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首页> 外文期刊>Environmental research >Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407)
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Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407)

机译：柠檬酸酯增塑剂和邻苯二甲酸二（2-乙基己基）酯在OECD 28天重复剂量毒性试验中的作用（OECD TG 407）

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Citrate esters are considered functional alternatives to phthalate plasticizers, but their toxicity remains poorly understood. The toxicity of citrate esters, including triethyl 2-acetylcitrate (ATEC) and trihexyl O-acetylcitrate (ATHC), were examined together with that of bis (2-ethylhexyl) phthalate (DEHP) using the Organization for Economic Co-operation and Development Test Guideline 407 (OECD TG407). Following 28-day oral administration, no significant differences in body weight or the weight of the brain, pituitary, heart, epididymis, seminal vesicles, or coagulating gland were found between the vehicle control and DEHP, ATEC or ATHC groups. In the 400 mg/kg day DEHP group, liver, adrenal, thymus, spleen, kidney, testis, and prostate weights were significantly increased. In the 400 mg/kg day ATHC group, kidney, adrenal, thymus, testis and prostate weights were significantly increased. In the 400 mg/kg day ATEC group, kidney, adrenal and testis weights were significantly increased. Hepatocyte size was significantly increased in the 400 mg/kg day DEHP group, suggestive of hepatotoxicity, but was not increased in the ATEC or ATHC groups. There were no significant differences in white blood cell, red blood cell or platelet counts, hemoglobin concentrations, hematocrit, mean corpuscular volume, fasting glucose, insulin, or testosterone concentrations between the vehicle control and DEHP, ATEC and ATHC groups. In the ATHC 400 mg/kg day group, T3 was decreased while T4 was increased, suggestive of disruption of thyroid function. The results of the OECD TG407 subacute repeated dosing toxicity test indicate ATEC is less toxic compared to ATHC or DEHP and could be recommended as an alternative to phthalate plasticizers.
机译：柠檬酸酯被认为是邻苯二甲酸酯增塑剂的功能替代品，但其毒性仍知之甚少。使用经济合作与发展组织测试了包括2-乙酰柠檬酸三乙酯（ATEC）和邻乙酰基柠檬酸三己酯（ATHC）在内的柠檬酸酯的毒性，以及邻苯二甲酸二（2-乙基己基）酯的毒性。准则407（OECD TG407）。口服28天后，在对照组和DEHP，ATEC或ATHC组之间，体重或脑，垂体，心脏，附睾，精囊或凝结腺的重量均无显着差异。在每天400 mg / kg的DEHP组中，肝脏，肾上腺，胸腺，脾脏，肾脏，睾丸和前列腺的重量显着增加。在每天400 mg / kg的ATHC组中，肾脏，肾上腺，胸腺，睾丸和前列腺的重量显着增加。在每天400 mg / kg的ATEC组中，肾脏，肾上腺和睾丸的重量显着增加。在每天400 mg / kg的DEHP组中，肝细胞大小显着增加，提示有肝毒性，但在ATEC或ATHC组中则没有增加。载体对照与DEHP，ATEC和ATHC组之间的白细胞，红细胞或血小板计数，血红蛋白浓度，血细胞比容，平均红细胞体积，空腹葡萄糖，胰岛素或睾丸激素浓度无显着差异。在ATHC 400 mg / kg日组中，T3降低而T4升高，提示甲状腺功能破坏。经合组织TG407亚急性重复给药毒性试验的结果表明，与ATHC或DEHP相比，ATEC的毒性较小，因此可以推荐作为邻苯二甲酸酯类增塑剂的替代品。

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