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首页> 外文期刊>Environmental research >Repeatedly high polycyclic aromatic hydrocarbon exposure and cock-roach sensitization among inner-city children
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Repeatedly high polycyclic aromatic hydrocarbon exposure and cock-roach sensitization among inner-city children

机译：内城区儿童反复多环芳烃暴露和蟑螂致敏

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摘要

Background: Exposures to traffic-related air pollutants including polycyclic aromatic hydrocarbons (PAH) have been associated with the development and exacerbation of asthma. However, there is limited evidence on whether these pollutants are associated with the development of cockroach sensitization, a strong risk factor for urban asthma. We hypothesized that repeatedly high PAH exposure during childhood would be associated with increased risk of new cockroach sensitization. Methods: As part of the research being conducted by the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study in New York, a spot urine sample was collected from children at age 5 years (2003-2008) and again at age 9-10 years (2008-2012; n = 248) and analyzed for 10 PAH metabolites. Repeatedly high PAH (High-High) exposure was defined as measures above median for age 5 PAH metabolites at both time points. Child blood samples at age 5 and 9 years were analyzed for total, anti-cockroach, mouse, dust mite, cat and dog IgE. Relative risks (RR) were estimated with multivariable modified Poisson regression. Results: Individual PAH metabolite levels, except for 1-naphthol (1-OH-NAP), increased by 10-60% from age 5 to age 9-10. The prevalence of cockroach sensitization increased from 17.6% (33/188) at age 5 to 33.0% (62/188) at 9 years (p=0.001). After controlling for potential covariates including cockroach sensitization at age 5 in regression analyses, positive associations were found between repeatedly high exposure (High-High) to 1-OH-NAP, 3-hydroxyphenanthrene (3-OH-PHEN), or 1-hydroxypyrene (1-OH-PYR) and cockroach sensitization at age 9 (p-values ＜ 0.05). Compared to Low-Low exposure, the relative risk (RR) [95% CI] with repeatedly high exposure was 1.83 [1.06-3.17] for 1-OH-NAP, 1.54 [1.06-2.23] for 3-OH-PHEN, and 1.59 [1.04-2.43] for 1-OH-PYR. Conclusions: Repeatedly high levels of urinary PAH metabolites during childhood may increase likelihood of sensitization to cockroach allergen in urban inner-city children at age 9 years.
机译：背景：接触与交通有关的空气污染物，包括多环芳烃（PAH），已与哮喘的发展和加剧有关。但是，关于这些污染物是否与蟑螂致敏性发展相关的证据有限，蟑螂致敏性是城市哮喘的重要危险因素。我们假设儿童时期反复暴露于多环芳烃会增加新的蟑螂致敏风险。方法：作为纽约哥伦比亚儿童环境卫生中心（CCCEH）出生队列研究进行的研究的一部分，从5岁（2003-2008年）和9- 10年（2008-2012; n = 248）并分析了10种PAH代谢物。反复的高PAH（高-高）暴露定义为在两个时间点均高于5岁PAH代谢产物的中位数。分析了5岁和9岁儿童的血液样本中的总，抗蟑螂，小鼠，尘螨，猫和狗的IgE。相对风险（RR）通过多变量修正Poisson回归进行估计。结果：除了1-萘酚（1-OH-NAP）外，个人PAH代谢物水平从5岁到9-10岁增加了10-60％。蟑螂致敏的发生率从5岁时的17.6％（33/188）增加到9岁时的33.0％（62/188）（p = 0.001）。在回归分析中控制潜在的协变量（包括5岁时的蟑螂致敏）后，发现反复对1-OH-NAP，3-羟基菲（3-OH-PHEN）或1-羟基py进行高暴露（高-高）之间存在正相关（1-OH-PYR）和9岁时蟑螂致敏（p值<0.05）。与低-低暴露相比，1-OH-NAP的相对危险度（RR）[95％CI]反复为1.83 [1.06-3.17]，3-OH-PHEN为1.54 [1.06-2.23]， 1-OH-PYR为1.59 [1.04-2.43]。结论：儿童时期尿中PAH代谢物反复高水平，可能会增加9岁城市市区儿童对蟑螂过敏原致敏的可能性。

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  • 来源
    《Environmental research》 |2015年第7期|649-656|共8页
  • 作者

    Kyung Hwa Jung; Stephanie Lovinsky-Desir; Matthew Perzanowski; Xinhua Liu; Christina Maher; Eric Gil; David Torrone; Andreas Sjodin; Zheng Li; Frederica P. Perera; Rachel L. Miller;

  • 作者单位

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States;

    Division of Pediatric Pulmonary, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 3959 Broadway, CHC 7-745, New York, NY 10032, United States;

    Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States;

    Mailman School of Public Health, Department of Biostatistics, Columbia University, 722 W. 168 Street, New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States;

    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Atlanta, GA, United States;

    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Atlanta, GA, United States;

    Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States;

    Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States,Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States,Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States;

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  • 正文语种 eng
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  • 关键词

    Polycyclic aromatic hydrocarbons; Urinary metabolites; Cockroach IgE; Childhood; Inner-city;

    机译：多环芳烃;尿代谢产物;蟑螂IgE;童年;市区;

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