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Cause-specific stillbirth and exposure to chemical constituents and sources of fine particulate matter

机译：特定原因的死产并暴露于化学成分和细颗粒物来源

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摘要

The stillbirth rate in the United States is relatively high, but limited evidence is available linking stillbirth with fine particulate matter (PM_(2.5)), its chemical constituents and sources. In this study, we explored associations between cause-specific stillbirth and prenatal exposures to those pollutants with using live birth and stillbirth records from eight California locations during 2002-2009. ICD-10 codes were used to identify cause of stillbirth from stillbirth records. PM_(2.5) total mass and chemical constituents were collected from ambient monitors and PM_(2.5) sources were quantified using Positive Matrix Factorization. Conditional logistic regression was applied using a nested case-control study design (N = 32,262). We found that different causes of stillbirth were associated with different PM_(2.5) sources and/or chemical constituents. For stillbirths due to fetal growth, the odds ratio (OR) per interquartile range increase in gestational age-adjusted exposure to PM_(2.5) total mass was 1.23 (95% confidence interval (CI): 1.06, 1.44). Similar associations were found with resuspended soil (OR = 1.25, 95% CI: 1.10, 1.42), and secondary ammonium sulfate (0R = 1.45, 95% CI: 1.18, 1.78). No associations were found between any pollutants and stillbirths caused by maternal complications. This study highlighted the importance of investigating cause-specific stillbirth and the differential toxicity levels of specific PM_(2.5) sources and chemical constituents.
机译：美国的死胎率相对较高，但是将死胎与细颗粒物（PM_（2.5）），其化学成分和来源联系起来的证据有限。在这项研究中，我们使用2002年至2009年期间加利福尼亚州八个地点的活产和死产记录，探究了特定原因死产和产前暴露于这些污染物的关联。 ICD-10代码用于从死胎记录中识别死胎的原因。从环境监测仪中收集PM_（2.5）的总质量和化学成分，并使用正矩阵分解对PM_（2.5）的来源进行定量。使用嵌套病例对照研究设计（N = 32,262）应用条件逻辑回归。我们发现死胎的不同原因与不同的PM_（2.5）来源和/或化学成分有关。对于因胎儿生长而导致的死产，经胎龄校正后的PM_（2.5）总质量暴露量的每个四分位数范围的比值比（OR）为1.23（95％置信区间（CI）：1.06、1.44）。在重悬的土壤（OR = 1.25，95％CI：1.10，1.42）和仲硫酸铵（0R = 1.45，95％CI：1.18，1.78）上也发现了类似的关联。没有发现任何由孕妇并发症引起的污染物和死产之间的联系。这项研究强调了调查特定原因死胎以及特定PM_（2.5）来源和化学成分的不同毒性水平的重要性。

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  • 来源
    《Environmental research》 |2018年第1期|358-364|共7页
  • 作者

    Keita Ebisu; Brian Malig; Sina Hasheminassab; Constantinos Sioutas; Rupa Basu;

  • 作者单位

    Office of Environmental Health Hazard Assessment, California EPA, 1515 Clay Street, 16th floor, Oakland, CA 94612, USA;

    Office of Environmental Health Hazard Assessment, California EPA, 1515 Clay Street, 16th floor, Oakland, CA 94612, USA;

    Department of Civil and Environmental Engineering, University of Southern California, 3620 South Vermont Avenue, Los Angeles, CA 90089, USA;

    Department of Civil and Environmental Engineering, University of Southern California, 3620 South Vermont Avenue, Los Angeles, CA 90089, USA;

    Office of Environmental Health Hazard Assessment, California EPA, 1515 Clay Street, 16th floor, Oakland, CA 94612, USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Air pollution; Fine particulate matter (PM_(2.5)); PM_(2.5) Chemical constituents; Source apportionment; Stillbirth;

    机译：空气污染;细颗粒物（PM_（2.5））;PM_（2.5）化学成分;来源分配;死胎;

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