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The impact of ambient air pollution on the human blood metabolome

机译：环境空气污染对人体血液代谢组的影响

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摘要

Abstract Background Biological perturbations caused by air pollution might be reflected in the compounds present in blood originating from air pollutants and endogenous metabolites influenced by air pollution (defined here as part of the blood metabolome). We aimed to assess the perturbation of the blood metabolome in response to short term exposure to air pollution. Methods We exposed 31 healthy volunteers to ambient air pollution for 5h. We measured exposure to particulate matter, particle number concentrations, absorbance, elemental/organic carbon, trace metals, secondary inorganic components, endotoxin content, gaseous pollutants, and particulate matter oxidative potential. We collected blood from the participants 2h before and 2 and 18h after exposure. We employed untargeted metabolite profiling to monitor 3873 metabolic features in 493 blood samples from these volunteers. We assessed lung function using spirometry and six acute phase proteins in peripheral blood. We assessed the association of the metabolic features with the measured air pollutants and with health markers that we previously observed to be associated with air pollution in this study. Results We observed 89 robust associations between air pollutants and metabolic features two hours after exposure and 118 robust associations 18h after exposure. Some of the metabolic features that were associated with air pollutants were also associated with acute health effects, especially changes in forced expiratory volume in 1s. We successfully identified tyrosine, guanosine, and hypoxanthine among the associated features. Bioinformatics approach Mummichog predicted enriched pathway activity in eight pathways, among which tyrosine metabolism. Conclusions This study demonstrates for the first time the application of untargeted metabolite profiling to assess the impact of air pollution on the blood metabolome. Highlights • We employed metabolite profiling in 493 blood samples from 31 volunteers. • Changes in the blood metabolome were associated to variation in air pollution levels. • Some of the metabolic features were also associated with acute health effects. • We identified tyrosine, guanosine, and hypoxanthine among the associated features. • Pathway activity was enriched in eight pathways, among which tyrosine metabolism.
机译： 摘要 背景 可能会反映出由空气污染引起的生物干扰血液中存在的化合物中的污染物来自受空气污染影响的空气污染物和内源性代谢物（此处定义为血液代谢组的一部分）。我们旨在评估对短期暴露于空气污染的血液代谢组的扰动。 方法 我们公开了31名健康志愿者接受了5 h的环境空气污染。我们测量了暴露于颗粒物，颗粒数浓度，吸光度，元素/有机碳，痕量金属，次要无机成分，内毒素含量，气态污染物和颗粒物氧化电位的程度。我们在参与者暴露前2 h以及暴露后2和18 h的参与者中收集血液。我们采用了无针对性的代谢物分析技术来监测这些志愿者的493个血液样本中的3873个代谢特征。我们使用肺活量测定法和外周血中的六种急性期蛋白评估了肺功能。在本研究中，我们评估了代谢特征与所测量的空气污染物以及我们先前观察到的与空气污染有关的健康标志的关联。 结果 我们在暴露后两小时观察到了空气污染物与代谢特征之间的89个强相关性，而暴露后18 h则有118个强相关性。与空气污染物有关的某些代谢特征也与急性健康影响有关，尤其是1 s中强迫呼气量的变化。我们成功地鉴定了酪氨酸，鸟苷和次黄嘌呤的相关特征。生物信息学方法Mummichog预测了八种途径中丰富的途径活性，其中包括酪氨酸代谢。 结论 此研究首次展示了应用非目标代谢物分析法评估空气污染对血液代谢组的影响。 突出显示 • 我们在31位志愿者的493个血液样本中采用了代谢物分析。 • 血液代谢组的变化与 • 某些代谢功能也与急性健康影响相关。 • 我们在相关特征中确定了酪氨酸，鸟苷和次黄嘌呤。 • 途径活性丰富于八种途径，其中酪氨酸代谢。

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  • 来源
    《Environmental research》 |2017年第7期|341-348|共8页
  • 作者

    J.J. Vlaanderen; N.A. Janssen; G. Hoek; P. Keski-Rahkonen; D.K. Barupal; F.R. Cassee; I. Gosens; M. Strak; M. Steenhof; Q. Lan; B. Brunekreef; A. Scalbert; R.C.H. Vermeulen;

  • 作者单位

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

    National Institute for Public Health and the Environment (RIVM);

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

    International Agency for Research on Cancer;

    International Agency for Research on Cancer;

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University,National Institute for Public Health and the Environment (RIVM);

    National Institute for Public Health and the Environment (RIVM);

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

    US National Cancer Institute;

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

    International Agency for Research on Cancer;

    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University;

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  • 正文语种 eng
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  • 关键词

    Metabolite profiling; Air pollution; Blood; Cardio-respiratory health effects; Particulate matter components;

    机译：代谢物分析;空气污染;血液;心脏呼吸健康影响;颗粒物成分;

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