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首页> 外文期刊>Environmental research >Acute differences in pulse wave velocity, augmentation index, and central pulse pressure following controlled exposures to cookstove air pollution in the Subclinical Tests of Volunteers Exposed to Smoke (SToVES) study
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Acute differences in pulse wave velocity, augmentation index, and central pulse pressure following controlled exposures to cookstove air pollution in the Subclinical Tests of Volunteers Exposed to Smoke (SToVES) study

机译：在暴露于烟气的志愿者的亚临床试验（SToVES）研究中，在受控暴露于炉灶空气污染之后，脉搏波速度，增强指数和中心脉压的急性差异

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摘要

Household air pollution emitted from solid-fuel cookstoves used for domestic cooking is a leading risk factor for morbidity and premature mortality globally. There have been attempts to design and distribute lower emission cookstoves, yet it is unclear if they meaningfully improve health. Using a crossover design, we assessed differences in central aortic hemodynamics and arterial stiffness following controlled exposures to air pollution emitted from five different cookstove technologies compared to a filtered air control. Forty-eight young, healthy participants were assigned to six 2-h controlled treatments of pollution from five different cookstoves and a filtered air control. Each treatment had a target concentration for fine paniculate matter: filtered air control =0 μg/m~3, liquefied petroleum gas = 10 μg/m~3, gasifier = 35 μg/m~3, fan rocket = 100 μg/m~3, rocket elbow = 250 μg/m~3, three stone fire = 500 μg/m~3. Pulse wave velocity (PWV), central augmentation index (AIx), and central pulse pressure (CPP) were measured before and at three time points after each treatment (0, 3, and 24 h). Linear mixed models were used to assess differences in the outcomes for each cookstove treatment compared to control. PWV and CPP were marginally higher 24 h after all cookstove treatments compared to control. For example, PWV was 0.15 m/s higher (95% confidence interval: -0.02, 0.31) and CPP was 0.6 mmHg higher (95% confidence interval: -0.8, 2.1) 24 h after the three stone fire treatment compared to control. The magnitude of the differences compared to control was similar across all cookstove treatments. PWV and CPP had no consistent trends at the other post-treatment time points (0 and 3 h). No consistent trends were observed for AIx at any post-treatment time point. Our findings suggest higher levels of PWV and CPP within 24 h after 2-h controlled treatments of pollution from five different cookstove technologies. The similar magnitude of the differences following each cookstove treatment compared to control may indicate that acute exposures from even the cleanest cookstove technologies can adversely impact these subclinical markers of cardiovascular health, although differences were small and may not be clinically meaningful.
机译：用于家庭烹饪的固体燃料炊具排放的家庭空气污染是全球发病率和过早死亡的主要危险因素。已经进行了设计和分配低排放炊具的尝试，但是尚不清楚它们是否能够显着改善健康状况。使用交叉设计，我们评估了受控的暴露于五种不同灶具技术排放的空气污染与过滤后的空气控制相比在中央主动脉血流动力学和动脉僵硬度方面的差异。将四十八名年轻健康的参与者分配到五种不同的炊具和经过过滤的空气控制中，进行六种2小时制的2小时受控污染处理。每种处理均具有细颗粒物的目标浓度：过滤空气控制= 0μg/ m〜3，液化气= 10μg/ m〜3，气化炉= 35μg/ m〜3，风扇火箭= 100μg/ m〜 3，火箭肘= 250μg/ m〜3，三石弹= 500μg/ m〜3。在每次治疗之前和之后的三个时间点（0、3和24小时）测量脉搏波速度（PWV），中心增强指数（AIx）和中心脉压（CPP）。使用线性混合模型评估每种炉灶处理与对照相比的结果差异。与对照组相比，所有炉灶处理后24小时的PWV和CPP略高。例如，与对照相比，三石烧处理后24小时的PWV高0.15 m / s（95％置信区间：-0.02，0.31），CPP高0.6 mmHg（95％置信区间：-0.8，2.1）。在所有炉灶处理中，与对照相比的差异幅度相似。在其他后处理时间点（0和3小时），PWV和CPP没有一致的趋势。在任何治疗后的时间点都没有观察到一致的趋势。我们的研究结果表明，在5种炊具技术的2小时受控污染处理之后的24小时内，PWV和CPP含量较高。与对照相比，每次炉灶处理后的差异幅度相似，这可能表明即使最干净的炉灶技术引起的急性暴露也会对心血管健康的这些亚临床标志产生不利影响，尽管差异很小并且可能没有临床意义。

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  • 来源
    《Environmental research》 |2020年第1期|19.1-19.9|共9页
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  • 作者单位

    Department of Environmental and Radiological Health Sciences Colorado State University Fort Collins CO USA;

    Department of Medicine University of California San Francisco San Francisco CA USA;

    Division of Cardiovascular Medicine University of Michigan Medical School Ann Arbor MI USA;

    Department of Health and Exercise Science Colorado State University Fort Collins CO USA;

    Environmental Public Health Division United States Environmental Protection Agency Research Triangle Park NC USA;

    Department of Mechanical Engineering Colorado State University Fort Collins CO USA;

    Heart Center of the Rockies Fort Collins CO USA;

    Department of Statistics Colorado State University Fort Collins CO USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Air pollution; Biomass burning; Central hemodynamics; Arterial stiffness; Epidemiology;

    机译：空气污染;生物质燃烧;中心血流动力学;动脉僵硬;流行病学;

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