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首页> 外文期刊>Environmental research >Diverging temporal trends of human exposure to bisphenols and plastizisers, such as phthalates, caused by substitution of legacy EDCs?
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Diverging temporal trends of human exposure to bisphenols and plastizisers, such as phthalates, caused by substitution of legacy EDCs?

机译：由传统EDC的替代引起的人类接触双酚和增塑剂（如邻苯二甲酸酯）的时间变化趋势不同？

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Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides. The results showed downward trends of several phthalates which are in the process of being regulated and phased out. Concomitantly, an increasing trend was seen for a metabolite of the phthalate replacer Di-iso-nonylcyclohexane 1,2-dicarboxylate (DiNCH). Bisphenol A (BPA) showed a downward trend, whereas bisphenol F, identified as one of the substitutes for BPA, showed an increasing trend. The decreasing trend of triclosan is likely due to declining use within the EU. Temporal trend studies of urine samples make it possible to investigate human exposure to rapidly metabolised substances and study how measures taken to regulate and replace problematic chemicals affect human exposure.
机译：在2009年至2014年间从瑞典乌普萨拉的首次母亲的尿液样本中对邻苯二甲酸盐和酚类物质进行了调查。这些物质具有相当快的新陈代谢，并且主要分析了尿中的代谢产物。主要目的是研究减少某些邻苯二甲酸盐和双酚A（BPA）的生产和使用的措施是否导致人体暴露减少，并确定替代化学品的暴露是否增加。评估了7种邻苯二甲酸酯，邻苯二甲酸酯替代品，四种不同的双酚，三氯生，一种基于有机磷酸酯的阻燃剂以及两种农药的代谢产物（n = 13）的时间趋势。结果表明，几种邻苯二甲酸酯的含量呈下降趋势，这些邻苯二甲酸酯正在被管制和逐步淘汰。随之而来的是，邻苯二甲酸酯替代品Di-异壬基环己烷1,2-二羧酸酯（DiNCH）的代谢产物呈上升趋势。双酚A（BPA）呈下降趋势，而双酚F（被视为BPA的替代品之一）呈上升趋势。三氯生的下降趋势可能是由于欧盟内部的使用减少。尿液样本的时间趋势研究使得调查人类暴露于快速代谢物质的可能性以及研究为调节和替代有问题的化学物质而采取的措施如何影响人类暴露成为可能。

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  • 来源
    《Environmental research》 |2017年第2期|48-54|共7页
  • 作者

    Irina Gyllenhammar; Anders Glynn; Bo A.G. Joensson; Christian H. Lindh; Per Ola Darnerud; Kettil Svensson; Sanna Lignell;

  • 作者单位

    National Food Agency, P.O. Box 622, 751 26, Uppsala, Sweden;

    National Food Agency, P.O. Box 622, 751 26, Uppsala, Sweden;

    Division of Occupational and Environmental Medicine, Lund University, 221 85, Lund, Sweden;

    Division of Occupational and Environmental Medicine, Lund University, 221 85, Lund, Sweden;

    National Food Agency, P.O. Box 622, 751 26, Uppsala, Sweden;

    National Food Agency, P.O. Box 622, 751 26, Uppsala, Sweden;

    National Food Agency, P.O. Box 622, 751 26, Uppsala, Sweden;

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