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首页> 外文期刊>Environmental research >Analysis of human hair to assess exposure to organophosphate flame retardants: Influence of hair segments and gender differences
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Analysis of human hair to assess exposure to organophosphate flame retardants: Influence of hair segments and gender differences

机译：分析人的头发以评估其对有机磷酸酯阻燃剂的暴露：头发片段和性别差异的影响

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摘要

Hair is a promising, non-invasive, human biomonitoring matrix that can provide insight into retrospective and integral exposure to organic pollutants. In the present study, we measured the concentrations of organophosphate flame retardants (PFRs) in hair and serum samples from university students in Guangzhou, China, and compared the PFR concentrations in the female hair segments using paired distal (5～10 cm from the root) and proximal (0～5 cm from the root) samples. PFRs were not detected in the serum samples. All PFRs except tricresyl phosphate (TMPP) and tri-n-propyl phosphate (TPP) were detected in more than half of all hair samples. The concentrations of total PFRs varied from 10.1 to 604 ng/g, with a median of 148 ng/g. Tris(chloroisopropyl) phosphate (TCIPP) and tri(2-ethylexyl) phosphate (TEHP) were the predominant PFRs in hair. The concentrations of most PFRs in the distal segments were 1.5～8.6 times higher than those in the proximal segments of the hair (t-test, p ＜ 0.05), which may be due to the longer exposure time of the distal segments to external sources. The values of log (PFR concentrations-distal/PFR concentrations-proximal) were positively and significantly correlated with log K_(OA) of PFRs (p ＜ 0.05, r=0.68), indicating that PFRs with a higher log K_(OA) tend to accumulate in hair at a higher rate than PFRs with a lower log K_(OA). Using combined segments of female hair, significantly higher PFR concentrations were observed in female hair than in male hair. In contrast, female hair exhibited significantly lower PFR concentrations than male hair when using the same hair position for both genders (0-5 cm from the scalp). The controversial results regarding gender differences in PFRs in hair highlight the importance of segmental analysis when using hair as an indicator of human exposure to PFRs.
机译：头发是一种有前途的，非侵入性的人类生物监测矩阵，可以提供对有机污染物的回顾性和整体性暴露的见识。在本研究中，我们测量了来自中国广州大学生的头发和血清样本中有机磷酸酯阻燃剂（PFRs）的浓度，并使用配对的远端（距根部5〜10 cm）比较了女性头发中的PFR浓度。 ）和近端（距根部0〜5 cm）的样本。在血清样品中未检测到PFR。在超过一半的头发样本中检测到除磷酸三甲苯酯（TMPP）和磷酸三正丙酯（TPP）之外的所有PFR。总PFR的浓度从10.1至604 ng / g不等，中位数为148 ng / g。磷酸三（氯异丙基）酯（TCIPP）和磷酸三（2-乙基己基）酯（TEHP）是头发中的主要PFR。远端部分中大多数PFRs的浓度是头发近端部分中1.5-8.6倍（t检验，p ＜0.05），这可能是由于远端部分暴露在外部的时间更长。 log值（PFR浓度-远侧/ PFR浓度-近侧）与PFR的log K_（OA）呈正相关（p <0.05，r = 0.68），表明log K_（OA）较高的PFR倾向于比具有较低log K_（OA）的PFR在头发中积累的速率更高。使用女性头发的组合片段，观察到女性头发中的PFR浓度明显高于男性头发。相反，当男性和女性使用相同的头发位置（距头皮0-5厘米）时，女性头发的PFR浓度明显低于男性头发。关于头发中PFR性别差异的有争议的结果凸显了使用头发作为人类暴露于PFR的指标时，分段分析的重要性。

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  • 来源
    《Environmental research》 |2016年第7期|177-183|共7页
  • 作者

    Lin Qiao; Xiao-Bo Zheng; Jing Zheng; Wei-Xiang Lei; Hong-Fang Li; Mei-Huan Wang; Chun-Tao He; She-Jun Chen; Jian-Gang Yuan; Xiao-Jun Luo; Yun-Jiang Yu; Zhong-Yi Yang; Bi-Xian Mai;

  • 作者单位

    State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China ,Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China;

    College of Resources and Environment, South China Agricultural University, Guangzhou 510642, China ,State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

    Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China;

    Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China;

    Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong Province, China;

    Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China;

    State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

    State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

    State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

    State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

    Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China;

    State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

    State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Human hair; Serum; Organophosphate flame retardants; Segmental difference; Gender difference;

    机译：人的头发;血清;有机磷酸酯阻燃剂;分段差异;性别差异;

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