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首页> 外文期刊>Environmental research >Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort
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Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort

机译：以人群为基础的队列中低水平的铅，血压和高血压暴露

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摘要

Background: Environmental lead exposure is a possible causative factor for increased blood pressure and hypertension, but large studies at low-level exposure are scarce, and results inconsistent. Objective: We aimed to examine the effects of environmental exposure to lead in a large population-based sample. Methods: We assessed associations between blood lead and systolic/diastolic blood pressure and hypertension in 4452 individuals (46-67 years) living in Malmoe, Sweden, in 1991-1994. Blood pressure was measured using a mercury sphygmomanometer after 10 min supine rest. Hypertension was defined as high systolic (≥ 140 mmHg) or diastolic (≥ 90 mmHg) blood pressure and/or current use of anti-hypertensive medication. Blood lead was calculated from lead in erythrocytes and haematocrit. Multi-variable associations between blood lead and blood pressure or hypertension were assessed by linear and logistic regression. Two-thirds of the cohort was re-examined 16 years later. Results: At baseline, mean blood pressure was 141/87 mmHg, 16% used antihypertensive medication, 63% had hypertension, and mean blood lead was 28 μg/L. Blood lead in the fourth quartile was associated with significantly higher systolic and diastolic blood pressure (point estimates: 1-2 mmHg) and increased prevalence of hypertension (odds ratio: 1.3, 95% confidence interval: 1.1-1.5) versus the other quartiles after adjustment for sex, age, smoking, alcohol, waist circumference, and education. Associations were also significant with blood lead as a continuous variable. Blood lead at baseline, having a half-life of about one month, was not associated with antihypertensive treatment at the 16-year follow-up. Conclusions: Low-level lead exposure increases blood pressure and may increase the risk of hypertension.
机译：背景：环境中铅的暴露可能是导致血压升高和高血压的原因，但是缺乏大量有关低水平暴露的研究，结果不一致。目的：我们旨在检查在大量人群样本中暴露于铅对环境的影响。方法：我们评估了1991-1994年生活在瑞典马尔默市的4452个体（46-67岁）的血铅与收缩压/舒张压和高血压之间的关联。仰卧休息10分钟后，使用水银血压计测量血压。高血压被定义为收缩压高（≥140 mmHg）或舒张压高（≥90 mmHg）和/或当前使用降压药。根据红细胞和血细胞比容中的铅计算血铅。通过线性和逻辑回归评估血铅与血压或高血压之间的多变量关联。 16年后，对该队列的三分之二进行了重新检查。结果：基线时，平均血压为141/87 mmHg，使用降压药的占16％，患有高血压的占63％，平均血铅为28μg/ L。与四分位数后的其他四分位数相比，第四四分位数中的血铅与收缩压和舒张压明显升高（点估计值：1-2 mmHg）和高血压患病率升高（几率：1.3、95％置信区间：1.1-1.5）相关。调整性别，年龄，吸烟，酒精，腰围和教育程度。血铅作为连续变量的关联也很显着。在16年的随访中，基线的血铅半衰期约为1个月，与降压治疗无关。结论：低水平的铅暴露会增加血压，并可能增加患高血压的风险。

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  • 来源
    《Environmental research》 |2016年第8期|157-163|共7页
  • 作者

    Angela Gambelunghe; Gerd Sallsten; Yan Borne; Niklas Forsgard; Bo Hedblad; Peter Nilsson; Bjoern Fagerberg; Gunnar Engstroem; Lars Barregard;

  • 作者单位

    Department of Medicine, Section of Occupational Medicine and Toxicology, University of Perugia, Italy;

    Department of Occupational and Environmental Medicine, University of Gothenburg, Sweden;

    Cardiovascular Epidemiology, Department of Clinical Sciences in Malmoe, Lund University, and Skane University Hospital, Malmoe, Sweden;

    Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden;

    Cardiovascular Epidemiology, Department of Clinical Sciences in Malmoe, Lund University, and Skane University Hospital, Malmoe, Sweden;

    Department of Clinical Sciences in Malmoe, Lund University and Skane University Hospital, Sweden;

    Department of Molecular and Clinical Medicine, Wallenberg Laboratory for Cardiovascular and Metabolic Research, University of Gothenburg, and Sahlgrenska University Hospital, Sweden;

    Cardiovascular Epidemiology, Department of Clinical Sciences in Malmoe, Lund University, and Skane University Hospital, Malmoe, Sweden;

    Department of Occupational and Environmental Medicine, University of Gothenburg, P.B. 414, SE 405 30 Gothenburg, Sweden;

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  • 正文语种 eng
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  • 关键词

    Blood lead; Blood pressure; Hypertension; Cohort; Cadmium;

    机译：血铅血压;高血压;队列镉;

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