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首页> 外文期刊>Environmental research >Prenatal exposures to environmental chemicals and birth order as risk factors for child behavior problems
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Prenatal exposures to environmental chemicals and birth order as risk factors for child behavior problems

机译：产前暴露于环境化学物质和出生顺序是儿童行为问题的危险因素

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摘要

Objectives: To assess whether polychlorinated biphenyls (PCBs), methylmercury, lead, or parental child-rearing attitudes was most crucial for maladaptive behavior problems, we examined Japanese 30-month-old children followed up from pregnancy. Methods: The Child Behavior Checklist (CBCL) was used to assess the behavior problems in 306 children. The associations of cord-blood total PCBs (ΣPCB), total mercury (THg), and lead with each CBCL subscale were examined by multivariate analyses. Results: The median values in cord blood of the 306 children were 48.3 (5 and 95 percentiles, 18.6-116.3) ng/g-lipid for ΣPCB, 10.2 (4.1-24.5) ng/g for THg, and 1.0 (0.5-1.7) μg/dl for lead. The internalizing score of the CBCL was significantly correlated with ΣPCB (r=0.113) in the children, though no significant correlation was seen between any CBCL score and either THg or lead. The significant correlation disappeared when conducting multiple regression analysis with possible confounders; at that time, the birth order, home environment, and maternal intelligence quotient were significantly related to the internalizing score. Three CBCL scores and ΣPCB levels were significantly higher in the first-born children than in the second-born or following children, and the partial correlation coefficient with the adjustment for all confounders except birth order was significant between the internalizing score and ΣPCB in the latter children (r=0.175). Conclusions: Internalizing behavior appears to be affected by prenatal exposure to PCBs at low levels. Under lower-level exposures, however, behavior problems may be more strongly associated with parental child-rearing attitudes involved in birth order, than with such hazardous chemicals.
机译：目的：为了评估多氯联苯（PCBs），甲基汞，铅或父母育儿的态度对于适应不良行为问题是否最关键，我们研究了日本30个月大的孕妇。方法：使用儿童行为清单（CBCL）评估306名儿童的行为问题。通过多变量分析检查了脐血总PCB（ΣPCB），总汞（THg）和铅与每个CBCL子量表的关联。结果：306名儿童的脐带血中位数，ΣPCB为48.3（5％和95％，18.6-116.3）ng / g-脂质，THg为10.2（4.1-24.5）ng / g，1.0（0.5-1.7） ）铅的微克/分升尽管儿童的CBCL评分与THg或铅之间无显着相关性，但儿童的CBCL的内部化评分与ΣPCB显着相关（r = 0.113）。与可能的混杂因素进行多元回归分析时，显着相关性消失了。当时，出生顺序，家庭环境和母亲的智商与内部化得分显着相关。第一胎婴儿的三个CBCL得分和ΣPCB水平显着高于第二胎或随后的孩子，除出生顺序外，所有混杂因素调整后的偏相关系数在后者的内化得分和ΣPCB之间均显着儿童（r = 0.175）。结论：内在行为似乎受到产前低水平PCB暴露的影响。但是，在较低水平的接触下，与此类有害化学物质相比，行为问题可能与参与生育顺序的父母育儿态度更相关。

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  • 来源
    《Environmental research》 |2012年第4期|p.47-52|共6页
  • 作者

    Nozomi Tatsuta; Kunihiko Nakai; Katsuyuki Murata; Keita Suzuki; Miyuki Iwai-Shimada; Kozue Yaginuma-Sakurai; Naoyuki Kurokawa; Tomoyuki Nakamura; Toru Hosokawa; Hiroshi Satoh;

  • 作者单位

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Akita University Graduate School of Medicine, Akita 010-8543, Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

    Human Development and Disabilities, Tohoku University Graduate School of Education, Sendai 980-8576, Japan;

    Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575. Japan;

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  • 正文语种 eng
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  • 关键词

    child behavior problems; birth order; polychlorinated biphenyls; methylmercury; lead;

    机译：儿童行为问题;出生顺序;多氯联苯;甲基汞铅;

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