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Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment

机译：接受生育治疗的夫妇中的尿邻苯二甲酸酯和邻苯二甲酸酯替代代谢产物和异前列腺素

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摘要

Background: Epidemiological data suggest associations between phthalate exposures to a variety of adverse reproductive outcomes including reduced sperm quality and reproductive success. While mechanisms of these associations are not fully elucidated, oxidative stress has been implicated as a potential mediator. We examined associations of urinary metabolites of phthalates and phthalate alternative plasticizers with oxidative stress among couples seeking fertility treatment. Methods: Seventeen urinary plasticizer metabolites and 15-F2t isoprostane, a biomarker of oxidative stress, were quantified in spot samples from 50 couples seeking fertility treatment who enrolled in the Sperm Environmental Epigenetics and Development Study during 2014-2015. Results: In multivariable analyses, percent change in isoprostane was positively associated with interquartile range increases for the oxidative metabolites of di-2-ethylhexyl phthalate, [mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP; 20.0%, p=0.02), mono-2-ethyl-5-oxohexyl phthalate (MEOHP; 24.1%, p=0.01), and mono-2-ethyl-5-carboxypentyl phthalate (MECPP; 24.1%, p=0.004)], mono-isobutyl phthalate (MiBP; 17.8%, p=0.02), mono-hydroxyisobutyl phthalate (MHiBP; 27.5%, p=0.003), and cyclohexane-l,2-dicarboxylic acid mono-hydroxy-isononyl ester (MHINCH; 32.3%, p=0.002). Stratification of participants by sex revealed that isoprostane was positively associated with MHiBP (41.4%, p=0.01) and monocarboxy-isononyl phthalate (MCNP; 26.0%, p=0.02) among females and MEOHP (35.8%, p=0.03), MiBP (29.2%, p=0.01), MHiBP (34.7%, p=0.007) and MHINCH (49.0%, p=0.002) among males. Conclusions: Our results suggest that exposure to phthalates and phthalate replacements are associated with higher levels of oxidative stress in a sex-specific manner. Additional studies are needed to replicate our findings and to examine the potential health implications of the use of phthalates and alternative phthalates in consumer end products.
机译：背景：流行病学数据表明，邻苯二甲酸酯暴露与各种不良生殖结果之间的关联，包括降低精子质量和生殖成功。尽管还没有完全阐明这些关联的机制，但已暗示氧化应激是潜在的介质。我们研究了寻求生育治疗的夫妇中邻苯二甲酸盐和邻苯二甲酸盐替代增塑剂的尿代谢产物与氧化应激的关系。方法：在2014-2015年参加“精子环境表观遗传学和发育研究”的50对寻求生育治疗的夫妇的现场样本中，对17种尿液增塑剂代谢产物和15-F2t异前列腺素（氧化应激的生物标志物）进行了定量。结果：在多变量分析中，邻苯二甲酸二-2-乙基己酯，邻苯二甲酸单-2-乙基-5-羟基己酯（MEHHP; 20.0％，p = 0.02）的氧化代谢产物，异前列腺素的变化百分比与四分位数间距的增加呈正相关。 ，邻苯二甲酸单-2-乙基-5-氧己基酯（MEOHP; 24.1％，p = 0.01）和邻苯二甲酸单-2-乙基-5-羧基戊基酯（MECPP; 24.1％，p = 0.004）]，邻苯二甲酸单异丁酯（ MiBP; 17.8％，p = 0.02），邻苯二甲酸单羟基异丁酯（MHiBP; 27.5％，p = 0.003）和环己烷-1,2-二羧酸单羟基异壬酸酯（MHINCH; 32.3％，p = 0.002） 。按性别对参与者进行分层显示，女性和MEOHP（35.8％，p = 0.03）中的异前列腺素与MHiBP（41.4％，p = 0.01）和邻苯二甲酸单羧基异壬酯（MCNP; 26.0％，p = 0.02）正相关。男性中（29.2％，p = 0.01），MHiBP（34.7％，p = 0.007）和MHINCH（49.0％，p = 0.002）。结论：我们的研究结果表明，暴露于邻苯二甲酸盐和邻苯二甲酸盐替代品与性别特定方式的氧化应激水平较高有关。需要进行其他研究来复制我们的发现，并研究在消费类最终产品中使用邻苯二甲酸盐和替代邻苯二甲酸盐对健康的潜在影响。

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  • 来源
    《Environmental research》 |2017年第2期|1-7|共7页
  • 作者

    Haotian Wu; Alexandra Olmstec; David E. Cantonwine; Shahin Shahsavari; Tayyab Rahil; Cynthia Sites; J. Richard Pilsner;

  • 作者单位

    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003, United States;

    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003, United States;

    Department of Obstetrics Gynecology and Reproductive Biology, Division of Maternal Fetal Medicine Brigham and Women's Hospital, 75 Francis Street,Boston, MA 02115, United States;

    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003, United States;

    Division of Reproductive Endocrinology and Infertility, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, United States;

    Division of Reproductive Endocrinology and Infertility, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, United States;

    Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003, United States;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Phthalates; Endocrine disrupters; EDC; Isoprostane; Oxidative stress;

    机译：邻苯二甲酸盐;内分泌干扰物;EDC;异前列腺素;氧化应激;

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