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首页> 外文期刊>Environmental research >Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children
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Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children

机译：12岁日本儿童的产前和产前铅暴露与智力发展

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摘要

Background: Low-level lead exposure during childhood is associated with deficit in child IQ. However, the association between prenatal lead exposure and child IQ remains inconsistent. The objective of our study was to examine the association between prenatal/postnatal lead exposure and child IQ at the age of 12. Methods: We obtained data pertaining to cord-blood and child-blood lead levels and IQ for 286 children from a prospective birth cohort study (Tohoku Study of Child Development). IQ was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition. Simultaneously, the Boston Naming Test (BNT) was used to assess the children's language ability. Results: The median lead level in the cord blood was 0.8 μg/dL (5th-95th percentiles, 0.4-1.4 μg/dL), and that in the blood of 12-year-old children was 0.7 μg/dL (0.4-1.1 μg/dL). IQ and BNT scores were significantly lower in boys than in girls; therefore, multiple regression analysis was conducted separately for boys and girls. Among boys, IQ was associated with child-blood lead (B = -16.362, p = 0.033) but not cord-blood lead (B = -6.844, p = 0.309). When boys were divided into four groups according to the child-blood lead levels, there was a significant decreasing trend for IQ. The score with cues of the BNT was associated with both cord-blood (B = -5.893, p = 0.025) and child-blood (B = -7.108, p = 0.022) lead concentrations in boys. Among girls, there was no significant association of the outcomes with cord-blood or child-blood lead level.Conclusions: These findings suggest that postnatal lead exposure adversely affects the intellectual ability in boys. Furthermore, the language ability is sensitive to prenatal/postnatal lead exposure in boys.
机译：背景：儿童期间的低级铅暴露与儿童智商赤字相关。然而，产前铅曝光和儿童IQ之间的关联仍然不一致。我们研究的目的是审查产前/产后铅暴露和儿童IQ之间的关联。方法：从预期出生中获得了与脐带血和儿童血铅水平和IQ的数据有关的数据队列研究（对儿童发展的读书）。智商使用氟斯勒智商为儿童第四版进行评估。同时，波士顿命名试验（BNT）用于评估儿童的语言能力。结果：脐带血中的中值铅水平为0.8μg/ dL（5-95百分位数，0.4-1.4μg/ dl），12岁儿童的血液中为0.7μg/ dl（0.4-1.1 μg/ dl）。男孩智商和BNT得分明显低于女孩;因此，为男孩和女孩分开进行多元回归分析。在男孩中，IQ与儿童血液铅有关（B = -16.362，P = 0.033），但不是脐带血铅（B = -6.844，P = 0.309）。根据儿童血铅水平分为四组，智商的趋势显着下降。 BNT的SUES的分数与脐带血（B = -5.893，P = 0.025）和儿童（B = -7.108，P = 0.022）铅浓度有关。在女孩中，脐带血或儿童血铅水平没有显着的结果。结论：这些研究结果表明，产后铅暴露会对男孩的智力产生不利影响。此外，语言能力对男孩的产前/产前铅暴露敏感。

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  • 来源
    《Environmental research》 |2020年第10期|109844.1-109844.9|共9页
  • 作者

    Nozomi Tatsuta; Kunihiko Nakai; Yuichi Kasanuma; Miyuki Iwai-Shimada; Mineshi Sakamoto; Katsuyuki Murata; Hiroshi Satoh;

  • 作者单位

    Development and Environmental Medicine Tohoku University Graduate School of Medicine Sendai 980-8575 Japan;

    Development and Environmental Medicine Tohoku University Graduate School of Medicine Sendai 980-8575 Japan;

    Kesen-numa City Hospital Kesen-numa 988-0181 Japan Minami-Kesennuma Medical Clinic 988-0025 Japan;

    Centre for Health and Environmental Risk Research National Institute for Environmental Studies Tsukuba 305-8506 Japan;

    Development and Environmental Medicine Tohoku University Graduate School of Medicine Sendai 980-8575 Japan;

    Akita University Graduate School of Medicine Akita 010-8543 Japan;

    Tohoku University Graduate School of Medicine Sendai 980-8575 Japan;

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  • 正文语种 eng
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  • 关键词

    Child neurodevelopment; Intelligence quotient; Lead exposure; Methylmercury exposure;

    机译：儿童神经发育;情报商;铅接触;甲基汞暴露;

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