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首页> 外文期刊>Environmental research >Distribution and predictors of urinary concentrations of phthalate metabolites and phenols among pregnant women in the Healthy Start Study
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Distribution and predictors of urinary concentrations of phthalate metabolites and phenols among pregnant women in the Healthy Start Study

机译：健康开始研究中孕妇邻苯二甲酸酯代谢物和酚的尿素浓度分布和预测指标

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摘要

BackgroundPhthalates and phenols are suspected endocrine disrupting chemicals that may adversely impact fetal outcomes followingin uteroexposure. Understanding predictors of exposure to phthalates and phenols during the prenatal period is important.nMethodsWe measured urinary concentrations of 15 phthalate metabolites and 11 phenols in 446 pregnant women enrolled in the Healthy Start pre-birth cohort. Creatinine-adjusted geometric means (GM) for each urinary biomarker were compared across categories of potential sociodemographic and dietary predictors. To assess the independent relationship between each significant food group predictor and biomarker we used multivariable models, adjusted for sociodemographic predictors.nResultsThe phthalate metabolites with the highest concentrations were monoethyl phthalate (GM: 41.1µg/g creatinine) and monocarboxyisooctyl phthalate (GM: 20.5µg/g creatinine). Benzophenone-3 (GM: 124.6µg/g creatinine) and methyl paraben (GM: 119.9µg/g creatinine) were the phenols with the highest concentrations. Concentrations of the metabolites of di-n-butyl phthalate and di(2-ethylhexyl) phthalate were significantly higher in younger, unmarried or unemployed mothers, those who were overweight or obese, those with lower educational attainment, or those of minority race/ethnicity (p-values < 0.05). Metabolites of di-n-butyl phthalate concentrations were 18% lower in those who consumed milk ≥ 7 times per week (95% CI: 30–4%). Benzophenone-3 and triclosan concentrations were significantly higher in older, married, or employed mothers, those with normal body mass index, higher educational attainment, higher household income, or who were non-Hispanic white (p-values < 0.05). Benzophenone-3 concentrations were 62% higher in those who consumed seafood ≥ 5 times per month (95% CI: 16–127%).nConclusionsWe observed differences in urinary concentrations of phthalates and phenol biomarkers by sociodemographic predictors in an ethnically diverse cohort of pregnant women. These results and future analyses from this prospective cohort will help inform targeted interventions to reduce exposure to these potential endocrine disrupting chemicals during pregnancy.
机译：背景邻苯二甲酸酯和苯酚被怀疑是内分泌干扰化学物质，可能在子宫内暴露后对胎儿结局产生不利影响。了解产前暴露于邻苯二甲酸盐和苯酚的预测因素很重要。n方法我们测量了446名参加“健康开始”分娩队列的孕妇的尿中15种邻苯二甲酸盐代谢产物和11种苯酚的浓度。对每种尿液生物标志物的肌酐调整几何平均值（GM）在潜在的社会人口统计学和饮食预测因素类别之间进行了比较。为了评估每个重要食物组预测指标和生物标记之间的独立关系，我们使用了针对社会人口统计学预测指标进行调整的多变量模型。n结果邻苯二甲酸酯代谢物的浓度最高，分别为邻苯二甲酸单乙酯（GM：41.1µg / g肌酐）和邻苯二甲酸单羧基异辛酯（GM：20.5µg）。 / g肌酐）。苯甲酮3（GM：124.6µg / g肌酐）和对羟基苯甲酸甲酯（GM：119.9µg / g肌酐）是浓度最高的酚。在年轻，未婚或失业的母亲，超重或肥胖的母亲，受教育程度较低的妇女或少数种族/民族的母亲中，邻苯二甲酸二正丁酯和邻苯二甲酸二（2-乙基己基）酯的代谢产物浓度明显较高。 （p值<0.05）。每周食用牛奶≥7次的人群中邻苯二甲酸二正丁酯浓度的代谢物降低18％（95％CI：30–4％）。年龄较大，已婚或受雇的母亲，体重指数正常，受教育程度较高，家庭收入较高或非西班牙裔白人的母亲中，苯甲酮3和三氯生的浓度明显更高（p值<0.05）。每月食用海鲜≥5次的人中苯甲酮3的浓度高62％（95％CI：16–127％）。n结论我们观察了根据社会人口统计学预测因素在孕妇种族不同的人群中邻苯二甲酸盐和酚生物标志物的尿液浓度差异女人。这些结果和该前瞻性队列的未来分析将有助于提供有针对性的干预措施，以减少怀孕期间对这些潜在的内分泌干扰化学物质的暴露。

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  • 来源
    《Environmental research》 |2018年第4期|308-317|共10页
  • 作者

    Kristen J. Polinski; Dana Dabelea; Richard F. Hamman; John L. Adgate; Antonia M. Calafat; Xiaoyun Ye; Anne P. Starling;

  • 作者单位

    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus;

    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus;

    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus;

    Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention;

    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus;

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  • 正文语种 eng
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  • 关键词

    Phthalate metabolites; Phenols; Benzophenone-3; Triclosan; DBP; DEHP; Human biomonitoring; Pregnancy; Predictors;

    机译：邻苯二甲酸酯;苯酚;苯甲酮-3;三氯生;DBP;DEHP;人类生物监测;妊娠;预测因子;

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