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Perfluoroalkyl substances exposure and hearing impairment in US adults

机译：全氟烷基物质暴露和听力障碍在美国成年人

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摘要

Background: Per- and polyfluoroalkyl substances (PFAS) are widely applied in consumer and industrial products such as nonstick cookware, waterproof clothing, food packaging materials, and fire-fighting foams. These "forever chemicals" are hypothesized to impact neurobehavioral functions. Yet no previous study has explored the role of PFAS on audiometrically determined hearing impairment (HI). Objectives: To investigate the associations of serum concentrations of perfluoroalkyl substances with low-frequency HI (LFHI) and high-frequency HI (HFHI) in US adults. Methods: We evaluated the cross-sectional associations in 2371 adults aged 20-69 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2003-2004, 2011-2012 and 2015-2016; and 449 adults aged ＞70 years from NHANES 2005-2006 and 2009-2010. Serum concentrations of perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), were measured using solid-phase extraction coupled to High Performance Liquid Chromatography-Turbo Ion Spray ionization-tandem Mass Spectrometry. LFHI was defined as a pure-tone average (PTA) of thresholds across 0.5-1-2 kHz ＞ 25 dB; HFHI defined as a PTA across 3-4-6 kHz ＞ 25 dB in the worse ear. Survey-weighted logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) with adjustment for age, age-squared, sex, race/ethnicity, education, poverty-to-income ratio, body mass index, smoking status, exposures to occupational, recreational and firearm noises, and NHANES cycles. Results: There were no significant associations when perfluoroalkyl variables were fitted as a linear Clog-transformed) term. However, statistically significant associations of HFHI with PFNA (OR = 1.70, 95% CI: 1.13-2.56) and PFDA (OR = 1.75, 95% CI: 1.00-3.05) were observed when comparing participants with serum concentrations >90th vs. < 90th percentiles of PFNA (90th percentile = 1.8 ng/mL) and PFDA (90th percen-tile = 0.5 ng/mL), respectively, in adults aged 20-69 years. No significant associations were observed for other compounds in adults aged 20-69 years and for all compounds in adults ＞70 years. Conclusions: Our study does not provide strong evidence to support the ototoxicity of PFAS exposure. Non-linear threshold dose-response associations between serum concentrations of PFNA and PFDA and HFHI need further investigation.
机译：背景：诸如和多氟烷基物质（PFAS）广泛应用于消费品和工业产品，如非克里克炊具，防水服装，食品包装材料和消防泡沫。这些“永远化学品”被假设为影响神经兽性功能。然而，之前的研究没有探索PFA在视听上确定的听力障碍（HI）上的作用。目的：探讨全氟烷基物质的血清浓度与美国成年人低频HI（LFHI）和高频HI（HFHI）的关联。方法：我们评估了参与国家卫生和营养考试调查（Nhanes）2003-2004,2011-2012和2015-2016的20-69岁的成年人横断面关联; 449名成人距离Nhanes 2005-2006和2009-2010年龄> 70岁。使用固相萃取耦合到高性能液相色谱 - 涡轮增压的固相萃取测量血清全氟己烷磺酸（PFHXs），全氟辛酸（PFOA），全氟辛酸（PFOA），全氟乙酸（PFOA）和全氟二癸酸（PFDA）离子喷雾电离 - 串联质谱。将LFHI定义为纯度平均（PTA）横跨0.5-1-2 kHz> 25 dB的阈值; HFHI在更糟糕的耳朵中定义为跨越3-4-6 kHz> 25 dB的PTA。测量加权逻辑回归模型用于计算差距（或者）和95％的置信区间（CIs），调整年龄，年龄平方，性别，种族/种族，教育，贫困到收入比，体重指数，吸烟地位，暴露于职业，娱乐和枪支噪音，以及纳汉斯周期。结果：当全氟烷基变量装配为线性堵塞的）术语时，没有显着的关联。然而，当比较参与者的参与者> 90th与}时，观察到HFHI与PFNA（或= 1.70,95％CI：1.13-2.56）和PFDA（或= 1.75,95％CI：1.00-3.05）的统计学上显着的。分别在20-69岁的成人中分别在20-69岁的成人中分别为90百分位的PFNA（第90百分位数= 1.8 ng / ml）和PFDA（第90型Percen-Tile = 0.5ng / ml）。对于20-69岁的成人中的其他化合物并无观察到任何重大关联，并且在成人中的所有化合物> 70岁。结论：我们的研究没有提供强有力的证据来支持PFAS暴露的耳毒性。 PFNA和PFDA血清浓度与HFHI之间的非线性阈值剂量 - 反应关联需要进一步研究。

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  • 来源
    《Environmental research》 |2020年第8期|109686.1-109686.9|共9页
  • 作者

    Ning Ding; Sung Kyun Park;

  • 作者单位

    Department of Epidemiology University of Michigan School of Public Health Ann Arbor MI USA;

    Department of Epidemiology University of Michigan School of Public Health Ann Arbor MI USA Department of Environmental Health Sciences University of Michigan School of Public Health Ann Arbor MI USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Perfluoroalkyl substances; Hearing; NHANES;

    机译：全氟烷基物质;听力;纳汉斯;

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