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首页> 外文期刊>Environmental research >Derivation and validation of BOREAS, a risk score identifying candidates to develop cold-induced hypertension
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Derivation and validation of BOREAS, a risk score identifying candidates to develop cold-induced hypertension

机译：BOREAS的推导和验证，BOREAS是一项风险评分，可识别患上感冒性高血压的人

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摘要

Introduction: Blood pressure increases in cold periods, but its implications on prevalence of hypertension and on individual progression to hypertension remain unclear. Our aim was to develop a pre-screening test for identifying candidates to suffer hypertension only in cold months among non-hypertensive subjects. Methods: We included 95,277 subjects registered on a primary care database from Girona (Catalonia, Spain), with ≥ 3 blood pressure measures recorded between 2003 and 2009 and distributed in both cold (October-March) and warm (April-September) periods. We defined four blood pressure patterns depending on the presence of hypertension through these periods. A Cox model determined the risk to develop vascular events associated with blood pressure patterns. A logistic regression distinguished those nonhypertensive individuals who are more prone to suffer cold-induced hypertension. Validity was assessed on the basis of calibration (using Brier score) and discrimination (using the area under the receiver operating characteristics). Results: In cold months, the mean systolic blood pressure increased by 3.3 ± 0.1 mmHg and prevalence of hypertension increased by 8.2%. Cold-induced hypertension patients were at higher vascular events risk (Hazard ratio=1.44 [95% Confidence interval 1.15-1.81]), than nonhypertensive individuals. We identified age, diabetes, body mass index and prehypertension as the major contributing factors to cold-induced hypertension onset. Discussion: Hypertension follows a seasonal pattern in some individuals. We recommend screening for hypertension during the cold months, at least in those nonhypertensive individuals identified as cold-induced hypertensive by this assessment tool.
机译：简介：寒冷时期血压会升高，但其对高血压患病率和个人发展为高血压的影响尚不清楚。我们的目标是开发一种预筛查测试，以识别仅在非高血压受试者中寒冷月份内患有高血压的候选人。方法：我们纳入了在赫罗纳（西班牙加泰罗尼亚）的初级保健数据库中注册的95277名受试者，在2003年至2009年之间记录了≥3次血压测量值，并且分布在寒冷（十月至三月）和温暖（四月至九月）期间。根据这些时期高血压的存在，我们定义了四种血压模式。 Cox模型确定了发生与血压模式相关的血管事件的风险。 Logistic回归分析区分了那些更容易遭受感冒诱发的高血压的非高血压患者。根据校准（使用Brier评分）和区分度（使用接收器工作特性下的面积）评估有效性。结果：在寒冷的月份，平均收缩压增加3.3±0.1 mmHg，高血压患病率增加8.2％。与非高血压患者相比，感冒诱发的高血压患者发生血管事件的风险更高（危险比= 1.44 [95％置信区间1.15-1.81]）。我们将年龄，糖尿病，体重指数和高血压前期确定为冷诱发高血压发作的主要因素。讨论：某些人的高血压遵循季节性模式。我们建议至少在寒冷的月份进行高血压筛查，至少在通过该评估工具确定为寒冷诱发的高血压的非高血压人群中。

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  • 来源
    《Environmental research》 |2014年第7期|190-196|共7页
  • 作者

    A. Ponjoan; M.M. Garcia-Gil; R. Marti; M. Comas-Cufi; L. Alves-i-Cabratosa; J. Sala; J. Marrugat; R. Elosua; G. Coll de Tuero; M. Grau; R. Ramos;

  • 作者单位

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain,Girona Biomedical Research Institute (IDIBGI), Trueta University Hospital, Catalonia, Spain;

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain,Primary Care Services, Girona. Catalan Institute of Health (ICS), Catalonia, Spain,Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Spain;

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain,Girona Biomedical Research Institute (IDIBGI), Trueta University Hospital, Catalonia, Spain;

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain;

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain;

    Girona Biomedical Research Institute (IDIBGI), Trueta University Hospital, Catalonia, Spain,Primary Care Services, Girona. Catalan Institute of Health (ICS), Catalonia, Spain,Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Spain;

    Research on Inflammatory and Cardiovascular Disorders Program (RICAD), Lipids and Cardiovascular Epidemiology Research Group (ULEC) and Cardiovascular, Epidemiology and Genetics Research Group (EGEC), Municipal Institute for Medical Research (IMIM), Barcelona, Spain;

    Research on Inflammatory and Cardiovascular Disorders Program (RICAD), Lipids and Cardiovascular Epidemiology Research Group (ULEC) and Cardiovascular, Epidemiology and Genetics Research Group (EGEC), Municipal Institute for Medical Research (IMIM), Barcelona, Spain;

    Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Spain,Research Unit, Healthcare Institute (IAS), Salt, Girona, Spain;

    Research on Inflammatory and Cardiovascular Disorders Program (RICAD), Lipids and Cardiovascular Epidemiology Research Group (ULEC) and Cardiovascular, Epidemiology and Genetics Research Group (EGEC), Municipal Institute for Medical Research (IMIM), Barcelona, Spain;

    Research Unit, Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain,Girona Biomedical Research Institute (IDIBGI), Trueta University Hospital, Catalonia, Spain,Primary Care Services, Girona. Catalan Institute of Health (ICS), Catalonia, Spain,Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Spain,c/Maluquer Salvador, 11, 17003 Girona, Spain;

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  • 正文语种 eng
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  • 关键词

    Blood pressure; Season; Temperature; Winter; Vascular disease;

    机译：血压;季节;温度;冬季;血管疾病;

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