Abstract The association between exposure to air pollutants including PM_(10), PM_(2.5), ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration and the relative risk of developing STEMI: A case-crossover design
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首页> 外文期刊>Environmental research >The association between exposure to air pollutants including PM_(10), PM_(2.5), ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration and the relative risk of developing STEMI: A case-crossover design
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The association between exposure to air pollutants including PM_(10), PM_(2.5), ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration and the relative risk of developing STEMI: A case-crossover design

机译：暴露于包括PM_（10），PM_（2.5），臭氧，一氧化碳，二氧化硫和二氧化氮浓度的空气污染物与发展STEMI的相对风险之间的关联：案例交叉设计

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AbstractBackgroundUnfavorable associations between air pollution and myocardial infarction are broadly investigated in recent studies and some of them revealed considerable associations; however, controversies exists between these investigations with regard to culprit components of air pollution and significance of correlation between myocardial infarction risk and air pollution.MethodsThe association between exposure to PM10, PM2.5, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration of background air that residents of Tehran, the capital city of Iran, which is ranked as the most air polluted city of Iran and the relative risk of developing ST-elevation myocardial infarction (STEMI) were investigated by a case-crossover design. Our study included 208 patients admitted with a diagnosis of STEMI and undergone primary percutaneous intervention. Air pollutant concentration was averaged in 24-h windows preceding the time of onset of myocardial infarction for the case period. Besides, the mean level of each element of air pollution of the corresponding time in one week, two weeks and three weeks before onset of myocardial infarction, was averaged separately for each day as one control periods. Thus, 624 control periods were included in our investigation such that. Each patient is matched and compared with him/herself.ResultsThe mean level of PM10in case periods (61.47µg/m3) was significantly higher than its level in control periods (57.86µg/m3) (P-value = 0.019, 95% CI: 1.002–1.018, RR = 1.010). Also, the mean level of PM2.5in case periods (95.40µg/m3) was significantly higher than that in control days (90.88µg/m3) (P-value = 0.044, 95% CI: 1.001–1.011, RR = 1.006). The level of other components including NO2, SO2, CO and O3showed no significant differences between case and control periods. A 10µg/m3increase in PM10and PM2.5would result in 10.10% and 10.06% increase in STEMI event, respectively. Furthermore, the results of sub-group analysis showed that older patients (equal or more than 60 year-old), diabetic patients, non-hypertensive ones and patients with more than one diseased vessel may be more vulnerable to the harmful effect of particular matters including PM10and PM2.5on development of STEMI.ConclusionAir pollution is a worldwide pandemic with great potential to cause terrible events especially cardiovascular ones. PM2.5and PM10are amongst ambient air pollutant with a high risk of developing STEMI. Thus, more restrictive legislations should be applied to define a safe level of indoor and outdoor air pollutant production.Highlights•A 10µg/m3increase in PM10and PM2.5result in 10% increase in STEMI event.•Older patients, diabetic patients, and non-hypertensive ones may be more vulnerable to the harmful effect of particular matters.•PM2.5and PM10are among ambient air pollutant with a highrisk of developing STEMI.
机译： 摘要 背景 空气污染与心肌梗塞之间的不利联系是在最近的研究中进行了广泛的调查，其中一些揭示了相当的关联性；然而，这些研究之间存在着关于空气污染的罪魁祸首以及心肌梗塞风险与空气污染之间相关性的意义的争议。 方法 暴露于PM 10 ，PM 2.5 ，臭氧，伊朗首都德黑兰的居民的背景空气中的一氧化碳，二氧化硫和二氧化氮浓度被评为伊朗空气污染最严重的城市，而发展为ST抬高型心肌梗塞（STEMI）的相对风险为通过案例交叉设计进行调查。我们的研究包括208例确诊为STEMI并接受了初次经皮介入治疗的患者。在此期间，在心肌梗塞发作之前的24小时内，空气污染物的浓度取平均值。此外，将心肌梗塞发作前一周，两周和三周的相应时间的空气污染各要素的平均水平每天作为一个对照期分别进行平均。因此，我们的调查包括了624个控制期。每个患者都被匹配并与他/她自己进行比较。 < ce：section-title id =“ sect0020”>结果 PM的平均水平 10 的情况下（61.47µg / m 3 ）显着高于对照时段的水平（57.86µg / m < ce：sup loc =“ post”> 3 ）（P值= 0.019，95％CI：1.002-1.018，RR = 1.010）。此外，在某些情况下，PM 2.5 的平均水平（95.40µg / m 3 ）明显高于对照组（90.88µg / m 3 ）（P值= 0.044，95％CI：1.001–1.011，RR = 1.006） 。其他组件的级别包括NO 2 ，SO 2 ，CO和O 3 显示，病例与对照期之间没有显着差异。 PM 10 和PM 3 增加post“> 2.5 将分别导致STEMI事件增加10.10％和10.06％。此外，亚组分析的结果表明，年龄较大的患者（等于或大于60岁），糖尿病患者，非高血压患者和血管多于一个的患者可能更容易受到特定物质的有害影响包括PM 10 和PM 2.5 有关STEMI的开发。 结论 空气污染是一种全球性的大流行病，极有可能引起可怕的事件，尤其是心血管事件。 PM 2.5 和PM 10 属于环境空气污染物，极有可能发展为STEMI。因此，应采用更严格的法规来定义室内和室外空气污染物产生的安全水平。 突出显示 • 10µg / m 3 增加PM 10 和PM 2.5 导致STEMI事件增加10％。 • 老年患者，糖尿病患者，而非高血压的人可能更容易受到特定物质的有害影响。 • PM 2.5 和PM 10 属于发展为STEMI的高风险环境空气污染物之中。

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  • 来源
    《Environmental research》 |2018年第2期|299-303|共5页
  • 作者

    Mohammad Ali Akbarzadeh; Isa Khaheshi; Amirsina Sharifi; Negin Yousefi; Mohammadreza Naderian; Mohammad Hasan Namazi; Morteza Safi; Hossein Vakili; Habibollah Saadat; Saeed Alipour Parsa; Negin Nickdoost;

  • 作者单位

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences,Cardiac Outcome Research and Education (CORE), Universal Scientific Education and Research Network (USERN);

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

    Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Air pollution; Myocardial infarction; ST elevation myocardial infarction; Particulate matter;

    机译：空气污染;心肌梗塞;ST抬高型心肌梗塞;颗粒物;

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