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首页> 外文期刊>Environmental research >Association of blood lead levels with preeclampsia: A cohort study in China
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Association of blood lead levels with preeclampsia: A cohort study in China

机译：血铅水平与预口普拉姆斯血统：中国的队列研究

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摘要

Background: Preeclampsia is the main cause of maternal and perinatal death, especially in developing countries. Multiple studies suggest that blood lead levels in pregnancy are a risk factor for preeclampsia, even with low levels of blood lead. But less knows the dose-effect relationship of preeclampsia in low blood lead levels. Objectives: This study aims to assess the association between blood lead levels and preeclampsia and to explore its dose-effect relationship between low blood lead levels and preeclampsia.Methods: The retrospective cohort study was consecutively conducted in a comprehensive tertiary hospital in Foshan city of Guangdong Province, China, from August 1, 2019, to November 30, 2019. Blood lead levels were measured in maternal whole blood in 12-27 (+6) weeks of pregnancy, using atomic absorption spectrometer. Preeclampsia diagnosis was ascertained from the electronic medical records system. The risk of preeclampsia was estimated by multivariable logical regression analysis, and a two-stage linear regression model was established to find out the dose-effect.Results: A total of 2174 people were included in this study, and 59 (2.7%) women developed preeclampsia. The dose-effect analysis revealed a non-linear association between blood lead levels and the risk of preeclampsia, with a cut-off point at 4.2 μg/dl. When blood lead levels were over 4.2 μg/dl, the risk of preeclampsia increased significantly with an increase in blood lead levels (OR = 2.05, 95%CI: 1.50, 2.81). In the multivariate regression models, per 1 μg/dl increment in blood lead levels was associated with 43% higher risk of developing preeclampsia (OR = 1.43,95%CI:1.17,1.74). Moreover, the association between blood lead levels and preeclampsia was stable in different subgroups.Conclusions: Low levels of lead exposure had a dose-effect relationship of preeclampsia, with a cut-off point at 4.2 μg/dl. Blood lead levels had a non-linear association with preeclampsia. When the blood lead levels were higher than 4.2 μg/dl, the risk of preeclampsia increases by 105% for every 1 μg/dl increase in blood lead levels.
机译：背景：Preclampsia是母亲和围产期死亡的主要原因，特别是在发展中国家。多项研究表明，妊娠期血液铅水平甚至是血铅水平低的危险因素。但较少了解预胰抗在低血铅水平中的剂量效应关系。目的：本研究旨在评估血铅水平和先兆子痫之间的关联，并探讨其低血铅水平与前普兰普斯的剂量效应关系。方法：回顾性队列在广东佛山市全综合院院进行了综合作用省，中国，2019年8月1日至2019年11月30日起。使用原子吸收光谱仪在怀孕12-27周（+6）周的母体全血中测量血铅水平。从电子医疗记录系统确定了预坦克塞症诊断。通过多变量逻辑回归分析估计了预先普拉姆的风险，建立了两级线性回归模型，以找出剂量效应。结果：本研究共有2174人，59名（2.7％）妇女开发出的预先普拉姆斯。剂量效应分析显示出血铅水平与预液位血症的风险之间的非线性关联，截止点为4.2μg/ dL。当血液铅水平超过4.2μg/ dl时，预口度的风险显着增加，血铅水平增加（或= 2.05,95％CI：1.50,2.81）。在多元回归模型中，血铅水平的每1μg/ dl增量与开发预液位胰岛的风险增加43％（或= 1.43,95％CI：1.17,1.74）。此外，血铅水平与预胰抗之间的关联在不同的亚组中稳定。结论：低水平的铅暴露具有预坦克敏的剂量效应关系，截止点为4.2μg/ dl。血铅水平具有与预坦克敏的非线性关联。当血液铅水平高于4.2μg/ dl时，预坦克西氏症的风险每1μg/ dl增加105％，血铅水平增加。

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  • 来源
    《Environmental research》 |2021年第4期|110822.1-110822.8|共8页
  • 作者

    Su Zhen Wu; Huan Ying Xu; Ying Chen; Yu Chen; Qiao Ling Zhu; Min Hua Tan; Miao Miao Zhang;

  • 作者单位

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

    Foshan Clinical Medical School of Guangzhou University of Chinese Medicine Chancheng District Foshan Guangdong province China;

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

    TCM Gynecology Department Foshan Chancheng Central Hospital Chancheng District Foshan Guangdong province China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Blood lead levels; Preeclampsia; Risk factors; Cohort study; Dose-effect relationship;

    机译：血铅水平;Preclampsia;风险因素;队列研究;剂量效应关系;
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