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首页> 外文期刊>Environmental research >Physical activity, black carbon exposure and airway inflammation in an urban adolescent cohort
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Physical activity, black carbon exposure and airway inflammation in an urban adolescent cohort

机译：城市青少年队列中的体育活动，黑碳暴露和气道炎症

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摘要

Objective: Regular physical activity can improve cardiopulmonary health; however, increased respiratory rates and tidal volumes during activity may increase the effective internal dose of air pollution exposure. Our objective was to investigate the impact of black carbon (BC) measured by personal sampler on the relationship between physical activity and fractional exhaled nitric oxide (FeNO), a marker of airway inflammation. We hypothesized that higher personal BC would attenuate the protective effect of physical activity on airway inflammation. Methods: We performed a cross-sectional study nested in a birth cohort of African American and Dominican children living in the Bronx and Northern Manhattan, New York City. Children were recruited based on age (target 9-14 year olds) and presence (n=70) or absence (n=59) of current asthma. Children wore wrist mounted accelerometers for 6 days and were classified as 'active' if they had ＞ 60 min of moderate-to-vigorous activity (MVA) each day and 'non-active' if they had ＜ 60 min of MVA on any given day, based on CDC guidelines. Personal BC measured using a MicroAeth, was assessed during two 24-h periods, at the beginning and end of physical activity assessment High BC was defined as the upper tertile of BC measured with personal sampler. FeNO measurements were sampled at the beginning and end of the of physical activity assessment. Results: In multivariable linear regression models, 'active' children had 25% higher personal BC concentrations (p=0.02) and 20% lower FeNO (p=0.04) compared to 'non-active' childrea Among children with high personal BC (n=33), there was no relationship between activity and FeNO (p=1.00). The significant protective relationship between activity and airway inflammation was largely driven by children with lower personal BC (n=96, p=0.04). Conclusions: Children that live in an urban environment and are physically active on a daily basis have higher personal exposure to BC High BC offsets the protective relationship between physical activity and airway inflammation.
机译：目的：定期进行体育锻炼可以改善心肺健康；但是，在运动过程中增加呼吸频率和潮气量可能会增加暴露于空气中的有效内部剂量。我们的目标是研究个人采样器测量的黑碳（BC）对身体活动与呼出气一氧化氮（FeNO）（呼吸道炎症标记物）之间关系的影响。我们假设较高的个人BC会减弱体育锻炼对气道炎症的保护作用。方法：我们进行了一项横断面研究，该研究嵌套在居住在纽约市布朗克斯区和北曼哈顿区的非洲裔美国人和多米尼加裔儿童的出生队列中。根据年龄（目标年龄9-14岁）和当前哮喘的存在（n = 70）或不存在（n = 59）招募儿童。儿童佩戴手腕式加速度计达6天，如果每天的中度至剧烈运动（MVA）≥60分钟，则被定为“活跃”，如果给定的任何MVA ＜60分钟，则被定为“非活跃”根据CDC指南。在身体活动评估的开始和结束时的两个24小时内，评估了使用MicroAeth测量的个人BC，高BC被定义为使用个人采样器测量的BC的上三分位数。在身体活动评估的开始和结束时对FeNO测量值进行采样。结果：在多变量线性回归模型中，与“非活动”儿童相比，“活动”儿童的个人BC浓度高25％（p = 0.02），FeNO降低20％（p = 0.04）（n = 33），活性和FeNO之间没有关系（p = 1.00）。活动与气道炎症之间的重要保护关系很大程度上是由儿童个人BC较低引起的（n = 96，p = 0.04）。结论：生活在城市环境中且每天进行体育锻炼的儿童对BC的暴露量较高。BC偏高抵消了体育锻炼与气道炎症之间的保护关系。

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  • 来源
    《Environmental research》 |2016年第11期|756-762|共7页
  • 作者

    Stephanie. Lovinsky-Desir; Kyung Hwa Jung; Andrew G. Rundle; Lori A. Hoepner; Joshua B. Bautista; Frederica P. Perera; Steven N. Chillrud; Matthew S. Perzanowski; Rachel L. Miller;

  • 作者单位

    Division of Pediatric Pulmonology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 3959 Broadway CHC-745, New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168S., New York, NY 10032, United States;

    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168S., New York, NY 10032, United States;

    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168S., New York, NY 10032, United States,Department of Environmental and Occupational Health Sciences, State University of New York, Downstate School of Public Health, Box 43, 450 Clarkson Avenue, Brooklyn, NY 11203, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168S., New York, NY 10032, United States;

    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168S., New York, NY 10032, United States;

    Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, New York 10964, United States;

    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168S., New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168S., New York, NY 10032, United States,Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W. 168S., New York, NY 10032, United States,Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 St., New York, NY 10032, United States;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    FeNO; Exercise; Air pollution; Urban environment; Asthma;

    机译：FeNO;行使;空气污染;城市环境;哮喘;

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