Abstract A prospective cohort study of the association between bisphenol A exposure and the serum levels of liver enzymes in children
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A prospective cohort study of the association between bisphenol A exposure and the serum levels of liver enzymes in children

机译：儿童双酚A暴露与血清肝酶水平之间关联性的前瞻性队列研究

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摘要

AbstractBackgroundBisphenol A (BPA) is an endocrine disrupter that acts in an estrogen-like manner. Few studies have investigated the association between urinary BPA concentrations and adverse liver function. Additionally, most studies were cross-sectional in nature and included only adults.ObjectivesWe evaluated BPA exposure levels and prospectively explored the association between BPA exposure and liver function in children.MethodsData were retrieved from the ongoing prospective Ewha Birth and Growth Cohort Study. Urinary BPA concentrations were measured in 164 children at 3–5 and 7–9 years of age. At each visit, fasting blood and urine samples were collected, and questionnaires were completed. The associations between the BPA concentrations at these ages and the serum levels of liver enzymes measured at 10–13 years of age were analyzed (n = 113). Multiple regression analysis was performed with adjustment for covariates. We also explored whether the BPA level exhibited dose-response relationships with liver enzyme levels.ResultsThe median urinary BPA concentrations were 0.76μg/g creatinine at 3–5 years and 0.61μg/g creatinine at 7–9 years of age. The urinary BPA concentrations at the two ages were correlated significantly (r= 0.23,p< 0.01). The urinary BPA concentrations at 7–9 years, but not that at 3–5 years, was associated significantly with the serum levels of liver enzymes at 10–13 years of age (p< 0.05). Those in the top tertile of urinary BPA concentration had higher levels of liver enzymes than did others. After adjustment for covariates, dose-response relationships of the BPA level with liver enzyme levels were evident at 7–9 years, but not at 3–5 years. Notably, the effect size was larger and the dose-response relationships were more evident in boys than in girls.ConclusionsExposure of children to even low doses of BPA may adversely affect later liver function.Highlights•Exposure of children to even low doses of BPA may adversely affect later liver function.•The adverse effects were more marked in boys than in girls.•Repeated-measures analysis showed that the BPA level at 3–5 years was higher than that at 7–9 years.
机译： 摘要 背景 双酚A（BPA）是一种内分泌干扰物以类似雌激素的方式起作用。很少有研究调查尿液中BPA浓度与不良肝功能之间的关系。此外，大多数研究本质上都是横断面的，仅包括成人。 目标 我们评估了BPA暴露水平，并前瞻性地探讨了BPA暴露与儿童的肝功能。 方法 数据是从正在进行的前瞻性梨花生育与生长队列研究中检索到的。在164位3-5岁和7-9岁的儿童中测量了尿液中BPA的浓度。每次访视时，均采集空腹血液和尿液样本，并填写问卷。分析了这些年龄的BPA浓度与10-13岁时测得的肝酶血清水平之间的关联（n = 113）。进行多元回归分析并调整协变量。我们还探讨了BPA水平是否与肝酶水平表现出剂量反应关系。 结果 尿液中BPA的中位数为0.76 3-5岁时的肌酐微克/克，7-9岁时的肌酐微克/克0.61微克/克。两个年龄段的尿液BPA浓度显着相关（ r = 0.23， p <0.01）。 7-13岁时尿中BPA的浓度与3-13岁时尿中的BPA浓度无关，与10-13岁时的肝酶血清水平显着相关（ p < 0.05）。尿液中BPA浓度最高的人群中的肝酶水平高于其他人群。调整协变量后，BPA水平与肝酶水平的剂量-反应关系在7-9年时很明显，而在3-5年时没有。值得注意的是，男孩比女孩更大的效应量并且剂量-反应关系更明显。 结论 接触儿童服用低剂量的BPA可能会对以后的肝功能产生不利影响。 突出显示 • 使儿童暴露于低剂量的BPA可能会对以后的肝功能产生不利影响。 • < ce：para id =“ p0010” view =“ all”>与男孩相比，男孩的不良反应更为明显。 • 重复措施分析显示，3-5年的BPA水平高于7-年的BPA水平9年。

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  • 来源
    《Environmental research》 |2018年第2期|195-201|共7页
  • 作者

    Seonhwa Lee; Hye Ah Lee; Bomi Park; Hyejin Han; Bo Hyun Park; Se Young Oh; Young Sun Hong; Eun Hee Ha; Hyesook Park;

  • 作者单位

    Department of Preventive Medicine, School of Medicine, Ewha Womans University;

    Clinical Trial Center, Mokdong Hospital, Ewha Womans University;

    Department of Preventive Medicine, School of Medicine, Ewha Womans University;

    Department of Preventive Medicine, School of Medicine, Ewha Womans University;

    Department of Preventive Medicine, School of Medicine, Ewha Womans University;

    Department of Food & Nutrition, Research Center for Human Ecology, College of Human Ecology, Kyung Hee University;

    Department of Internal Medicine, School of Medicine, Ewha Womans University;

    Department of Occupational and Environmental Medicine, School of Medicine, Ewha Womans University;

    Department of Preventive Medicine, School of Medicine, Ewha Womans University;

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  • 正文语种 eng
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  • 关键词

    Alanine aminotransferase; Aspartate aminotransferase; Bisphenol A; Children; Cohort study; Gamma-glutamyl transferase;

    机译：丙氨酸氨基转移酶;天冬氨酸氨基转移酶;双酚A;儿童;队列研究;γ-谷氨酰转移酶;

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