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Prenatal mercury exposure and birth outcomes

机译：产前汞暴露和出生结局

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摘要

Background: Results regarding the association between mercury exposure and anthropometry at birth, gestational length and placental weight are inconsistent, as is the role of seafood intake in these associations. Objective: We assessed whether prenatal mercury exposure is associated with anthropometry at birth, placental weight and gestational length in a population with a relatively high exposure to mercury from seafood consumption. Methods: Total mercury (T-Hg) was determined in cord blood from 1869 newborns with birth outcome measures, within the Spanish multicenter INMA cohort from 2004 to 2008. We adjusted cohort specific linear and Cox regression models to evaluate the association between T-Hg and birth anthropometry (weight, length, and head circumference), placental weight and gestational length. Non-spontaneous labor was taken to be censoring in the survival analysis. Final estimates were obtained using meta-analysis. Results: Geometric mean T-Hg was 8.2 μg/L. A doubling of T-Hg was associated with a 7.7 g decrease in placental weight (95% CI: -13.6, -1.8) and marginally with head circumference (beta: -0.052 cm, 95% CI: -0.109, 0.005). T-Hg was also inversely related to weight and length, although with weaker estimates. Mercury exposure was not associated with the length of gestation. The inverse relation between T-Hg and growth was enhanced when the intake of different seafood groups was adjusted for in the models. Conclusions: Prenatal mercury exposure may be associated with reduced placental and fetal growth. Confounding by fish intake should be considered when assessing these relationships.
机译：背景：关于汞暴露与出生时人体测量学，妊娠期长度和胎盘重量之间关联的结果不一致，海鲜摄入量在这些关联中的作用也不一致。目的：我们评估了在海鲜消费中汞暴露量相对较高的人群中，产前汞暴露量与出生时的人体测量学，胎盘重量和妊娠长度是否相关。方法：在2004年至2008年西班牙多中心INMA队列中，对1869名新生儿的脐血中总汞（T-Hg）进行了出生结局测定。我们调整了队列特异性线性和Cox回归模型以评估T-Hg之间的关联以及出生人体测量法（体重，长度和头围），胎盘重量和孕期。在生存分析中，将非自发劳动视为检查对象。使用荟萃分析获得最终估计。结果：几何平均T-Hg为8.2μg/ L。 T-Hg的增加会使胎盘重量减少7.7 g（95％CI：-13.6，-1.8），而头围略有减少（β：-0.052 cm，95％CI：-0.109，0.005）。 T-Hg也与体重和长度成反比，尽管估计较弱。汞暴露与妊娠时间无关。当模型中调整了不同海鲜组的摄入量时，T-Hg与生长之间的反比关系得到增强。结论：产前汞暴露可能与胎盘和胎儿的生长减少有关。在评估这些关系时，应考虑鱼类摄入的混淆。

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  • 来源
    《Environmental research》 |2016年第11期|11-20|共10页
  • 作者

    Mario Murcia; Ferran Ballester; Ashley Michel Enning; Carmen Iniguez; Damaskini Valvi; Mikel Basterrechea; Marisa Rebagliato; Jesus Vioque; Maite Maruri; Adonina Tardon; Isolina Riano-Galan; Martine Vrijheid; Sabrina Llop;

  • 作者单位

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain,Health and Biomedical Research in the Valencian Region (FISABIO), Av. Catalunya 21, 46020 Valencia, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain,Nursing Department, Universitat de Valencia, Valencia, Spain;

    ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,Universitat Pompeu Fabra, Barcelona, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain,Universitat Pompeu Fabra, Barcelona, Spain,Harvard T.H. Chan School of Public Health, Boston, USA;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Public Health Division of Gipuzkoa, San Sebastian, Spain,Health Research Institute (BIODONOSTIA), San Sebastian, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain,Medicine Department, Universitat Jaume Ⅰ, Castello de la Plana, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Universidad Miguel Hernandez, San Juan de Alicante, Spain;

    OSI Goierri-Alto Urola, Centro de Salud de Azkoitia, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,IUOPA-Universidad de Oviedo, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Pediatric Unit, Hospital San Agustin, Aviles, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,Universitat Pompeu Fabra, Barcelona, Spain;

    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain,Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume Ⅰ-Universitat de Valencia, Valencia, Spain;

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  • 正文语种 eng
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  • 关键词

    Maternal exposure; Mercury; Birth weight; Gestational age; Placentation; Diet, food, and nutrition;

    机译：孕产妇接触;汞;出生体重;孕龄;胎盘饮食;食物和营养;

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