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首页> 外文期刊>Environmental research >Ambient air pollution during pregnancy and risk of gestational diabetes in New York City
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Ambient air pollution during pregnancy and risk of gestational diabetes in New York City

机译：纽约市怀孕期间的环境空气污染和妊娠糖尿病的风险

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Background: Emerging evidence suggests a potential association between ambient air pollution and risk of gestational diabetes mellitus (GDM), but results have been inconsistent. Accordingly, we assessed the associations between ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) levels with risk of GDM.Methods: Using linked data from birth certificates, hospital discharge diagnoses, and air pollution estimates informed by the New York City Community Air Survey, we fit conditional logistic regression models to evaluate the association between residential levels of PM2.5 and NO2 with risk of GDM among 256,372 singleton live births of non-smoking mothers in New York City born 2008-2010, adjusting for sociodemographic factors and stratified on zip code of maternal address.Results: GDM was identified in 17,065 women, yielding a risk of GDM in the study sample of 67 per 1000 deliveries. In single pollutant models, 1st and 2nd trimester PM2.5 was associated with a lower and higher risk of GDM, respectively. In models mutually adjusting for PM2.5 levels in both trimesters, GDM was associated with PM2.5 levels in the 2nd trimester (OR: 1.06, 95% CI: 1.02, 1.10 per interquartile range increase in PM2.5), but not the 1st trimester (OR: 0.99, 95% CI: 0.96, 1.02). Conversely, GDM was associated with NO2 during the 1st trimester (OR: 1.05, 95% CI: 1.01, 1.09), but not the 2nd trimester (OR: 1.02, 95% CI: 0.98, 1.06). The positive associations between pollutants and GDM were robust to different model specifications. PM2.5 in the 2nd trimester was more strongly associated with GDM among mothers who were aged 35 years and not Medicaid recipients. NO2 in the 1st trimester was more strongly associated with GDM among overweight and parous women.Conclusions: In this large cohort of singleton births in New York City, NO2 in the 1st trimester and PM2.5 in the 2nd trimester were associated with higher odds of GDM, while 1st trimester PM2.5 was weakly and inconsistently associated with lower odds of GDM.
机译：背景：新兴证据表明环境空气污染与妊娠糖尿病（GDM）的风险之间可能存在关联，但结果不一致。因此，我们评估了环境细颗粒物（PM2.5）和二氧化氮（NO2）水平与GDM风险之间的关联。方法：使用出生证，医院出院诊断和纽约提供的空气污染估计值的链接数据在城市社区空气调查中，我们使用条件逻辑回归模型来评估2008年至2010年在纽约市出生的256,372名非吸烟母亲的单胎活产中PM2.5和NO2的居住水平与GDM风险之间的关联，并根据社会人口统计学进行了调整结果：在17065名妇女中发现了GDM，在研究样本中每1000例分娩中有67例发生GDM。在单一污染物模型中，孕早期和孕中期PM2.5分别具有较低和较高的GDM风险。在两个孕期都可同时调整PM2.5水平的模型中，GDM与孕中期的PM2.5水平相关（OR：1.06、95％CI：1.02，PM2.5每四分位数范围的增加1.10），但与孕早期（OR：0.99，95％CI：0.96，1.02）。相反，GDM在孕早期（OR：1.05，95％CI：1.01，1.09）与NO2相关，但在孕中期未与NO2相关（OR：1.02，95％CI：0.98，1.06）。污染物与GDM之间的正相关性对不同的模型规范具有鲁棒性。在孕中期<35岁且未接受医疗补助的母亲中，妊娠中期PM2.5与GDM的相关性更高。结论：在纽约市这一庞大的单胎婴儿队列中，孕早期的二氧化氮与GDM的相关性更高。结论：在纽约市这一庞大的单胎出生队列中，孕中期的二氧化氮和孕中期的PM2.5与高机率相关。 GDM，而孕早期的PM2.5与GDM发生几率较低的关联性弱且不一致。

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