...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental research >Variability and exposure classification of urinary phenol and paraben metabolite concentrations in reproductive-aged women
【24h】

Variability and exposure classification of urinary phenol and paraben metabolite concentrations in reproductive-aged women

机译：育龄妇女尿酚和对羟基苯甲酸酯代谢物浓度的变异性和暴露分类

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Human exposure to phenols and parabens is widespread. Within-person variability of urinary concentrations in healthy women is not well characterized. Objectives: To characterize the variability of urinary phenol and paraben concentrations across two months and evaluate the ability of a single spot urine sample to characterize exposure. Methods: 143 women provided 509 spot urine samples collected across two months of study (3-5 samples/woman). We measured urinary concentrations of 8 phenols: bisphenol A (BPA), benzophenone-3 (BP-3), benzophenone-1 (BP-1), 2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol (2,5-DCP), 2,4,5-trichlorophenol (2,4,5-TCP), 2,4,6-trichlorophenol (2,4,6-TCP), tridosan (TCS); and 8 parabens and their metabolites (benzyl (BzP), butyl (BuP), ethyl (EtP), heptyl (HeP), methyl (MeP), propyl (PrP), 4-hydro-xybenzoic acid (4-HB), 3,4-dihydroxybenzoic acid (3,4-DHB)). Biomarker variability was characterized using the intraclass correlation coefficient (ICC) and surrogate category analyses were conducted. Results: ICCs ranged from very low for BPA (0.04) to moderate for BP-3, BP-1, TCS, BzP, and MeP (0.66, 0.58, 0.55, 0.54, and 0.62, respectively). Surrogate analyses suggested that BP-1, BP-3, TCS, 2,4-DCP, BuP, and PrP may be characterized by a single spot sample (sensitivity range 0.76-0.86) but that additional samples were necessary for BPA, HeP, 4-HB, and 3,4-DHB (sensitivity range 0.47-0.61). Conclusions: Urinary phenol and paraben metabolite concentrations were variable across two months in healthy women but the degree of reliability differed by the specific biomarker. A small number of samples may sufficiently characterize typical concentrations for BP-3, BP-1, TCS, BuP, and PrP; but additional biospecimens may be necessary to characterize exposure for other compounds, including BPA.
机译：背景：人类广泛接触苯酚和对羟基苯甲酸酯。健康女性的人内尿液浓度的变异性尚不十分清楚。目的：表征两个月内尿酚和对羟基苯甲酸酯浓度的变异性，并评估单点尿液样品表征暴露的能力。方法：143名妇女提供了为期两个月的研究收集的509点尿液样本（每名妇女3-5个样本）。我们测量了8种酚的尿液浓度：双酚A（BPA），二苯甲酮3（BP-3），二苯甲酮-1（BP-1），2,4-二氯苯酚（2,4-DCP），2,5-二氯苯酚（2,5-DCP），2,4,5-三氯苯酚（2,4,5-TCP），2,4,6-三氯苯酚（2,4,6-TCP），三碘生（TCS）;和8种对羟基苯甲酸酯及其代谢物（苄基（BzP），丁基（BuP），乙基（EtP），庚基（HeP），甲基（MeP），丙基（PrP），4-氢-羟基苯甲酸（4-HB），3 ，4-二羟基苯甲酸（3,4-DHB））。使用类内相关系数（ICC）表征生物标志物的变异性，并进行替代类别分析。结果：ICC的范围从BPA的非常低（0.04）到BP-3，BP-1，TCS，BzP和MeP的中等（分别为0.66、0.58、0.55、0.54和0.62）。替代分析表明，BP-1，BP-3，TCS，2,4-DCP，BuP和PrP的特征可能是单点样品（灵敏度范围为0.76-0.86），但BPA，HeP， 4-HB和3,4-DHB（灵敏度范围0.47-0.61）。结论：健康女性的尿酚和对羟基苯甲酸酯代谢物浓度在两个月内变化，但可靠程度因特定的生物标志物而异。少量样品可能足以表征BP-3，BP-1，TCS，BuP和PrP的典型浓度。但是可能需要其他生物标本来表征包括BPA在内的其他化合物的暴露情况。

著录项

  • 来源
    《Environmental research》 |2016年第11期|513-520|共8页
  • 作者

    Anna Z. Pollack; Neil J. Perkins; Lindsey Sjaarda; Sunni L. Mumford; Kurunthachalam Kannan; Claire Philippat; Jean Wactawski-Wende; Enrique F. Schisterman;

  • 作者单位

    Department of Global and Community Health, College of Health and Human Services, George Mason University, 4400 University Drive, MS5B7, Fairfax, VA 22030, USA;

    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd., Rockville, MD 20852, USA;

    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd., Rockville, MD 20852, USA;

    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd., Rockville, MD 20852, USA;

    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA,Department of Environmental Health Sciences, University at Albany, School of Public Health, Empire State Plaza, P.O. Box 509, Albany, NY 12201 -0509, USA;

    Universite Grenoble Alpes, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, F-38000 Grenoble, France,INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, F-38000 Grenoble, France;

    Department of Epidemiology and Environmental Health, University at Buffalo. The State University of New York, 410 Kimball Hall, Buffalo, NY 14214, USA;

    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd., Rockville, MD 20852, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Benzophenone-3; Bisphenol A; Dichlorophenol; Intra-individual variability; Parabens; Reliability, Triclosan;

    机译：二苯甲酮3;双酚A;二氯苯酚个人内部变异性;对羟基苯甲酸酯;可靠性;三氯生;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号