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Ambient temperature and cardiovascular biomarkers in a repeated-measure study in healthy adults: A novel biomarker index approach

机译：健康成年人环境温度和心血管生物标志物的重复测量研究：一种新型生物标志物指数方法

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Abstract Background Associations of ambient temperature with cardiovascular morbidity and mortality have been well documented in numerous epidemiological studies, but the underlying pathways remain unclear. We investigated whether systemic inflammation, coagulation, systemic oxidative stress, antioxidant activity and endothelial function may be the mechanistic pathways associated with ambient temperature. Methods Forty study participants underwent repeated blood collections for 12 times in Beijing, China in 2010–2011. Ambient temperature and air pollution data were measured in central monitors close to student residences. We created five indices as the sum of weighted biomarker percentiles to represent the overall levels of 15 cardiovascular biomarkers in five pathways (systemic inflammation: hs-CRP, TNF-α and fibrinogen; coagulation: fibrinogen, PAI-1, tPA, vWF and sP-selectin; systemic oxidative stress: Ox-LDL and sCD36: antioxidant activity: EC-SOD and GPX1; and endothelial function: ET-1, E-selectin, ICAM-1 and VCAM-1). We used generalized mixed-effects models to estimate temperature effects controlling for air pollution and other covariates. Results There were significant decreasing trends in the adjusted means of biomarker indices over the lowest to the highest quartiles of daily temperatures before blood collection. A 10°C decrease at 2-d average daily temperature were associated with increases of 2.5% [95% confidence interval (CI): 0.7, 4.2], 1.6% (95% CI: 0.1, 3.1), 2.7% (95% CI: 0.5, 4.8), 5.5% (95% CI: 3.8, 7.3) and 2.0% (95% CI: 0.3, 3.8) in the indices for systemic inflammation, coagulation, systemic oxidative stress, antioxidant activity and endothelial function, respectively. In contrast, the associations between ambient temperature and individual biomarkers had substantial variation in magnitude and strength. Conclusions The altered cardiovascular biomarker profiles in healthy adults associated with ambient temperature changes may help explain the temperature-related cardiovascular morbidity and mortality. The biomarker index approach may serve as a novel tool to capture ambient temperature effects. Highlights • The mechanisms remain unclear for ambient temperature-related cardiovascular effects. • We created 5 weighted indices to represent 15 cardiovascular biomarkers in 5 pathways. • Decreasing temperature was associated with significant increases in these indices. • Individual biomarkers were diversely associated with ambient temperature. • The biomarker index approach may serve as a novel tool to capture temperature effects.
机译： 摘要 背景 环境温度与心血管疾病发病率和死亡率的关联已在许多流行病学研究，但基本途径仍不清楚。我们调查了全身性炎症，凝血，全身性氧化应激，抗氧化活性和内皮功能是否可能是与环境温度相关的机制。 方法 四十年代研究参与者于2010-2011年在中国北京进行了12次重复采血。在学生宿舍附近的中央监视器中测量了环境温度和空气污染数据。我们创建了五个指数作为加权生物标志物百分位数的总和，以代表五个途径（全身性炎症：hs-CRP，TNF-α和纤维蛋白原；凝血：纤维蛋白原，PAI-1，tPA，vWF和sP）中15种心血管生物标志物的总体水平-选择素；全身氧化应激：Ox-LDL和sCD36：抗氧化活性：EC-SOD和GPX1；内皮功能：ET-1，E-选择素，ICAM-1和VCAM-1。我们使用广义混合效应模型来估算控制空气污染和其他协变量的温度效应。 结果 调整后的血液采集前每天最低或最高四分位数的生物标志物指数。每天平均2 d的温度每降低10 °C，则温度升高2.5％[95％置信区间（CI）：0.7、4.2]，1.6％（95％CI ：系统性炎症，凝血指标的0.1％，3.1％，2.7％（95％CI：0.5、4.8），5.5％（95％CI：3.8、7.3）和2.0％（95％CI：0.3、3.8），全身氧化应激，抗氧化活性和内皮功能。相比之下，环境温度与单个生物标记之间的关联在强度和强度上存在很大差异。 结论 健康成年人与以下疾病相关的心血管生物标志物特征改变环境温度的变化可能有助于解释与温度有关的心血管疾病的发病率和死亡率。生物标志物索引方法可以用作捕获环境温度影响的新颖工具。 突出显示 • 对于与环境温度相关的心血管效应的机制仍不清楚。 • 我们创建了5个加权指数来代表5个中的15种心血管生物标记 • 温度降低与这些指数的显着增加有关。 • 各个生物标记物与环境温度的关系各不相同。 • 生物标记指数方法可能是捕捉温度效应的新颖工具。

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  • 来源
    《Environmental research》 |2017年第7期|231-238|共8页
  • 作者

    Shaowei Wu; Di Yang; Lu Pan; Jiao Shan; Hongyu Li; Hongying Wei; Bin Wang; Jing Huang; Andrea A. Baccarelli; Masayuki Shima; Furong Deng; Xinbiao Guo;

  • 作者单位

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Institute of Reproductive & Child Health, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University;

    Department of Public Health, Hyogo College of Medicine;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University;

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  • 正文语种 eng
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  • 关键词

    Cardiovascular health; Coagulation; Endothelial function; Inflammation; Oxidative stress; Temperature;

    机译：心血管健康;凝血;内皮功能;炎症;氧化应激;温度;

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