic effects. Monocytes may be exposed to PM, and if the monocytes are activated, then they are likely to adhere to endothelial cells in a distant organ due to the expression of receptors for adhesion molecules. In the present study, we evaluated the expression of receptors for adhesion molecules (sLe(x), PSGL-1, LFA-1, VLA-4 and alpha(v)beta(3)) in monocytes (U937 cells) exposed for 3 or 18 h to PM10 (0.001, 0.003, 0.010, 0.030, 0.300, 3 or 30 mu g/mL). Exposed cells were co-cultured with human endothelial cells that were naive or previously exposed to the same particles. When U937 cells were exposed to PM10, similar levels of expression for early and late receptors for adhesion molecules were observed from 30 ng/mL as those induced by TNF-alpha. Cells exposed to particles at concentrations above 30 ng/mL were more adhesive to naive or exposed human endothelial cells. Taken together, our results suggest that it is plausible that activated monocytes may play a role in systemic effects induced by PM10 due to the size distribution of the particles and the concentrations required to trigger the expression of receptors for adhesion molecules in monocytes.
机译：由于不良事件和死亡，城市颗粒物（PM）的暴露与卫生服务的出现增加有关，并且主要与心肺并发症有关。已经提出颗粒从肺转移到循环中是可能触发全身作用的因素。单核细胞可能会暴露于PM，如果单核细胞被激活，则由于粘附分子受体的表达，它们很可能粘附在远处器官的内皮细胞上。在本研究中，我们评估了暴露3的单核细胞（U937细胞）中粘附分子（sLe（x），PSGL-1，LFA-1，VLA-4和alpha（v）beta（3））受体的表达。或PM10（0.001、0.003、0.010、0.030、0.300、3或30μg / mL）18小时。将暴露的细胞与未加工过的或先前暴露于相同颗粒的人内皮细胞共培养。当U937细胞暴露于PM10时，从30 ng / mL观察到粘附分子的早期和晚期受体的表达水平与TNF-α诱导的相似。暴露于浓度高于30 ng / mL的颗粒的细胞对幼稚或暴露的人类内皮细胞更具粘附性。两者合计，我们的结果表明，由于颗粒的尺寸分布和触发单核细胞中粘附分子受体表达所需的浓度，活化的单核细胞可能在PM10诱导的全身效应中发挥作用。

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