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首页> 外文期刊>Environmental research >Virgin microplastics cause toxicity and modulate the impacts of phenanthrene on biomarker responses in African catfish (Clarias gariepinus)
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Virgin microplastics cause toxicity and modulate the impacts of phenanthrene on biomarker responses in African catfish (Clarias gariepinus)

机译：原始的微塑料会引起毒性并调节菲对非洲cat鱼（Clarias gariepinus）的生物标志物响应的影响

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摘要

Despite the ubiquity of microplastics (MPs) in aquatic environments and their proven ability to carry a wide variety of chemicals, very little is known about the impacts of virgin or contaminant-loaded MPs on organisms. The primary aim of this study was to investigate the impacts of virgin or phenanthrene (Phe)-loaded low-density polyethylene (LDPE) fragments on a suite of biomarker responses in juvenile African catfish (Clarias gariepinus). Virgin LDPE (50 or 500 μg/L) were preloaded with one of two nominal Phe concentrations (10 or 100 μg/L) and were exposed to the fish for 96 h. Our findings showed one or both Phe treatments significantly increased the degree of tissue change (DTC) in the liver while decreased the transcription levels of forkhead box L2 (foxl2) and tryptophan hydroxylase2 (tph2) in the brain of C. gariepinus. Exposure to either levels of virgin MPs increased the DTC in the liver and plasma albumin: globulin ratio while decreased the transcription levels of tph2. Moreover, MPs modulated (interacted with) the impact of Phe on the DTC in the gill, plasma concentrations of cholesterol, high-density li-poprotein (HDL), total protein (TP), albumin, and globulin, and the transcription levels of fushi tarazu-factor 1 (ftz-f1), gonadotropin-releasing hormone (GnRH), 11 β-hydroxysteroid dehydrogenase type 2 (11β-hsd2), and liver glycogen stores. Results of this study highlight the ability of virgin LDPE fragments to cause toxicity and to modulate the adverse impacts of Phe in C. gariepinus. Due to the wide distribution of MPs and other classes of contaminants in aquatic environments, further studies are urgently needed to elucidate the toxicity of virgin or contaminant-loaded MPs on organisms.
机译：尽管在水生环境中普遍存在微塑料（MPs），并且它们被证明具有承载多种化学物质的能力，但对于原生的或负载污染物的MPs对生物的影响知之甚少。这项研究的主要目的是调查原始的或菲（Phe）加载的低密度聚乙烯（LDPE）片段对非洲African鱼（Clarias gariepinus）的一系列生物标志物响应的影响。将原始LDPE（50或500μg/ L）预先加载两个标称Phe浓度（10或100μg/ L）中的一种，并暴露于鱼中96 h。我们的研究结果表明，一种或两种Phe治疗均显着增加了肝脏中组织改变（DTC）的程度，同时降低了C. gariepinus脑中叉头盒L2（foxl2）和色氨酸羟化酶2（tph2）的转录水平。暴露于任何水平的原始MPs都会增加肝脏和血浆白蛋白：球蛋白比的DTC，同时降低tph2的转录水平。此外，MP调节（与之相互作用）Phe对the中DTC的影响，胆固醇，高密度脂蛋白（HDL），总蛋白（TP），白蛋白和球蛋白的血浆浓度，以及Phe的转录水平。 fushi tarazu因子1（ftz-f1），促性腺激素释放激素（GnRH），11型β-羟基类固醇脱氢酶2（11β-hsd2）和肝糖原存储。这项研究的结果突出了原始LDPE片段引起毒性和调节Phe对gar.pinie的不利影响的能力。由于MPs和其他类别污染物在水生环境中的广泛分布，迫切需要进一步研究以阐明原始MP或负载污染物的MPs对生物的毒性。

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  • 来源
    《Environmental research》 |2016年第11期|58-70|共13页
  • 作者

    Ali Karami; Nicholas Romano; Tamara Galloway; Hazilawati Hamzah;

  • 作者单位

    Laboratory of Aquatic Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia;

    Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400 Selangor, Malaysia;

    Department of Biosciences, University of Exeter, College of Life and Environmental Sciences, Exeter, UK;

    Haematology & Clinical Biochemistry Laboratory, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Selangor, Malaysia;

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  • 正文语种 eng
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  • 关键词

    Microplastics; Polyethylene; Gene transcription; Blood biochemistry; Histopathology;

    机译：微塑料;聚乙烯基因转录;血液生化;组织病理学;

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