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首页> 外文期刊>Environmental research >Prediagnostic serum concentrations of organochlorine pesticides and non-Hodgkin lymphoma: A nested case-control study in the Norwegian Janus Serum Bank Cohort
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Prediagnostic serum concentrations of organochlorine pesticides and non-Hodgkin lymphoma: A nested case-control study in the Norwegian Janus Serum Bank Cohort

机译：有机氯杀虫剂和非霍奇金淋巴瘤的血清血清浓度：挪威Janus血清银行队列中的嵌套案例对照研究

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摘要

Background: Much of the marked increase in incidence of non-Hodgkin lyraphoma (NHL) over the past few decades remains unexplained. Organochlorines, including organochlorine pesticides (OCPs), have been implicated as possible contributors to the increase, but the evidence is inconsistent. Objectives: To investigate the relation between pre-diagnostic levels of OCPs and risk of NHL in a case-control study nested within the population-based Janus Serum Bank Cohort in Norway. Methods: Prediagnostic concentrations of 11 OCPs or OCP metabolites were measured in baseline blood samples collected between 1972 and 1978 from 190 cases and 190 controls matched on sex, county, age at blood draw, and date of blood draw. We conducted conditional logistic regression to estimate adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for each quartile of lipid-corrected OCP/metabolite relative to the lowest quartile. Results: We observed non-significantly elevated ORs across quartiles of (3-hexachlorocyclohexane compared to the lowest quartile (OR range: 1.40-1.82) although with no apparent monotonic exposure-response relationship. We also found an inverse association between risk of NHL and o,p'-DDT (OR for Q_4 vs. Q_1 = 0.44, 95% CI: 0.19, 1.01; p-trend = 0.05). In analyses stratified by age at blood collection and duration of follow-up, several other analytes, primarily chlordane-related compounds, showed inverse associations among younger participants or those with longer follow-up time between blood draw and NHL diagnosis. Conclusions: We found only limited evidence of positive association between selected OCPs and development of NHL.
机译：背景：在过去几十年中，非霍奇金华瘤（NHL）发生率的大部分显着增加仍然是未解释的。有机氯，包括有机氯农药（OCP），与增加的贡献者牵连，但证据不一致。目的：探讨挪威人口林库群落嵌套在嵌套在庭院对照研究中ocps预诊断水平与NHL风险的关系。方法：在1972年至1978年间1972年至1978年间收集的基线血液样品中，从190例和190例对抗匹配的血液抽取，血液征集和血液绘制日期，测量了11个ocP或OCP代谢物的预诊断浓度。我们对脂质校正的OCP /代谢物相对于最低四分位数估计调节的逻辑回归，以估计调整后的大量比率（或95％）和95％置信区间（95％CIs）。结果：我们观察到（与最低四分位数（或1.40-1.82）相比（3-六氯环己烷相比的四分位数（3-六氯环己烷）的非显着升高，尽管没有明显的单调暴露 - 反应关系。我们还发现了NHL风险之间的反比关联O，P'-DDT（或Q_4与Q_1 = 0.44,95％CI：0.19,1.01; p-Trend = 0.05）。在血液收集年龄分层的分析和随访期间，其他几个分析物，主要的氯葡萄酒相关的化合物，表现出年轻参与者之间的逆关联，或者血液抽取和NHL诊断之间具有更长的随访时间的反向关联。结论：我们发现只有有限的表现出在选定的OCP和NHL的发展之间积极关联的证据。

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  • 来源
    《Environmental research》 |2020年第8期|109515.1-109515.9|共9页
  • 作者

    Dazhe Chen; Tom K. Grimsrud; Hilde Langseth; Dana B. Barr; Bryan A. Bassig; Aaron Blair; Kenneth P. Cantor; Marilie D. Gammon; Qing Lan; Nathaniel Rothman; Lawrence S. Engel;

  • 作者单位

    Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill Chapel Hill NC USA;

    Department of Research Cancer Registry of Norway Institute of Population-Based Cancer Research Oslo Norway;

    Department of Research Cancer Registry of Norway Institute of Population-Based Cancer Research Oslo Norway;

    Department of Environmental Health Rollins School of Public Health Emory University Atlanta Georgia;

    Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services Rockville MD USA;

    Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services Rockville MD USA;

    Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services Rockville MD USA;

    Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill Chapel Hill NC USA;

    Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services Rockville MD USA;

    Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services Rockville MD USA;

    Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill Chapel Hill NC USA;

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  • 正文语种 eng
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  • 关键词

    Environmental pollutants; Epidemiology; Non-Hodgkin lymphoma; Organochlorines; Pesticides;

    机译：环境污染物;流行病学;非霍奇金淋巴瘤;有机氯;杀虫剂;

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