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Use of exhaled air as an improved biomonitoring method to assess perchloroethylene short-term exposure

机译：使用呼出空气作为评估全氯乙烯短期暴露的改进的生物监测方法

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Abstract This paper shows the use of exhaled air as a biomonitoring method to assess perchloroethylene (PERC) environmental and occupational exposure. A sensitive, fast, and solvent free analytical method was developed to determine PERC in ambient and exhaled air of individuals occupationally exposed. The developed method used cold fiber solid phase microextraction (CF-SPME) as the sampling technique, and a standard permeation method to simulation of air matrix. The analysis were conducted by gas chromatography coupled to mass spectrometry (GC/MS). The methods were validated and were found to be precise, linear and sensitive for environmental and biological monitoring. The developed methods were applied to twenty-seven sampling points spread across Belo Horizonte city, Brazil, twenty four dry cleaners, an electroplating industry, a research laboratory, and an automotive paint preparation shop. The results of ambient air analyses ranging from 14.0 to 3205.0µgm−3 with median concentration of 599.0µgm−3. Furthermore, sampling of exhaled air of individuals occupationally exposed presented results ranging from 6.0 to 2635.0µgm−3 with median concentration of 325.0µgm−3. The strong correlation observed between ambient and exhaled air (r =0.930) demonstrates that exhaled air is a suitable biomarker for evaluating occupational exposure to PERC. Highlights • Exhaled air as biomonitoring method to assess perchloroethylene (PERC) environmental and occupational exposure. • Strong correlation between PERC concentrations in exhaled and ambient air. • Twenty-seven samples collected in occupational environment. • Sensitive cold fiber solid phase microextraction (CF-SPME) method to sampling PERC. • Determination by chromatography/mass spectrometry (GC/MS) showing good precision and sensibility.
机译： 摘要 本文显示了呼出空气作为生物监测方法来评估全氯乙烯（PERC）环境和职业暴露的方法。开发了一种灵敏，快速且无溶剂的分析方法，可测定职业暴露人员的环境和呼出空气中的PERC。该方法采用冷纤维固相微萃取（CF-SPME）作为采样技术，并采用标准渗透法模拟空气基质。通过气相色谱-质谱联用（GC / MS）进行分析。这些方法已经过验证，被发现对于环境和生物监测而言是精确，线性和敏感的。所开发的方法被应用于分布在巴西贝洛哈里桑塔市的27个采样点，24个干洗店，电镀行业，研究实验室和汽车油漆制备车间。环境空气分析的结果范围为14.0到3205.0 µg m -3 的中位数浓度为599.0 µg m -3 。此外，对职业接触个人的呼气采样结果范围从6.0到2635.0 µg m −3 ，中位数浓度为325.0 µg m − 3 。观察到的环境空气与呼出空气之间的强相关性（r = 0.930）表明，呼出空气是评估职业性PERC暴露的合适生物标记。 突出显示 • 呼出空气作为生物监测方法，以评估全氯乙烯（PERC）的环境和职业暴露。 • < ce：para id =“ p0010” view =“ all”>呼出空气和环境空气中PERC浓度之间的相关性很强。 • 在职业环境中收集了27个样品。 • 敏感的冷纤维固相微萃取（CF-SPME ）进行PERC采样的方法。 • 色谱/质谱法（GC / MS）测定，显示出良好的精密度和敏感性。

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