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Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth

机译：暴露于怀孕巴西妇女的每种和多氟化烷基物质及其与胎儿生长的关系

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摘要

Research pertaining to exposure of humans to per- and polyfluorinated alkyl substances (PFASs) has received considerable public and regulatory attention in recent years. Although several studies have reported exposure to PFASs by populations in North America and western Europe, such information is still scarce in Latin America, including Brazil. In this study, concentrations of thirteen PFASs were determined in whole blood collected during the second trimester from 252 pregnant Brazilian women. This is a nested case-control study within the Brazilian Ribeirao Preto and Sao Luiz Birth Cohort Study (BRISA) with selected birth outcomes cases (n = 63) and matched controls (n = 189). PFASs concentrations were associated with conditions including preeclampsia, birth weight (BW), preterm birth, and intrauterine growth restriction (IUGR). Among PFASs measured, per-fluorooctane sulfonate (PFOS) was found at the highest concentration (range: 1.06-106 ng mL~(-1) with a median value of 3.41 ng mL~(-1)) which was followed by perfluorooctanoic acid (PFOA, range: 0.11-2.77 ng mL~(-1) with a median value of 0.20 ng mL~(-1)). A significant positive association of PFOS and PFOA concentrations with fetal growth restriction (p ＜ 0.05) was found. This is the first study to assess whole blood concentrations of PFASs and their effect on fetal growth in pregnant Brazilian women.
机译：近年来，对人类暴露于人和多氟化烷基物质（PFASS）的研究已经得到了大量的公众和监管。虽然有几项研究报告了北美和西欧的群体接触金银，但这些信息仍然稀缺在拉丁美洲，包括巴西。在这项研究中，在来自252名怀孕的巴西女性的第二孕中期收集的全血中测定了13个PFASS的浓度。这是巴西里贝雷岛Preto和Sao Luiz Thallate Cohort研究（Brisa）内的嵌套病例控制研究，具有选定的出生案例（n = 63）和匹配的对照（n = 189）。金属汞浓度与包括预坦克敏，出生体重（BW），早产和宫内生长限制（IUGR）的病症有关的病症。在测量的PFASS中，在最高浓度（范围：1.06-106ng ml〜（-1）的中值为3.41ng ml〜（-1）），其次是全氟辛酸（PFOA，范围：0.11-2.77 ng ml〜（-1），中值值为0.20 ng ml〜（-1））。发现PFOS和PFOA浓度具有胎儿生长限制（P <0.05）的显着阳性关联。这是第一次评估全血浓度的粉粘剂及其对孕妇胎儿生长的影响。

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  • 来源
    《Environmental research》 |2020年第8期|109585.1-109585.7|共7页
  • 作者

    Marilia Cristina Oliveira Souza; Maria Conceicao Pereira Saraiva; Masato Honda; Marco Antonio Barbieri; Heloisa Bettiol; Fernando Barbosa; Kurunthachalam Kannan;

  • 作者单位

    Laboratorio de Toxicologia Analitica e de Sistemas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto Universidade de Sao Paulo Ribeirao Preto Sao Paulo 14040-903 Brazil Department of Pediatrics and Department of Environmental Medicine New York University School of Medicine New York NY 10016 USA;

    Departamento de Clinica Infantil Faculdade de Odontologia de Ribeirao Preto Universidade de Sao Paulo Ribeirao Preto Sao Paulo 14040-904 Brazil;

    Institute of Nature and Environmental Technology Kanazawa University Kakuma Kanazawa Ishikawa Prefecture 920-119 Japan Department of Pediatrics and Department of Environmental Medicine New York University School of Medicine New York NY 10016 USA;

    Departamento de Puericultura e Pediatria da Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo Brazil;

    Departamento de Puericultura e Pediatria da Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo Brazil;

    Laboratorio de Toxicologia Analitica e de Sistemas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto Universidade de Sao Paulo Ribeirao Preto Sao Paulo 14040-903 Brazil;

    Department of Pediatrics and Department of Environmental Medicine New York University School of Medicine New York NY 10016 USA Biochemistry Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia;

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  • 正文语种 eng
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  • 关键词

    Human biomonitoring; Perfluoroalkylated; PFOS; Birth outcomes; Fetal growth;

    机译：人体生物监测;全氟烷基化;PFOS;出生结果;胎儿生长;

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