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A feasibility study of the association of exposure to biomass smoke with vascular function, inflammation, and cellular aging

机译：暴露于生物质烟雾与血管功能，炎症和细胞衰老相关性的可行性研究

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摘要

Background: Biomass smoke at higher concentrations is associated with respiratory symptoms and, after years of exposure, increased risk of respiratory disorders in adults, but its effects on cardiovascular diseases are not well characterized, particularly compared with other pollution sources like tobacco smoke or traffic. Methods: We conducted a cross-sectional study and enrolled 25 women living in rural Sichuan, China. We measured integrated 24-h personal exposure to fine particulate matter (PM_(2.5)) and black carbon, and measured PM_(2.5) and black carbon in their kitchens. We assessed participants' brachial and central blood pressure and arterial stiffness using pulse wave analysis, and analyzed dried blood spot and buccal cell samples for C-reactive protein and relative telomere length. We also evaluated the difference in these physiological and biomarker measures between individuals with high (≥ median) versus low ( ＜ median) PM_(2.5) exposure using multivariate regression. Results: Geometric mean 24-h PM_(2.5) and black carbon exposures were 61 μg/m~3 (95% CI: 48, 78) and 3.2 μg/m~3 (95% CI: 2.3, 4.5), respectively. Average kitchen PM_(2.5) and black carbon concentrations were only moderately correlated with personal exposures (PM_(2.5): r=0.41; black carbon: r=0.63), although they had similar means. Women in the high and low exposure groups were similar in age, obesity, socioeconomic status, salt intake, and physical activity. Women in the high PM_(2.5) exposure group had higher mean brachial systolic blood pressure (SBP; difference=4.6 mmHg, 95% CI -7.8,16.9), central SBP (difference=3.1 mmHg, 95% CI: -8.4,14.5), central pulse pressure (difference=4.1 mmHg; 95% CI: -4.2, 12.4), and augmentation index (difference=2.8%, 95% CI: -1.6, 7.2). High exposed women had 43% shorter telomere length (95% CI: -113, 28) than that of women in the low exposure group. There were no differences in pulse wave velocity or C-reactive protein between the two exposure groups. None of the results was statistically significant. Conclusions: Our results suggest that it is feasible to measure markers of vascular function and biomarkers of inflammation and oxidative stress in field studies of biomass smoke. Although many of the associations were in the expected direction, larger studies would be needed to establish the effects.
机译：背景：较高浓度的生物质烟与呼吸系统症状有关，经过多年的暴露，成人呼吸系统疾病的风险增加，但其对心血管疾病的影响尚不明确，尤其是与其他污染源（如烟草烟雾或交通）相比。方法：我们进行了一项横断面研究，招募了25位生活在中国四川农村的妇女。我们测量了24小时个人对细颗粒物（PM_（2.5））和黑碳的总暴露量，并测量了他们厨房中的PM_（2.5）和黑碳。我们使用脉搏波分析评估了参与者的肱和中央血压以及动脉僵硬度，并分析了干血斑和颊细胞样品中的C反应蛋白和相对端粒长度。我们还使用多元回归评估了PM_（2.5）暴露水平高（≥中位数）和低（＜中位数）的个体之间在这些生理和生物标志物测量方法上的差异。结果：24小时PM_（2.5）和黑碳暴露的几何平均数分别为61μg/ m〜3（95％CI：48，78）和3.2μg/ m〜3（95％CI：2.3，4.5）。尽管厨房平均PM_（2.5）和黑碳浓度与个人暴露呈中等程度的相关性（PM_（2.5）：r = 0.41；黑碳：r = 0.63），尽管它们具有相似的平均值。高和低暴露组的妇女在年龄，肥胖，社会经济状况，食盐摄入和体育锻炼方面相似。高PM_（2.5）暴露组的女性平均肱动脉收缩压（SBP;差异= 4.6 mmHg，95％CI -7.8,16.9），中枢性SBP（差异= 3.1 mmHg，95％CI：-8.4,14.5 ），中心脉压（差= 4.1 mmHg; 95％CI：-4.2，12.4）和增强指数（差= 2.8％，95％CI：-1.6，7.2）。高暴露人群的女性端粒长度比低暴露人群的女性短43％（95％CI：-113，28）。两个暴露组之间的脉搏波速度或C反应蛋白无差异。所有结果均无统计学意义。结论：我们的结果表明，在生物质烟的现场研究中，测量血管功能标记以及炎症和氧化应激的生物标记是可行的。尽管许多协会都朝着预期的方向发展，但仍需要进行更大的研究才能确定效果。

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  • 来源
    《Environmental research》 |2014年第11期|165-172|共8页
  • 作者

    Ming Shan; Xudong Yang; Majid Ezzati; Nishi Chaturvedi; Emma Coady; Alun Hughes; Yuhui Shi; Ming Yang; Yuanxun Zhang; Jill Baumgartner;

  • 作者单位

    Department of Building Science, Tsinghua University, Beijing Haidian District, Beijing 100084, China;

    Department of Building Science, Tsinghua University, Beijing Haidian District, Beijing 100084, China;

    MRC-PHE Center for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, UK;

    International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College London, London, UK,Institute of Cardiovascular Science, University College London, London, UK;

    International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College London, London, UK,Institute of Cardiovascular Science, University College London, London, UK;

    International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College London, London, UK,Institute of Cardiovascular Science, University College London, London, UK;

    Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China;

    College of Life Science and Technology, Beijing University of Chemical Technology, Beijing China;

    College of Resources and Environment, University of the Chinese Academy of Sciences, Beijing, China;

    Institute on the Environment, University of Minnesota, St. Paul, MN, USA,Institute for Health and Social Policy and Department of Epidemiology, Biostatistics & Occupational Health, McGill University, 1130 des Pins Avenue Ouest, Montreal, QC, Canada H3A 1A3;

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  • 正文语种 eng
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  • 关键词

    Arterial stiffness; Blood pressure; Household air pollution; Inflammation; Solid fuels; Telomere length;

    机译：动脉僵硬;血压;家庭空气污染;炎;固体燃料;端粒长度;

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