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首页> 外文期刊>Environmental research >Pesticide exposure and cognitive function: Results from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)
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Pesticide exposure and cognitive function: Results from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD)

机译：农药暴露与认知功能：古希腊与饮食纵向研究（HELIAD）的结果

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摘要

Background: Results from studies to date, regarding the role of chronic pesticide exposure on cognitive function remain contradictory.Objective: To investigate the relationship between self-reported pesticide exposure and cognitive function.Methods: Data from a population-based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece was used. Pesticide exposure classification was based on 1) living in areas that were being sprayed; 2) application of spray insecticides/pesticides in their gardens; and 3) occupational application of sprays. Associations between z-scores of cognitive performance and self-reported pesticide exposure were examined with linear regression analyses. Adjusted models were applied, for all analyses.Results: Non-demented individuals who reported that they had been living in areas near sprayed fields, had poorer neuropsychological performance, compared to those who had never lived in such areas. Sub-analyses revealed poorer performance in language, executive and visual-spatial functioning, and attention. These associations remained after a sensitivity analysis excluding subjects with mild cognitive impairment.Conclusion: Self-reported exposure to pesticides was negatively associated with cognitive performance.
机译：背景：迄今为止，关于长期接触农药对认知功能的作用的研究结果仍然矛盾。目的：探讨自我报告的农药暴露与认知功能之间的关系。方法：基于老年人群的队列研究数据（希腊人对衰老和饮食的纵向调查）被使用。农药暴露的分类基于以下几点：1）生活在被喷雾区域中； 2）在花园中喷洒杀虫剂/农药； 3）职业喷雾剂。通过线性回归分析检查了认知表现的z得分与自我报告的农药暴露之间的关联。结果：非痴呆的人报告说他们生活在喷洒的土地附近，与未曾住过的人相比，其神经心理表现较差。子分析显示语言，执行和视觉空间功能以及注意力方面的表现较差。经过敏感性分析后，这些关联仍然存在，排除了轻度认知障碍的受试者。结论：自我报告的农药暴露与认知能力呈负相关。

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