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首页> 外文期刊>Environmental research >Association between methylmercury and cardiovascular risk factors in a native population of Quebec (Canada): A retrospective evaluation
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Association between methylmercury and cardiovascular risk factors in a native population of Quebec (Canada): A retrospective evaluation

机译：魁北克（加拿大）本地居民甲基汞与心血管危险因素之间的关联：回顾性评估

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摘要

Background: Epidemiological evidence suggests a negative impact of methylmercury (MeHg) on cardiovascular risk factors such as blood pressure (BP) and heart rate (HR). This issue is of concern in Arctic populations such as in the Inuit of Nunavik since this contaminant is accumulated in fish and marine mammals, which still represent the subsistence diet of this population. Objective: We examined the associations between MeHg and BP and resting HR among Inuit adults. Methods: The "Sante Quebec" health survey was conducted in 1992 in the 14 villages of Nunavik and a complete set of data was obtained for 313 Inuit adults ≥ 18 years. Blood samples were collected in order to determine total mercury, lead, total polychlorinated biphenyls (PCBs), n-3 polyunsaturated fatty acids (PUFAs), fasting glucose and lipid profile while socio-demographic variables were obtained through questionnaires. Anthropometric measurements as well as BP and resting HR were obtained using standardised protocols. Pulse pressure (PP: systolic BP minus diastolic BP) was also calculated. Multiple linear regression was used in order to determine the change in the dependent variables associated with the quartiles of MeHg concentration, taking the quartile 1 as reference. Results: The mean age of the participants was 38 ± 14 years and the sample was composed of 132 men (42.2%) and 181 women (57.8%). MeHg geometric mean was 15.4 ug/L (95%CI: 13.9-17.0) and levels ranged from 0.8 to 112.0 ug/L Resting HR increased linearly across quartiles of blood MeHg concentration after adjusting for confounders (p for trend=0.02). An increase of 6.9 beats per minute (bpm) between the 4th and 1st quartile was observed after adjusting for confounders. No significant association was observed between blood MeHg and systolic BP, diastolic BP or PP. Conclusions: MeHg was associated with increasing resting HR after considering traditional risk factors as well as other contaminants (lead and total PCBs) and n-3 PUFAs. In contrast, no significant association with blood pressure was observed in this study.
机译：背景：流行病学证据表明甲基汞（MeHg）对心血管危险因素如血压（BP）和心率（HR）具有负面影响。这个问题在诸如努纳维克因纽特人的北极人口中是令人关注的，因为这种污染物积累在鱼类和海洋哺乳动物中，它们仍然代表着该种群的生存饮食。目的：我们研究了因纽特人成年人的MeHg和BP与静息HR的关系。方法：1992年在努纳维克（Nunavik）的14个村庄进行了“魁北克桑特”健康调查，并获得了313名18岁以上因纽特人的完整数据。收集血液样本以确定总汞，铅，总多氯联苯（PCB），n-3多不饱和脂肪酸（PUFA），空腹血糖和脂质分布，同时通过问卷调查获得社会人口统计学变量。人体测量以及血压和静息HR使用标准化协议获得。还计算脉压（PP：收缩压减去舒张压）。为了确定与MeHg浓度四分位数相关的因变量的变化，使用了多元线性回归，以四分位数1为参考。结果：参与者的平均年龄为38±14岁，样本由132名男性（42.2％）和181名女性（57.8％）组成。 MeHg几何平均值为15.4 ug / L（95％CI：13.9-17.0），水平范围为0.8至112.0 ug / L（调整混杂因素后，静息HR在四分位数的血液MeHg浓度中呈线性增加（趋势p值为0.02）。调整混杂因素后，在第4个四分位数与第1个四分位数之间观察到每分钟（bpm）6.9拍的增加。血液中的MeHg与收缩压，舒张压BP或PP之间无显着关联。结论：在考虑了传统的危险因素以及其他污染物（铅和总PCB）和n-3 PUFA之后，MeHg与静息心率增加有关。相反，在这项研究中未观察到与血压的显着关联。

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  • 来源
    《Environmental research》 |2013年第1期|102-108|共7页
  • 作者

    Beatriz Valera; Eric Dewailly; Paul Poirier;

  • 作者单位

    Axe sante des populations et environnementale, Centre de recherche du CHUQ, Edifice Delta 2, 2875, boulevard Laurier, 6e etage, Sainte-Foy, Quebec, Canada G1V 2M2;

    Axe sante des populations et environnementale, Centre de recherche du CHUQ, Edifice Delta 2, 2875, boulevard Laurier, 6e etage, Sainte-Foy, Quebec, Canada G1V 2M2,Department of Social and Preventive Medicine, Laval University, Quebec, Canada;

    Quebec Heart and Lung Institute, Quebec, Canada,Faculty of pharmacy, Laval University, Quebec, Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    methylmercury; N-3 polyunsaturated fatty acids (PUFAs); blood pressure; heart rate; inuit; nunavik;

    机译：甲基汞N-3多不饱和脂肪酸（PUFA）;血压;心率;因纽特人努纳维克;

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