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首页> 外文期刊>Environmental research >Metals, autoimmunity, and neuroendocrinology: Is there a connection?
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Metals, autoimmunity, and neuroendocrinology: Is there a connection?

机译：金属，自身免疫和神经内分泌分泌物：是否有连接？

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摘要

It has been demonstrated that metals can induce autoimmunity. However, few studies have attempted to assess and elucidate the underlying mechanisms of action. Recent research has tried to evaluate the possible interactions of the immune system with metal ions, particularly with heavy metals. Research indicates that metals have the potential to induce or promote the development of autoimmunity in humans. Metal-induced inflammation may dysregulate the hypothalamic-pituitary-adrenal (HPA) axis and thus contribute to fatigue and other nonspecific symptoms characterizing disorders related to autoimmune diseases. The toxic effects of several metals are also mediated through free radical formation, cell membrane disturbance, or enzyme inhibition. There are worldwide increases in environmental metal pollution. It is therefore critical that studies on the role of metals in autoimmunity, and neuroendocrine disorders, including effects on the developing immune system and brain and the genetic susceptibility are performed. These studies can lead to efficient preventive strategies and improved therapeutic approaches. In this review, we have retrieved and commented on studies that evaluated the effects of metal toxicity on immune and endocrine-related pathways. This review aims to increase awareness of metals as factors in the onset and progression of autoimmune and neuroendocrine disorders.
机译：已经证明金属可以诱导自身免疫。但是，很少有研究试图评估和阐明基本行动机制。最近的研究试图评估免疫系统与金属离子的可能相互作用，特别是用重金属。研究表明，金属有可能诱导或促进人类自身免疫的发展。金属诱导的炎症可能使下丘脑 - 垂体 - 肾上腺（HPA）轴诱导，从而有助于疲劳和其他非特异性症状，其表征与自身免疫疾病有关的疾病。几种金属的毒性作用也通过自由基形成，细胞膜干扰或酶抑制介导。环境金属污染有全世界增加。因此，研究了关于金属在自身免疫和神经内分泌疾病中的作用的研究，包括对发育免疫系统和脑以及遗传易感性的影响。这些研究可以导致有效的预防策略和改善的治疗方法。在本综述中，我们检索并评论了评估金属毒性对免疫和内分泌相关途径的影响的研究。该审查旨在提高对自身免疫和神经内分泌疾病发病和进展的因素的认识。

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  • 来源
    《Environmental research》 |2020年第8期|109541.1-109541.8|共8页
  • 作者

    Geir Bjorklund; Maryam Dadar; Salvatore Chirumbolo; Jan Aaseth; Massimiliano Peana;

  • 作者单位

    Council for Nutritional and Environmental Medicine Mo i Rana Norway;

    Razi Vaccine and Serum Research Institute Agricultural Research Education and Extension Organization (AREEO) Kara) Iran;

    Department of Neurosciences Biomedicine and Movement Sciences University of Verona Verona Italy CONEM Scientific Secretary Verona Italy;

    Research Department Innlandet Hospital Trust Brumunddal Norway IM Sechenov First Moscow State Medical University (Sechenov University) Moscow Russia;

    Department of Chemistry and Pharmacy University of Sassari Sassari Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Metals; Autoimmunity; Neuroendocrinology;

    机译：金属;自身免疫;神经病药物学;

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