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首页> 外文期刊>Environmental research >Emerging and legacy brominated flame retardants in the breast milk of first time Irish mothers suggest positive response to restrictions on use of HBCDD and Penta- and Octa-BDE formulations
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Emerging and legacy brominated flame retardants in the breast milk of first time Irish mothers suggest positive response to restrictions on use of HBCDD and Penta- and Octa-BDE formulations

机译：爱尔兰首次母乳中出现的新兴和传统溴化阻燃剂表明，对限制使用HBCDD和五溴二苯醚和八溴二苯醚配方的积极反应

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摘要

The brominated flame retardants (BFRs) hexabromocyclododecane (HBCDD), eight polybrominated diphenyl ethers (PBDEs), and decabromodiphenyl ethane (DBDPE) were measured in 16 pools of human milk from Ireland. Concentrations of BDEs-47, -99, -100, -153, and HBCDD were significantly lower (p ＜ 0.05) than those in Irish human milk collected in 2011. In contrast, concentrations of BDE-209 in our study exceeded those in 2011, and while decabromodiphenyl ethane (DBDPE) was not detected in 2011 it was detected in 3 of our samples. This suggests increased use of DBDPE and that while restrictions on the Penta- and Octa-BDE formulations are reducing human exposure, those on Deca-BDE use have yet to reduce body burdens. Estimated exposures for nursing infants to all target BFRs do not suggest a health concern. A one compartment pharma-cokinetic model was used to predict body burdens arising from BFR intakes via air, dust and diet. While for most targeted BFRs, predicted and observed body burdens derived from our human milk data compared reasonably well; predicted BDE-209 and DBDPE values were substantially lower than observed. This suggests exposure pathways not included in the model like dermal uptake from fabrics may be important, and highlights knowledge gaps about the human half-lives and bioavailability of these contaminants.
机译：在来自爱尔兰的16份母乳中测量了溴化阻燃剂（BFR）六溴环十二烷（HBCDD），八种多溴二苯醚（PBDEs）和十溴二苯乙烷（DBDPE）。 BDEs-47，-99，-100，-153和HBCDD的浓度明显低于2011年收集的爱尔兰母乳中的浓度（p ＜0.05）。相比之下，我们研究中的BDE-209浓度超过了2011年的浓度。 ，尽管在2011年未检测到十溴二苯乙烷（DBDPE），但在我们的3个样品中均检测到了十溴二苯乙烷（DBDPE）。这表明增加了DBDPE的使用，虽然对五溴二苯醚和八溴二苯醚配方的限制正在减少人体暴露，但对十溴二苯醚使用的那些仍未减轻人体负担。估计哺乳期婴儿所有目标BFR的暴露量均未表明对健康的关注。使用一个区室的药代动力学模型来预测由于空气，灰尘和饮食而摄入BFR引起的身体负担。对于大多数目标BFR，从我们的母乳数据得出的预测和观察到的身体负担比较合理;预测的BDE-209和DBDPE值明显低于观察到的值。这表明模型中未包括的暴露途径（例如从织物中摄取皮肤）可能很重要，并突显了有关人类半衰期和这些污染物的生物利用度的知识缺口。

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  • 来源
    《Environmental research》 |2020年第1期|28.1-28.7|共7页
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    School of Physics and the Ryan Institute National University of Ireland Galway H91TK33 Ireland;

    School of Geography Earth & Environmental Sciences University of Birmingham Birmingham B15 2TT UK;

    Obstetrics & Gynaecology University Hospital Galway Galway H91 YR71 Ireland;

    Obstetrics & Gynaecology Coombe Women's & Infants University Hospital Dublin D08 XW7X Ireland;

    Food Safety Authority of Ireland Dublin D01 P2V6 Ireland;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Human biomonitoring; BFRs; DBDPE; Temporal trends;

    机译：人体生物监测;BFR;DBDPE;时间趋势;

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