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首页> 外文期刊>Environmental research >Predictors of urinary phthalate biomarker concentrations in postmenopausal women
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Predictors of urinary phthalate biomarker concentrations in postmenopausal women

机译：绝经后妇女尿邻苯二甲酸盐生物标志物浓度的预测因素

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摘要

Background: Phthalates are ubiquitous endocrine disrupting chemicals present in a wide variety of consumer products. However, the personal characteristics associated with phthalate exposure are unclear.Objectives: We sought to describe personal, behavioral, and reproductive characteristics associated with phthalate metabolite concentrations in an ongoing study nested within the Women's Health Initiative (WHI).Materials and Methods: We measured thirteen phthalate metabolites in two or three archived urine samples collected in 1993-2001 from each of 1257 WHI participants (2991 observations). We fit multivariable generalized estimating equation models to predict urinary biomarker concentrations from personal, behavioral, and reproductive characteristics.Results: Older age was predictive of lower concentrations of monobenzyl phthalate (MBzP), mono-carboxyoctyl phthalate (MCOP), mono-3-carboxypropyl phthalate (MCPP), and the sum of di-n-butyl phthalate metabolites (Sigma DBP). Phthalate metabolite concentrations varied by race/region, with generally higher concentrations observed among non-Whites and women from the West region. Higher neighborhood socioeconomic status predicted lower MBzP concentrations, and higher education predicted lower monoethyl phthalate (MEP) and higher concentrations of the sum of metabolites of di-isobutyl phthalate (Sigma DiBP). Overweight/obesity predicted higher MBzP, MCOP, monocarboxynonyl phthalate (MCNP), MCPP, and the sum of metabolites of di(2-ethylhexyl) phthalate (Sigma DEHP) and lower MEP concentrations. Alcohol consumption predicted higher concentrations of MEP and Sigma DBP, while current smokers had higher Sigma DBP concentrations. Better diet quality as assessed by Healthy Eating Index 2005 scores predicted lower concentrations of MBzP, Sigma DiBP, and Sigma DEHP.Conclusion: Factors predictive of lower biomarker concentrations included increased age and healthy behaviors (e.g. lower alcohol intake, lower body mass index, not smoking, higher quality diet, and moderate physical activity). Racial group (generally higher among non-Whites) and geographic regions (generally higher in Northeast and West compared to South regions) also were predictive of phthalate biomarker concentrations.
机译：背景：邻苯二甲酸盐是普遍存在的内分泌扰乱各种消费产品中存在的化学品。然而，与邻苯二甲酸盐暴露有关的个人特征是不清楚的。目的：我们试图描述与邻苯二甲酸酯代谢物浓度相关的个人，行为和生殖特性，在妇女的健康倡议（WHI）内嵌套。材料和方法：我们测量了1993 - 2001年的两种或三个存档的尿液样本中的十三个邻苯二甲酸酯代谢物从1257名WHI参与者（2991个观察）中的每一个收集。我们适合多变量的广义估计公式模型，以预测个人，行为和生殖特征的尿生物标志物浓度。结果：较旧的年龄是邻苯二甲酸酯（MBZP），单羧基乙二醇酯（MCOP），单羧酸酯，单-3-羧丙基的较低浓度的单苄基浓度的预测性邻苯二甲酸酯（MCPP）和邻苯二甲酸二丁酯代谢物（Sigma DBP）的总和。邻苯二甲酸酯代谢物浓度因种族/地区而异，在西部地区的非白人和女性中观察到的浓度通常较高。邻域社会经济地位的高度MBZP浓度降低，高等教育预测了邻苯二甲酸酯（MEP）的低级甲醇（MEP）和较高浓度的邻苯二甲酸酯（Sigma Dibp）的代谢物和。超重/肥胖预测较高的MBZP，MCOP，单羧酸邻苯二甲酸酯（MCNP），MCPP和二（2-乙基己基）邻苯二甲酸酯（Sigma Dehp）和低MEP浓度的代谢物和。醇消耗预测了更高浓度的MEP和Sigma DBP，而目前的吸烟者具有更高的Sigma DBP浓度。通过健康饮食指标评估的更好的饮食质量预测较低浓度的MBZP，Sigma Dibp和Sigma Dehp.Conclusion：降低生物标志物浓度的因素包括增加的年龄和健康的行为（例如，低级酒精摄入量，降低体重指数，而不是降低体重指数吸烟，更高质量的饮食和适度的身体活动）。种族群（在非白人之间通常更高）和地理区域（与南部地区相比，东北和西部的地理区域）也有邻苯二甲酸盐生物标志物浓度预测。

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  • 来源
    《Environmental research》 |2019年第2期|122-130|共9页
  • 作者

    Reeves Katherine W.; Santana Mary Diaz; Manson Joann E.; Hankinson Susan E.; Zoeller R. Thomas; Bigelow Carol; Hou Lifang; Wactawski-Wende Jean; Liu Simin; Tinker Lesley; Calafat Antonia M.;

  • 作者单位

    Univ Massachusetts Dept Biostat & Epidemiol Amherst MA 01003 USA;

    Univ Massachusetts Dept Biostat & Epidemiol Amherst MA 01003 USA;

    Harvard Med Sch Brigham & Womens Hosp Dept Med Boston MA USA|Harvard TH Chan Sch Publ Hlth Boston MA USA;

    Univ Massachusetts Dept Biostat & Epidemiol Amherst MA 01003 USA;

    Univ Massachusetts Dept Biol Amherst MA 01003 USA;

    Univ Massachusetts Dept Biostat & Epidemiol Amherst MA 01003 USA;

    Northwestern Univ Feinberg Sch Med Robert H Lurie Comprehens Canc Ctr Ctr Populat Epigenet Chicago IL 60611 USA|Northwestern Univ Feinberg Sch Med Dept Prevent Med Chicago IL 60611 USA;

    Univ Buffalo Sch Publ Hlth & Hlth Profess Dept Epidemiol & Environm Hlth Buffalo NY USA;

    Brown Univ Ctr Global Cardiometab Hlth Providence RI 02912 USA|Brown Univ Dept Epidemiol Providence RI 02912 USA|Brown Univ Dept Med Providence RI 02912 USA|Brown Univ Dept Surg Providence RI 02912 USA;

    Fred Hutchinson Canc Res Ctr Canc Prevent Program 1124 Columbia St Seattle WA 98104 USA;

    Ctr Dis Control & Prevent Div Sci Lab Natl Ctr Environm Hlth Atlanta GA 30341 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Phthalates; Postmenopausal; Women;

    机译：邻苯二甲酸盐;绝经后;女性;

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