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首页> 外文期刊>Environmental research >The impact on T-regulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: A pilot investigation
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The impact on T-regulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: A pilot investigation

机译：甘肃省农村空气污染中暴露于多环芳烃（PAHs）的农村妇女对T调节细胞相关免疫反应的影响：一项初步调查

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摘要

Previous studies found associations between impairments of immune functions and exposure to polycyclic aromatic hydrocarbons (PAHs) in ambient air pollution in the U. S. and China. However, the results remain inconclusive due to the limitations of these studies. In this study, we aimed to examine the direction and magnitude of immune changes related to PAH exposure from household air pollution among rural women living in Gansu, China. Healthy village women (n = 34) were recruited and enrolled in the study. Questionnaires were administered. Blood and urine samples were collected and analyzed during non-heating (September 2017, "summer") and heating (January 2018, "winter") seasons. Urinary 1-hydroxypyrene (1-OHP) was quantified as the biomarker of PAH exposure. To evaluate Treg cell related immune functions, we examined immunoglobulin E (IgE), percent of T-regulatory (Treg) cells, and gene expression of following: forkhead box transcription factor 3 (Foxp3), transforming growth factor-beta (TGF-beta), interleukin 10 (IL-10), and interleukin 35 (IL-35), composed of interleukin-12 alpha (IL-12 alpha) and Epstein-Barr-virus-induced gene 3 (EBi3). Urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to evaluate oxidative DNA damage. The results showed that the concentration of 1-OHP increased from 0.90 to 17.4 mu mol-Cr-1 from summer to winter (p 0.001). Meanwhile, average percent of Treg cells decreased from 5.01% to 1.15% (p 0.001); IgE and mRNA expressions of Foxp3, TGF-beta, IL-10, IL-12 alpha and EBi3 all significantly decreased (p 0.001); Urinary 8-OHdG increased from 12.7 to 30.3 ng mg-Cr-1 (p 0.001). The changes in 8-OHdG, Foxp3 and TGF-beta were significantly associated with the increase of 1-OHP. The results suggested that we observed a substantial increase of PAH exposure in winter, which was significantly associated with the repression on Treg cell function and oxidative DNA damage. Exposure to PAHs in household air pollution possibly induced immune impairments among rural women in northwest China.
机译：先前的研究发现，在美国和中国，免疫功能受损与环境空气污染中暴露于多环芳烃（PAHs）之间存在关联。但是，由于这些研究的局限性，结果仍然没有定论。在这项研究中，我们旨在研究居住在中国甘肃农村妇女中与家庭空气污染引起的多环芳烃接触有关的免疫变化的方向和强度。招募了健康的农村妇女（n = 34）并参加了研究。进行问卷调查。在非供暖（2017年9月，“夏季”）和供暖（2018年1月，“冬季”）季节收集和分析血液和尿液样本。尿中1-羟基py（1-OHP）被量化为PAH暴露的生物标志物。为了评估Treg细胞相关的免疫功能，我们检查了免疫球蛋白E（IgE），T调节（Treg）细胞的百分比以及以下基因的表达：叉头盒转录因子3（Foxp3），转化生长因子-beta（TGF-beta ），白介素10（IL-10）和白介素35（IL-35），由白介素12 alpha（IL-12 alpha）和爱泼斯坦-巴尔病毒诱导的基因3（EBi3）组成。测量了尿中的8-羟基-2-脱氧鸟苷（8-OHdG）以评估氧化性DNA损伤。结果表明，从夏季到冬季，1-OHP的浓度从0.90增加到17.4μmol-Cr-1（p <0.001）。同时，Treg细胞的平均百分比从5.01％降至1.15％（p <0.001）； Foxp3，TGF-β，IL-10，IL-12 alpha和EBi3的IgE和mRNA表达均显着降低（p <0.001）；尿中的8-OHdG从12.7 ng增加到30.3 ng mg-Cr-1（p <0.001）。 8-OHdG，Foxp3和TGF-β的变化与1-OHP的增加显着相关。结果表明，我们观察到冬季PAH暴露量显着增加，这与抑制Treg细胞功能和氧化DNA损伤显着相关。暴露在家庭空气污染中的PAHs可能会导致中国西北农村妇女的免疫功能受损。

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  • 来源
    《Environmental research》 |2019年第6期|306-317|共12页
  • 作者

    Yao Yueli; Wang Dong; Ma Haitao; Li Chengyun; Chang Xiaoru; Low Patrick; Hammond S. Katharine; Turyk Mary Ellen; Wang Junling; Liu Sa;

  • 作者单位

    Lanzhou Univ, Sch Publ Hlth, Dept Toxicol, Lanzhou 730000, Gansu, Peoples R China;

    Lanzhou Univ, Sch Publ Hlth, Dept Toxicol, Lanzhou 730000, Gansu, Peoples R China;

    Lanzhou Univ, Sch Publ Hlth, Dept Toxicol, Lanzhou 730000, Gansu, Peoples R China;

    Lanzhou Univ, Sch Publ Hlth, Dept Toxicol, Lanzhou 730000, Gansu, Peoples R China;

    Southeast Univ, Sch Publ Hlth, Key Lab Environm Med & Engn, Minist Educ, Nanjing, Jiangsu, Peoples R China;

    Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA;

    Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA;

    Univ Illinois, Sch Publ Hlth, Chicago, IL USA;

    Lanzhou Univ, Sch Publ Hlth, Dept Toxicol, Lanzhou 730000, Gansu, Peoples R China;

    Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA|Purdue Univ, Coll Hlth & Human Sci, Sch Hlth Sci, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Household air pollution; 1-OHP; Immune system; Treg cell; Cytokines; 8-OHdG;

    机译：家庭空气污染;1-OHP;免疫系统;Treg细胞;细胞因子;8-OHdG;

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