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首页> 外文期刊>Environmental research >Nano-TiO_2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae
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Nano-TiO_2 enhanced bioaccumulation and developmental neurotoxicity of bisphenol a in zebrafish larvae

机译：Nano-TiO_2在斑马鱼幼虫中增强了双酚A的生物累积和发育神经毒性

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摘要

The titanium dioxide nanoparticles (n-TiO_2) could enhance the bioavailability and toxicity of the coexisted organic toxicants in aquatic phase. Parental co-exposure to n-TiO_2 and bisphenol A (BPA) could generate developmental neurotoxicity in unexposed zebrafish offspring. However, it remains unexplored regarding the developmental neurotoxicity in larvae fish after co-exposure during the early developmental stage. In present study, fertilized zebrafish eggs were exposed to TiO_2 nanoparticles (100 μg/L), BPA (1, 4 and 20 μg/L) or their binary mixtures until 6 days post fertilization (dpf). No significant change was observed in hatching, malformation, survival and weight of the larvae among all groups. However, n-TiO_2 significantly increased the body burden of BPA in the 4 and 20 ug/L co-exposure groups, depressed expression of neurodevelopment marker genes (α1-tubulin, mbp and syn2a) as well as the locomotor behavior. The current results indicate that n-TiO_2 could strengthen the developmental neurotoxicity and inactive locomotion in co-exposed zebrafish larvae by promoting the bioaccumulation and bioavailability of BPA, which highlighted the similar toxic risks of developmental neurotoxicity after co-exposure at early developmental stage to that of the parental co-exposure.
机译：二氧化钛纳米颗粒（N-TiO_2）可以增强水生阶段共存有机毒物的生物利用度和毒性。父母的共同暴露于N-TiO_2和双酚A（BPA）可以在未曝光的斑马鱼后代产生发育神经毒性。然而，在早期发育期间，在共同发育期间幼虫鱼类发育神经毒性仍然是未开发的。在目前的研究中，受精斑马鱼蛋暴露于TiO_2纳米颗粒（100μg/ L），BPA（1,4和20μg/ L）或其二元混合物直至受精后6天（DPF）。在所有群体中，在孵化，畸形，幼虫的重量中没有观察到显着变化。然而，N-TiO_2显着增加了4和20 UG / L共曝光组中BPA的体重，抑制了神经发育标记基因（α1-微管蛋白，MBP和SYN2A）以及运动行为。目前的结果表明，N-TiO_2通过促进BPA的生物累积和生物利用度，N-TiO_2可以通过促进BPA的生物累积和生物利用度强化共同暴露的斑马鱼幼虫，这突出了在早期发育阶段的共同暴露后发育神经毒性的类似毒性风险父母的共同暴露。

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  • 来源
    《Environmental research》 |2020年第8期|109682.1-109682.8|共8页
  • 作者

    Juanjuan Fu; Yongyong Guo; Lihua Yang; Jian Han; Bingsheng Zhou;

  • 作者单位

    Stale Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China University of Chinese Academy of Sciences Beijing 100049 China;

    Stale Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China;

    Stale Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China;

    Stale Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China;

    Stale Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Bisphenol A; n-TiO_2; Co-exposure; Bioaccumulation; Neurotoxicity; Zebrafish larvae;

    机译：双酚A;n-tio_2;共同曝光;生物累积;神经毒性;斑马鱼幼虫;

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