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首页> 外文期刊>Environmental research >Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years - Polish Mother and Child Cohort
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Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years - Polish Mother and Child Cohort

机译：产前和产后早期邻苯二甲酸盐暴露以及7岁儿童的神经发育-波兰母婴队列

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Phthalates are among the most frequently investigated environmental chemicals influencing children's health and particularly their neuropsychological development. However, the reported effects of these compounds on child behavior, cognitive and psychomotor outcomes are not fully consistent. The aim of this study is to evaluate the associations between prenatal and early postnatal phthalate exposures and child neurodevelopment at age of 7 years. A total of 134 mother-child pairs from Polish Mother and Child Cohort (REPRO PL) constitute the basis for current analysis. Eleven phthalate metabolites were measured in urine samples collected from mothers in the 3rd trimester of pregnancy and from children at the age of 2 years. Child neuropsychological development at early school age (7 years) was assessed by both the Strengths and Difficulties Questionnaire (SDQ) filled by mothers and the Polish adaptation of the Intelligence and Development Scales (IDS) performed by psychologists. Mono-ethyl phthalate (MEP) concentration during pregnancy was significantly associated with increased risk of peer relationship problems in SDQ (OR = 2.7, p = 0.03). The results of the IDS analyses focused on child's cognitive and psychomotor development are not fully conclusive. Negative associations were evident between some phthalates in early childhood period and fluid intelligence and cognition (MEP: beta = -5.2; p = 0.006; beta = -4.2; p = 0.006; mono-n-butyl phthalate (MnBP): beta = -4.9; p = 0.03; beta = - 4.0; p = 0.03; respectively), while positive associations have been found in the prenatal period (mono-2-ethyl-5-oxo-hexyl phthalate (oxo-MEHP): beta = 3.6; p = 0.03 for fluid intelligence; beta = 2.9; p = 0.03 for cognition). Further studies are required in order to elucidate which are the most critical periods of phthalate exposure on children's neurodevelopmental outcomes.
机译：邻苯二甲酸盐是影响儿童健康尤其是其神经心理发育的最常被研究的环境化学物质之一。但是，这些化合物对儿童行为，认知和心理运动结果的影响报道并不完全一致。这项研究的目的是评估7岁时产前和产后早期邻苯二甲酸盐暴露与儿童神经发育之间的关联。来自波兰母婴队列（REPRO PL）的总共134对母子构成了当前分析的基础。在怀孕的第三个月的母亲和2岁的儿童的尿液样本中测量了11种邻苯二甲酸酯代谢物。通过母亲填写的《优势与困难问卷》（SDQ）和心理学家对波兰的《智力与发展量表》（IDS）进行的评估，评估了学龄前儿童（7岁）儿童的神经心理发育情况。怀孕期间邻苯二甲酸单乙酯（MEP）浓度与SDQ中同伴关系问题的风险增加显着相关（OR = 2.7，p = 0.03）。 IDS专注于儿童的认知和心理运动发展的分析结果尚不完全结论。幼儿期的某些邻苯二甲酸酯与体液智力和认知之间存在明显的负相关关系（MEP：β= -5.2; p = 0.006;β= -4.2; p = 0.006;邻苯二甲酸单正丁酯（MnBP）：β=- 4.9； p = 0.03；β=-4.0； p = 0.03；分别），而在产前阶段发现了正相关性（邻苯二甲酸单-2-乙基-5-氧代己酯（oxo-MEHP）：β= 3.6 ；对于流体智力，p = 0.03；对于β= 2.9；对于认知，p = 0.03）。为了阐明哪些是邻苯二甲酸酯暴露对儿童神经发育结局的最关键时期，需要进一步的研究。

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