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首页> 外文期刊>Environmental research >Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data
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Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

机译：根据人类生物监测数据，斯洛文尼亚人口中双酚A的风险特征

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摘要

The current study aims to characterize exposure and risk associated to bisphenol-A (BPA) exposure in Slovenia, starting from biomonitoring data. Based on the urinary data, daily intake for the individuals was back-calculated using a physiology based biokinetic (PBBK) model properly parameterized for BPA, coupled with an exposure reconstruction algorithm. Re-running the PBBK model in forward mode allowed the estimation of biologically effective dose (free plasma BPA) and the respective daily area under the curve (AUC). Finally, risk characterization ratio was derived using both external and internal dose metrics. The urinary BPA levels were found low, with GM of 0.79, 1.51 and 0.20 mu g/g creatinine for mothers, children and fathers respectively, similar to the levels of other European countries. Based on the above and accounting for the dynamics of exposure and biokinetics, daily intake was estimated, median exposure levels have been estimated equal to 0.019, 0.035 and 0.005 mu g/kg_bw/d for mothers, fathers and children respectively. The highest estimated intake level was found in a child, equal to 0.87 mu g/kg_bw/d, while the maximum intake for mothers and fathers were 0.7 and 0.8 mu g/kg_bw/d respectively. The respective RCR levels using the EFSA t-TDI of 4 mu g/kg_bw/d were 2 magnitudes of order lower below 1, independently of the selected method. It has to be noted that had daily intake been estimated solely based on the urinary concentrations mass balance, the estimated intake would be lower, as a result of the oversimplification on exposure and elimination time dynamics. This highlights the importance for using PBBK modelling based exposure reconstruction schemes for rapidly metabolized and excreted compounds such as BPA, as well as the study design of efficient sampling for rapidly metabolized compounds.
机译：当前的研究旨在从生物监测数据开始，对斯洛文尼亚的双酚A（BPA）暴露及其相关风险进行表征。基于尿液数据，使用针对BPA正确设置参数的基于生理的生物动力学（PBBK）模型，结合暴露重建算法，对个体的每日摄入量进行反算。以正向模式重新运行PBBK模型可以估算生物有效剂量（游离血浆BPA）和曲线下的各个日面积（AUC）。最后，使用外部和内部剂量指标得出风险特征比。发现尿中双酚A水平较低，母亲，儿童和父亲的GM分别为0.79、1.51和0.20μg/ g肌酐，与其他欧洲国家的水平相似。基于上述情况，并考虑到暴露和生物动力学的动态，估算了每日摄入量，母亲，父亲和孩子的中位暴露水平分别估计为0.019、0.035和0.005μg / kg_bw / d。估计儿童的最高摄入量为0.87μg/ kg_bw / d，而父亲和母亲的最大摄入量分别为0.7μg/ kg_bw / d。使用EFSA t-TDI的4μg / kg_bw / d的各个RCR水平分别为2个数量级，低于1，低于所选方法。必须注意的是，如果仅根据尿液浓度的质量平衡来估算每日摄入量，则由于过度简化了暴露时间和消除时间的动态，估计的摄入量将会更低。这凸显了使用基于PBBK模型的暴露重建方案对快速代谢和排泄的化合物（例如BPA）以及快速代谢化合物的有效采样研究设计的重要性。

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  • 来源
    《Environmental research》 |2019年第3期|293-300|共8页
  • 作者

    Sarigiannis Dimosthenis A.; Tratnik Janja Snoj; Mazej Darja; Kosjek Tina; Heath Ester; Horvat Milena; Anesti Ourania; Karakitsios Spyros P.;

  • 作者单位

    Aristotle Univ Thessaloniki, Dept Chem Engn, Environm Engn Lab, Univ Campus,Bldg D,Rm 201, Thessaloniki 54124, Greece|Aristotle Univ Thessaloniki, HERACLES Res Ctr Exposome & Hlth, Ctr Interdisciplinary Res & Innovat, Balkan Ctr, Bldg B,10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece|Sch Adv Study IUSS, Piazza Vittoria 15, I-27100 Pavia, Italy;

    Josef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia|Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia;

    Josef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia;

    Josef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia|Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia;

    Josef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia|Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia;

    Josef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia|Jozef Stefan Int Postgrad Sch, Ljubljana, Slovenia;

    Aristotle Univ Thessaloniki, HERACLES Res Ctr Exposome & Hlth, Ctr Interdisciplinary Res & Innovat, Balkan Ctr, Bldg B,10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece;

    Aristotle Univ Thessaloniki, Dept Chem Engn, Environm Engn Lab, Univ Campus,Bldg D,Rm 201, Thessaloniki 54124, Greece|Aristotle Univ Thessaloniki, HERACLES Res Ctr Exposome & Hlth, Ctr Interdisciplinary Res & Innovat, Balkan Ctr, Bldg B,10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece|Sch Adv Study IUSS, Piazza Vittoria 15, I-27100 Pavia, Italy;

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  • 正文语种 eng
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  • 关键词

    Human biomonitoring data; Risk assessment; PBBK; Internal dose; Exposure reconstruction; Bisphenol A;

    机译：人体生物监测数据;风险评估;PBBK;内部剂量;暴露重建;双酚A;

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