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首页> 外文期刊>Environmental research >Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans
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Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans

机译：墨西哥裔美国人的认知能力下降，死亡率和有机磷暴露

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摘要

Background: Cognitive impairment is a major health concern among older Mexican Americans, associated with significant morbidity and mortality, and may be influenced by environmental exposures. Objectives: To investigate whether agricultural based ambient organophosphorus COP) exposure influences 1) the rate of cognitive decline and mortality and 2) whether these associations are mediated through metabolic or inflammatory biomarkers. Methods: In a subset of older Mexican Americans from the Sacramento Area Latino Study on Aging (n = 430), who completed modified mini-mental state exams (3MSE) up to 7 times (1998-2007), we examined the relationship between estimated ambient OP exposures and cognitive decline (linear repeated measures model) and time to dementia or being cognitively impaired but not demented (CIND) and time to mortality (cox proportional hazards model). We then explored metabolic and inflammatory biomarkers as potential mediators of these relationships (additive hazards mediation). OP exposures at residential addresses were estimated with a geographic information system (GIS) based exposure assessment tool. Results: Participants with high OP exposure in the five years prior to baseline experienced faster cognitive decline (β = 0.038, p = 0.02) and higher mortality over follow-up (HR = 1.91, 95% CI = 1.12, 3.26). The direct effect of OP exposure was estimated at 241 (95% CI = 27-455) additional deaths per 100,000 person-years, and the proportion mediated through the metabolic hormone adiponectin was estimated to be 4% 1.5-19.2). No other biomarkers were associated with OP exposure. Conclusions: Our study provides support for the involvement of OP pesticides in cognitive decline and mortality among older Mexican Americans, possibly through biologic pathways involving adiponectin.
机译：背景：认知障碍是墨西哥老年人中的主要健康问题，与高发病率和死亡率相关，并且可能受到环境暴露的影响。目的：调查农业环境有机磷（COP）暴露是否影响1）认知能力下降和死亡率以及2）这些关联是否通过代谢或炎性生物标志物介导。方法：在萨克拉曼多地区拉丁裔衰老研究中的一部分较老的墨西哥裔美国人（n = 430）中，他们完成了多达7次（1998-2007）的修改过的迷你心理状态考试（3MSE），我们检查了估计值之间的关系。周围OP暴露和认知下降（线性重复测量模型）和痴呆或认知障碍但未痴呆的时间（CIND）和死亡时间（cox比例风险模型）。然后，我们探讨了代谢和炎症生物标志物作为这些关系的潜在介质（附加危害介质）。使用基于地理信息系统（GIS）的暴露评估工具估算居民地址的OP暴露。结果：在基线之前的五年中，高OP暴露的参与者在随访中出现了更快的认知下降（β= 0.038，p = 0.02）和更高的死亡率（HR = 1.91，95％CI = 1.12，3.26）。据估计，OP暴露的直接影响是每100,000人年新增241人（95％CI = 27-455）死亡，并且通过代谢激素脂连蛋白介导的比例估计为4％1.5-19.2）。没有其他生物标志物与OP暴露相关。结论：我们的研究提供了支持OP农药参与老年墨西哥裔美国人认知能力下降和死亡率的可能的途径，可能是通过涉及脂连蛋白的生物途径参与的。

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  • 来源
    《Environmental research》 |2018年第1期|132-139|共8页
  • 作者

    Kimberly C. Paul; Chenxiao Ling; Anne Lee; Tu My To; Myles Cockburn; Mary Haan; Beate Ritz;

  • 作者单位

    Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA;

    Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA;

    Department of Epidemiology & Biostanstics, UCSF, San Francisco, CA, USA;

    Department of Epidemiology & Biostanstics, UCSF, San Francisco, CA, USA;

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA;

    Department of Epidemiology & Biostanstics, UCSF, San Francisco, CA, USA;

    Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA,Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA;

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  • 正文语种 eng
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  • 关键词

    Organophosphates; Cognitive decline; Mortality; Mediation; Adiponectin; Mexican Americans;

    机译：有机磷酸盐;认知能力下降;死亡;调解;脂联素墨西哥裔美国人;

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