Abstract Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles
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Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles

机译：营养因子和养分管理对木豆叶中纯化的卡里甙的保肝功效的影响：肝炎诱导的细胞器中UGT1A1活性的评估

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AbstractCarlinoside is a unique compound well-known for its excellent curative potential in hepatitis. There is a substantial research gap regarding the medicinal use of carlinoside, as its concentrations are greatly variable (depending on locality). We cultivatedCajanus cajanusing vermicompost as a major organic amendment at two locations (Sonitpur and Birbhum) with different soil types, but identical climate conditions. Sonitpur soils were richer in soil organic C (SOC), enzyme activation, and N/P content than Birbhum. However, vermi-treatment improved many soil properties (bulk density, water retention, pH, N/P/K, and enzyme activity) to narrow the locational gap in soil quality by 15–28%. We also recorded a many-fold increment in SOC storage capacities in both locations, which was significantly correlated with carlinoside, total phenol, and flavonoid contents inCajanusleaves. This significantly up-regulated the carlinoside induced expression of the bilirubin-solubilizing UGT1A1enzyme in HepG2 cell and rat liver. Leaf extracts of vermicompost-aided plants could cure hepatitis in affected rat livers and in the HepG2 cell line. Accordingly, vermi-treatment is an effective route for the growth ofCajanusas a cash crop for biomedical applications and can produce a concurrent improvement in soil quality.Highlights•Soil organic C primarily induces carlinoside biosynthesis inCajanus cajan.•Vermicompost elevates the medicinal value ofCajanus cajanagainst hepatitis.•Vermi-treatedCajanusyield carlinoside stably irrespective of growing location.•Vermi-treated leaf extracts expedited bilirubin solubilization in rat liver.
机译： 摘要 Carlinoside是一种独特的化合物，以其在肝炎中极好的治疗潜力而闻名。由于其浓度差异很大（取决于地区），因此在药用方面存在很大的研究空白。我们在两个不同土壤类型但气候条件相同的地方（Sonitpur和Birbhum）使用ver堆肥作为主要的有机改良剂，种植了 Cajanus cajan 。 Sonitpur土壤的土壤有机碳（SOC），酶活化和N / P含量均高于Birbhum。但是，蠕虫处理改善了许多土壤特性（堆积密度，保水性，pH，N / P / K和酶活性），使土壤质量的位置差距缩小了15％至28％。我们还记录了这两个位置的SOC储存容量的许多倍增长，这与 Cajanus 叶中的卡柳糖苷，总酚和类黄酮含量显着相关。这显着上调了在HepG2细胞和大鼠肝脏中卡那洛甙诱导的胆红素增溶性UGT1A1酶的表达。 mi杂植物的叶提取物可以治愈受影响的大鼠肝脏和HepG2细胞系中的肝炎。因此，蠕虫处理是 Cajanus 作为生物医学应用经济作物生长的有效途径，并且可以同时改善土壤质量。 突出显示 • 土壤有机碳主要在 Cajanus cajan 。 • Vermicompost提高了 Cajanus cajan 对抗肝炎的药用价值。 • 经Vermi处理的 Cajanus ，无论生长位置如何，都能稳定地产生卡林糖苷。 • Vermi-处理过的叶提取物可加速大鼠肝脏中的胆红素溶解。

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