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首页> 外文期刊>Environmental research >Chlorinated persistent organic pollutants and type 2 diabetes - A population-based study with pre- and post- diagnostic plasma samples
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Chlorinated persistent organic pollutants and type 2 diabetes - A population-based study with pre- and post- diagnostic plasma samples

机译：氯化持久性有机污染物和2型糖尿病 - 一种基于人群的血浆样品和诊断后血浆样本的研究

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Background: Persistent organic pollutants (POPs) have been associated with type 2 diabetes (T2D), but causality is uncertain.Objective: Within longitudinal population-based data from northern Sweden, we assessed how POPs associated with T2D prospectively and cross-sectionally, and further investigated factors related to individual changes in POP concentrations.Methods: For 129 case-controls pairs matched by age, sex and date of sampling, plasma concentrations of hexachlorobenzene (HCB), dichlorodiphenyl-dichloroethylene (p,p'-DDE), dioxin-like (DL) polychlorinated biphenyl congeners (PCB-118 and PCB-156), and non-dioxin like (NDL-PCB: PCB-74, -99, -138-153, -170, -180, -183 and PCB-187) were analyzed twice (baseline and follow-up, 9-20 years apart). The cases received their T2D diagnose between baseline and follow-up. Prospective (using baseline data) and cross-sectional (using follow-up data) odds ratios (ORs) for T2D on lipid standardized POPs (HCB, p,p'-DDE, Sigma DL-PCBs, Sigma NDL-PCBs) were estimated using conditional logistic regression, adjusting for body mass index (BMI) and plasma lipids. The influence of BMI, weight-change, and plasma lipids on longitudinal changes in POP concentrations were evaluated among non-diabetic individuals (n = 306).Results: POPs were associated with T2D in both the prospective and cross-sectional assessments. Of a standard deviation increase in POPs, prospective ORs ranged 1.42 (95% CI: 0.99, 2.06) for Sigma NDL-PCBs to 1.55 (95% CI: 1.01, 2.38) for HCB (p 0.05 only for HCB), and cross-sectional ORs ranged 1.62 (95% CI: 1.13; 2.32) for p,p'-DDE to 2.06 (95% CI: 1.29, 3.28) for Sigma DL-PCBs (p 0.05 for all POPs).In analyses of non-diabetic individuals, higher baseline BMI, decreased weight and decreased plasma lipid concentrations were associated with a slower decrease of POPs. Cases had, besides a higher BMI, reduced cholesterol and weight gain at follow-up compared to controls, which can explain the higher ORs in the cross-sectional assessments.Discussion: The association between POPs and T2D was confirmed, but an indication that individuals body fat history might influence POP-T2D associations weakens the epidemiological support for a causal association. It also warrants studies based on other exposure metrics than biomonitoring. In addition, we note that a crosssectional design overestimates the ORs if T2D cases have successfully intervened on weight and/or blood lipids, as changes in these factors cause changes in POPs.
机译：背景：持久性有机污染物（POPs）与2型糖尿病（T2D）有关，但因果关系是不确定的。目的：在瑞典北部的基于纵向群体的数据中，我们评估了前瞻性和横截面的POPS如何与T2D相关联进一步调查与流行浓度的个体变化有关的因素。方法：对于按年龄，性别和采样日期匹配的129个病例对照，六氯苄苯（HCB）的血浆浓度，二氯己烯基二氯乙烯（P，P'-DDE），二恶英 - 样（DL）聚氯联合氯联苯（PCB-118和PCB-156），以及非二恶英（NDL-PCB：PCB-74，-99，-138-153，-170，-180，-183和PCB） -187）分析了两次（基线和随访，9-20岁）。该病例在基线和后续行动之间接受了他们的T2D诊断。估计脂质标准化Pops（HCB，P，P'-DDE，Sigma DL-PCB）的前瞻性（使用基线数据）和T2D的横截面（使用后续数据）ODDS比率（OR）使用条件逻辑回归，调整体重指数（BMI）和血浆脂质。在非糖尿病个体（n = 306）中，评估了BMI，体重变化和血浆脂质对流行浓度的纵向变化的影响（n = 306）。结果：POP在前瞻性和横截面评估中与T2D相关。 POPS的标准偏差增加，σNDL-PCBS为1.42（95％CI：0.99,2.06），对HCB的1.55（95％CI：1.01,2.38）（仅适用于HCB）和交叉 - Σ-dde至2.06（95％CI：1.13; 2.32）的剖位或者为2.06（95％CI：1.29,3.28），适用于Sigma DL-PCB（所有POP的P <0.05）。在非 - 糖尿病患者，较高的基线BMI，重量减少和降低的血浆脂质浓度较慢的流行速度较慢。除了BMI较高的BMI，与对照相比，患者的胆固醇和后续体重增加，可以解释横断面评估中的较高级别。探讨：POPS和T2D之间的关联被证实，但表明个人体脂历史可能影响Pop-T2D联想削弱了因果关系的流行病学支持。它还认证基于其他曝光度量的研究而不是生物监测。此外，我们注意到，如果T2D病例成功地介入重量和/或血脂，则横截面设计估计或者，因为这些因素的变化导致POPS发生变化。

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