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首页> 外文期刊>Environmental research >Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue from northern Tunisia: Current extent of contamination and contributions of socio-demographic characteristics and dietary habits
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Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue from northern Tunisia: Current extent of contamination and contributions of socio-demographic characteristics and dietary habits

机译：突尼斯北部人类脂肪组织中的有机氯农药和多氯联苯：目前的污染程度以及社会人口统计学特征和饮食习惯的贡献

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摘要

Abstract The aims of the present study were to investigate the current exposure levels of persistent organochlorine compounds (OCs) in adipose tissues intraoperatively collected from 40 patients over 20 years undergoing non-cancer-related surgery residing in Northern region of Tunisia (Bizerte), which constitutes an exemplary case, and examined association between levels of contamination and both socio-demographic characteristics and dietary habits. Concentration of hexachlorobenzene (HCB), hexachlorocyclohexane isomers (α-HCH, β-HCH, γ-HCH and δ-HCH), dichlorodiphenyltrichloroethane isomers (p,p′-DDT and o,p′-DDT) and metabolites (p,p′-DDE, o,p′-DDE, p,p′-DDD and o,p′-DDD) and 12 polychlorinated biphenyls (PCBs) congeners were measured using capillary gas chromatography with electron capture detector. Overall, residue levels of OCs followed the decreasing order of DDTs PCBs HCB HCHs. DDTs levels ranged from 74.49 to 1834.76ngg−1 lipid and contributing to more than 90% to the sum of organochlorine pesticides (OCPs). p,p′-DDE was the most abundant in all samples and the p,p′-DDT/p,p′-DDE ratio (range between 1.85% and 58.45%) suggesting recent and ongoing exposure to banned commercial DDT products. PCB concentrations varied from 29.27 to 322.58ngg−1 lipid and PCB-180, PCB-153 and PCB-138 were the dominant congeners accounting for 70% of total PCBs. We did not find significant correlations between OC exposure levels and sex, parity, habitat areas and smoking habits. In females, the adipose tissue concentrations of DDTs, HCB and PCB-118 were positively correlated with age. There was statistically significant relationship between body mass index (BMI) changes and the adipose tissue levels of HCB and HCHs. No association was found between OCPs levels and dietary factors. However, our study suggests that fish consumption may be an important contributor of PCBs adipose tissue content of PCBs in Tunisian people. The presented work is highly significant, being the first study pointing out the chronic exposure to OCs in Bizerte. Highlights • First study to report HCB, HCHs, DDTs and PCBs in adipose tissues from Tunisia. • The measurement levels showed a general pattern as DDTsPCBs HCBHCHs. • p,p′-DDE and PCB-180, PCB-153 and PCB-138 were the marker substances of OCPs and PCBs, respectively. • Strong associations between concentrations of OCPs and PCBs suggest Tunisian are exposed via similar routes. • Fish consumption is a major source of dietary exposure to PCBs.
机译： 摘要 本研究的目的是调查20年来接受非癌治疗的40名患者术中收集的脂肪组织中持久性有机氯化合物（OCs）的当前暴露水平。突尼斯北部地区（比塞大）的一例与之相关的手术是一个典型案例，研究了污染水平与社会人口统计学特征和饮食习惯之间的关联。六氯苯（HCB），六氯环己烷异构体（α-HCH，β-HCH，γ-HCH和δ-HCH），二氯二苯基三氯乙烷异构体（p，p'-DDT和o，p'-DDT）和代谢物（p，p使用带有电子捕获检测器的毛细管气相色谱法测量了'-DDE，o，p'-DDE，p，p'-DDD和o，p'-DDD）和12种多氯联苯（PCB）同类物。总体而言，OC的残留水平遵循DDT> PCBs> HCB> HCHs的降序排列。 DDT的水平范围从74.49到1834.76 ng g -1 脂质占有机氯农药（OCP）总量的90％以上。 p，p'-DDE在所有样品中含量最高，并且p，p'-DDT / p，p'-DDE比率（介于1.85％和58.45％之间）表明最近和持续接触禁用的商业DDT产品。 PCB浓度从29.27到322.58 ng g − 1 脂质PCB-180，PCB-153和PCB-138是主要的同类产品，占PCB总数的70％。我们没有发现OC暴露水平与性别，均等，栖息地面积和吸烟习惯之间存在显着相关性。在女性中，DDTs，HCB和PCB-118的脂肪组织浓度与年龄呈正相关。体重指数（BMI）变化与HCB和HCH的脂肪组织水平之间存在统计学上的显着关系。在OCP水平和饮食因素之间未发现关联。但是，我们的研究表明，鱼类消费可能是突尼斯人体内多氯联苯脂肪组织中多氯联苯含量的重要因素。提出的工作非常重要，这是第一个指出比塞大长期接触OC的研究。 突出显示 • 第一个报告突尼斯脂肪组织中六氯苯，六氯环己烷，滴滴涕和多氯联苯的研究。 • 测量级别显示了一种一般模式，即DDT> PCB > HCB>六氯环己烷。 • p，p'-DDE和PCB-180，PCB-153和PCB-138分别是OCP和PCB的标志物。 • OCPs和PCBs浓度之间的强烈关联表明突尼斯人通过相似的路径公开。 • 鱼的摄入是膳食中多氯联苯饮食的主要来源。 < / ce：abstract-sec>

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  • 来源
    《Environmental research》 |2017年第7期|635-643|共9页
  • 作者

    Amani Achour; Abdelkader Derouiche; Badreddine Barhoumi; Badreddine Kort; Driss Cherif; Sondes Bouabdallah; Mohsen Sakly; Khémais Ben Rhouma; Soufiane Touil; Mohamed Ridha Driss; Olfa Tebourbi;

  • 作者单位

    Laboratory of Integrated Physiology, Faculty of Science of Bizerte, University of Carthage Tunisia;

    Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage;

    Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage;

    Service of General Surgery, Regional Hospital of Menzel Bourguiba;

    Free Practice Surgeon;

    Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage;

    Laboratory of Integrated Physiology, Faculty of Science of Bizerte, University of Carthage Tunisia;

    Laboratory of Integrated Physiology, Faculty of Science of Bizerte, University of Carthage Tunisia;

    Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage;

    Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerte, University of Carthage;

    Laboratory of Integrated Physiology, Faculty of Science of Bizerte, University of Carthage Tunisia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Human adipose tissues; Organochlorine pesticides; Polychlorinated biphenyls; Socio-demographic characteristics; Dietary habits; Tunisia;

    机译：人体脂肪组织;有机氯农药;多氯联苯;社会人口学特征;饮食习惯;突尼斯;

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