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首页> 外文期刊>Environmental research >Exposure to lead and vaccine-specific IgG titers in South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE): A longitudinal study
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Exposure to lead and vaccine-specific IgG titers in South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE): A longitudinal study

机译：参加Venda母亲，婴儿及其环境健康检查（VHEMBE）的南非儿童中铅和疫苗特异性IgG滴度的暴露：一项纵向研究

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Background: While successes have been achieved in reducing global exposure to lead, few studies have investigated the potential health effects of low-level exposure (e.g. blood lead levels [BLLs] below the CDC reference level of 5 μg/dL), particularly among children from low- and middle-income countries. In addition, lead is immunotoxic in animals but human data on immune response to vaccines is limited. Our aim was to determine whether low-level exposure to lead is associated with humoral response to vaccines among rural South African children. Methods: We used data from the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), a birth cohort study conducted in Limpopo, South Africa. BLLs were measured in whole blood collected at age 1 year and IgG titers for measles, tetanus and Haemophilus influenzae type B (Hib) were determined at age 3.5 years among 425 fully-vaccinated children. Results: BLLs were low (median = 1.90 μg/dL) and 94% of children had a BLL below 5 μg/dL. Overall, BLLs were associated with higher risks of having IgG titers below the protective limit for tetanus (RR = 1.88 per 10-fold increase; 95%CI = 1.08, 3.24) but not measles (RR = 1.02; 95%CI = 0.26, 3.95) or Hib (RR = 0.96; 95%CI = 0.54, 1.71). BLLs were also associated with low Hib IgG titers among children exposed to HIV in utero and with low measles IgG titers among females. In contrast, the association with measles IgG titers was positive among males. Conclusion: Low-level exposure to lead may compromise the humoral response to vaccines. Children exposed to HIV in utero and females may be particularly susceptible.
机译：背景：虽然在减少全球铅接触方面已取得成功，但很少有研究调查低水平铅对健康的潜在影响（例如，低于CDC参考水平5μg/ dL的血铅水平[BLL]），特别是在儿童中来自中低收入国家。此外，铅在动物中具有免疫毒性，但有关疫苗免疫反应的人类数据有限。我们的目的是确定南非农村儿童对铅的低水平暴露是否与疫苗的体液反应有关。方法：我们使用了来自母亲，婴儿及其环境的Venda健康检查（VHEMBE）的数据，该数据是在南非林波波进行的一项出生队列研究。在1岁时采集的全血中测量BLL，并在425名完全接种疫苗的儿童中于3.5岁时测定了麻疹，破伤风和B型流感嗜血杆菌（Hib）的IgG滴度。结果：BLL较低（中位数= 1.90μg/ dL），94％的儿童BLL低于5μg/ dL。总体而言，BLL与IgG滴度低于破伤风保护极限的风险更高（每增加10倍RR = 1.88; 95％CI = 1.08，3.24），而与麻疹无关（RR = 1.02; 95％CI = 0.26， 3.95）或Hib（RR = 0.96; 95％CI = 0.54，1.71）。在子宫内暴露于HIV的儿童中，BLLs还与低Hib IgG滴度相关，而与女性相比，BLL也与麻疹IgG滴度低相关。相反，在男性中，与麻疹IgG滴度的关联为阳性。结论：低水平接触铅可能会损害疫苗的体液反应。子宫内感染艾滋病毒的儿童和女性可能特别容易感染。

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  • 来源
    《Environmental research》 |2020年第1期|40.1-40.8|共8页
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    Department of Epidemiology Biostatistics and Occupational Health Faculty of Medicine McGill University Montreal Quebec Canada;

    Research Institute of the McGill University Health Centre Montreal Quebec Canada Division of Experimental Medicine Department of Medicine Faculty of Medicine McGill University Montreal Quebec Canada;

    Research Institute of the McGill University Health Centre Montreal Quebec Canada;

    Division of Experimental Medicine Department of Medicine Faculty of Medicine McGill University Montreal Quebec Canada Gerald Bronfman Department of Oncology Faculty of Medicine McGill University Montreal Quebec Canada;

    University of Pretoria Institute for Sustainable Malaria Control and School of Health Systems and Public Health University of Pretoria Pretoria South Africa;

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    Lead; Vaccine response; Measles; Tetanus; Haemophilus influenzae type B; Immunotoxicity; Early childhood vaccines;

    机译：铅;疫苗反应;麻疹;破伤风;乙型流感嗜血杆菌;免疫毒性幼儿疫苗;

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