• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms
【24h】

Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms

机译：环境化学物和乳腺癌：以生物学机制为基础的流行病学文献的最新综述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Backgroun± Many common environmental chemicals are mammary gland carcinogens in animal studies, activate relevant hormonal pathways, or enhance mammary gland susceptibility to carcinogenesis. Breast cancer's long latency and multifactorial etiology make evaluation of these chemicals in humans challenging. Objective: For chemicals previously identified as mammary gland toxicants, we evaluated epidemiologic studies published since our 2007 review. We assessed whether study designs captured relevant exposures and disease features suggested by toxicological and biological evidence of genotoxicity, endocrine disruption, tumor promotion, or disruption of mammary gland development. Methods: We systematically searched the PubMed database for articles with breast cancer outcomes published in 2006-2016 using terms for 134 environmental chemicals, sources, or biomarkers of exposure. We critically reviewed the articles. Results: We identified 158 articles. Consistent with experimental evidence, a few key studies suggested higher risk for exposures during breast development to dichlorodiphenyltrichloroethane (DDT), dioxins, perfluorooctane-sulfonamide (PFOSA), and air pollution (risk estimates ranged from 2.14 to 5.0), and for occupational exposure to solvents and other mammary carcinogens, such as gasoline components (risk estimates ranged from 1.42 to 3.31). Notably, one 50-year cohort study captured exposure to DDT during several critical windows for breast development (in utero, adolescence, pregnancy) and when this chemical was still in use. Most other studies did not assess exposure during a biologically relevant window or specify the timing of exposure. Few studies considered genetic variation, but the Long Island Breast Cancer Study Project reported higher breast cancer risk for polycyclic aromatic hydrocarbons (PAHs) in women with certain genetic variations, especially in DNA repair genes. Conclusions: New studies that targeted toxicologically relevant chemicals and captured biological hypotheses about genetic variants or windows of breast susceptibility added to evidence of links between environmental chemicals and breast cancer. However, many biologically relevant chemicals, including current-use consumer product chemicals, have not been adequately studied in humans. Studies are challenged to reconstruct exposures that occurred decades before diagnosis or access biological samples stored that long. Other problems include measuring rapidly metabolized chemicals and evaluating exposure to mixtures.
机译：背景技术在动物研究中，许多常见的环境化学物质是乳腺致癌物，可激活相关的激素途径，或增强乳腺对致癌作用的敏感性。乳腺癌的潜伏期长和病因多，使对人体中这些化学物质的评估具有挑战性。目的：对于以前被确定为乳腺有毒物质的化学药品，我们评估了自2007年回顾以来发表的流行病学研究。我们评估了研究设计是否捕获了遗传毒性，内分泌破坏，肿瘤促进或乳腺发育破坏的毒理学和生物学证据所暗示的相关暴露和疾病特征。方法：我们使用134种环境化学物质，暴露来源或生物标志物的术语，系统性地搜索了2006-2016年发表的具有乳腺癌结局的文章的PubMed数据库。我们严格审查了这些文章。结果：我们确定了158篇文章。与实验证据一致，一些关键研究表明，乳房发育期间接触二氯二苯基三氯乙烷（DDT），二恶英，全氟辛烷磺酰胺（PFOSA）和空气污染（风险估计范围为2.14至5.0）和职业性暴露于较高的风险较高。溶剂和其他乳腺癌致癌物，例如汽油成分（风险估计范围为1.42至3.31）。值得注意的是，一项为期50年的队列研究捕获了在乳腺发育的几个关键窗口（子宫内，青春期，怀孕期间）和仍在使用该化学品的过程中，DDT的暴露。大多数其他研究未在生物学相关窗口内评估暴露或指定暴露时间。很少有研究考虑遗传变异，但是长岛乳腺癌研究项目报告说，具有某些遗传变异的女性，尤其是DNA修复基因中的女性，患多环芳烃（PAHs）的乳腺癌风险更高。结论：针对毒理学相关化学物质并捕获有关乳癌易感性遗传变异或窗口的生物学假设的新研究为环境化学物质与乳腺癌之间的联系提供了证据。然而，许多与生物有关的化学物质，包括当前使用的消费品化学物质，尚未在人体中得到充分研究。研究人员面临挑战，以重建在诊断之前数十年发生的暴露或获取如此长时间存储的生物样本。其他问题包括测量快速代谢的化学物质和评估混合物的暴露程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号