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首页> 外文期刊>Environmental research >Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population
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Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population

机译:食物摄入量过高导致邻苯二甲酸二(2-乙基己基)邻苯二甲酸酯(DEHP)暴露对台湾人群青春期前生长特征的影响

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摘要

On May 23, 2011, a major scandal involving the illegal use of phthalates as clouding agents in food products was reported. Specifically, di(2-ethylhexyl) phthalate (DEHP) was purposefully added to foods as a substitute emulsifier. The purpose of this study was to examine the effects of DEHP exposure on the growth characteristics of the child victims of this scandal. Eighty-eight victims, originating from northern, central, and southern Taiwan and ranging in age from 6.0 to 10.5 years, were invited to participate in this study during clinic visits. The participants underwent follow-up health examinations from August 2012 to February 2013. We collected information on each participant's history of exposure to tainted food products using a questionnaire, and we analyzed their urinary concentrations of DEHP metabolites using high-performance liquid chromatography/tandem mass spectrometry. These data were then used to estimate their daily DEHP intake (DI_(All)) during the scandal. We also measured physical development parameters (height, weight, and bone age) and hormone levels (thyroid, sex and growth hormones) to evaluate their overall growth characteristics. The average (SD) duration of DEHP intake from tainted nutrition supplements was 1.39 (1.01) years. The median DI_(All) values were 19.93 and 20.69 μg/kg bw/day for boys and girls, respectively. Among the enrolled children, the DI_(All) values of 46.9% of boys and 51.3% of girls exceeded the reference dose (RfD) of 20 μg/kg bw/day established by the US Environmental Protection Agency. Our results demonstrate that DI_(All) is negatively associated with the height percentile, weight percentile, bone age/chronological age, and insulin-like growth factor 1 (IGF-1) levels but not with IGF binding protein 3 (IGF-BP3) level, IGF-1/IGF-BP3, sex hormones, or thyroid hormone levels. The DEHP DI_(All) value exceeded the RfD at high rates among children of both genders. Our results suggest that high levels of DEHP exposure due to the consumption of tainted food products are negatively associated with body weight, height, bone age, and IGF-1 levels in children. The likelihood of delayed puberty among the affected children is therefore a reasonable concern, and further follow-up is required.
机译:2011年5月23日,据报道发生了一起重大丑闻,涉及在食品中非法使用邻苯二甲酸盐作为混浊剂。具体而言,有目的地将邻苯二甲酸二(2-乙基己基)酯(DEHP)作为替代乳化剂添加到食品中。这项研究的目的是检验DEHP暴露对该丑闻受害儿童生长特征的影响。来自台湾北部,中部和南部,年龄在6.0至10.5岁之间的88位受害者被邀请参加诊所访问期间的这项研究。参与者于2012年8月至2013年2月接受了后续健康检查。我们使用问卷调查收集了每个参与者接触受污染食品的历史信息,并使用高效液相色谱/串联质谱分析了他们的尿中DEHP代谢物浓度。光谱法。然后将这些数据用于估计丑闻期间的每日DEHP摄入量(DI_(All))。我们还测量了身体发育参数(身高,体重和骨龄)和激素水平(甲状腺,性激素和生长激素),以评估其总体生长特征。从受污染的营养补充剂中摄入DEHP的平均持续时间为1.39(1.01)年。男孩和女孩的DI_(All)中位值分别为19.93和20.69μg/ kg bw /天。在入组儿童中,男孩(46.9%)和女孩(51.3%)的DI_(全部)值超过了美国环境保护署规定的每日参考剂量(RfD)20μg/ kg bw /天。我们的结果表明,DI_(All)与身高百分比,体重百分比,骨骼年龄/年龄和胰岛素样生长因子1(IGF-1)水平呈负相关,但与IGF结合蛋白3(IGF-BP3)无负相关。水平,IGF-1 / IGF-BP3,性激素或甲状腺激素水平。男女儿童的DEHP DI_(All)值均超过RfD。我们的结果表明,由于食用受污染的食品而导致的DEHP暴露水平与儿童的体重,身高,骨龄和IGF-1水平呈负相关。因此,受影响的儿童中青春期延迟的可能性是一个合理的问题,因此需要进一步的随访。

著录项

  • 来源
    《Environmental research》 |2016年第8期|197-205|共9页
  • 作者单位

    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei, Taiwan;

    Department of Endocrinology & Metabolism, Cathay General Hospital, Taipei, Taiwan,School of Medicine, Fu Jen Catholic University, Taipei, Taiwan;

    School of Medicine, Fu Jen Catholic University, Taipei, Taiwan,Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan;

    National Environmental Health Research Center, National Health Research Institutes, Miaoli, Taiwan;

    Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan;

    Department of Laboratory Medicine and Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan,Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;

    Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan,Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan,Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan,Center of Environmental and Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan;

    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan;

    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan;

    Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan,Research Center of Environmental Trace Toxic Substance, National Cheng Kung University, Tainan, Taiwan;

    Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan,Institute of Population Health Sciences, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, ROC;

    Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei, Taiwan,Institute of Environmental and Occupational Health Sciences, No.155, Sec. 2, Linong Street, Taipei 112, Taiwan, ROC;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Di(2-ethylhexyl) phthalate; Clouding agents; Daily intake; Growth;

    机译:邻苯二甲酸二(2-乙基己基)酯;防云剂;每日摄入量;成长性;

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